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Showing metabocard for 4-Hydroxy-L-glutamic acid (HMDB0002273)

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enzymes (4) Show 4 proteins
Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2006-05-22 14:17:45 UTC
Update Date2022-09-22 18:34:16 UTC
HMDB IDHMDB0002273
Secondary Accession Numbers
  • HMDB0001344
  • HMDB01344
  • HMDB02273
Metabolite Identification
Common Name4-Hydroxy-L-glutamic acid
Description4-Hydroxy-L-glutamic acid, also known as erythro-4-hydroxy-L-glutamate or 2-hydroxy-4-aminoglutarate, belongs to the class of organic compounds known as glutamic acid and derivatives. Glutamic acid and derivatives are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. In humans, 4-hydroxy-L-glutamic acid is involved in the metabolic disorder called the arginine: glycine amidinotransferase deficiency (agat deficiency) pathway. 4-Hydroxy-L-glutamic acid is a primary metabolite. Primary metabolites are metabolically or physiologically essential metabolites. They are directly involved in an organism’s growth, development or reproduction. Based on a literature review a significant number of articles have been published on 4-Hydroxy-L-glutamic acid.
Structure
Data?1582752240
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0002273 (4-Hydroxy-L-glutamic acid)


  Mrv1652303062020152D          

 11 10  0  0  0  0            999 V2000
 9999.2842 9999.7990    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9999.998910000.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.7136 9999.7990    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10001.431410000.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.1451 9999.7990    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.431410001.0362    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.7136 9998.9737    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.569510000.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.8548 9999.7990    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.569510001.0362    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9999.2842 9998.9737    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  8  1  0  0  0  0
  1 11  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  7  1  6  0  0  0
  4  5  1  0  0  0  0
  4  6  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
M  END
Download

3D MOL for HMDB0002273 (4-Hydroxy-L-glutamic acid)

HMDB0002273
     RDKit          3D
4-Hydroxy-L-glutamic acid
 20 19  0  0  0  0  0  0  0  0999 V2000
    0.5178   -0.0143    1.2167 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8688   -0.4024   -0.1299 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0628    0.3308   -1.0772 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4939   -0.0568   -0.7702 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7127   -1.4115   -0.9154 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8742    0.3906    0.5710 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.6065    0.8570 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3794   -0.5195    1.4969 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.0102   -0.3971 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7805   -0.2589   -1.5214 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0338    0.6220    0.5604 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8834    0.9620    1.4150 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9494   -0.7180    1.8562 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7298   -1.4793   -0.2158 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2118    0.0773   -2.1138 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0388    1.4300   -0.9698 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1348    0.4713   -1.5096 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9559   -1.8678   -1.3546 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3788   -0.6966    1.5023 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4388    1.5448    0.4626 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  6  7  2  0
  6  8  1  0
  2  9  1  0
  9 10  2  0
  9 11  1  0
  1 12  1  0
  1 13  1  0
  2 14  1  1
  3 15  1  0
  3 16  1  0
  4 17  1  6
  5 18  1  0
  8 19  1  0
 11 20  1  0
M  END
Download

3D SDF for HMDB0002273 (4-Hydroxy-L-glutamic acid)


  Mrv1652303062020152D          

 11 10  0  0  0  0            999 V2000
 9999.2842 9999.7990    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9999.998910000.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.7136 9999.7990    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10001.431410000.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.1451 9999.7990    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.431410001.0362    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.7136 9998.9737    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.569510000.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.8548 9999.7990    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9998.569510001.0362    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9999.2842 9998.9737    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  8  1  0  0  0  0
  1 11  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  7  1  6  0  0  0
  4  5  1  0  0  0  0
  4  6  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0002273

> <DATABASE_NAME>
hmdb

> <SMILES>
N[C@@H](C[C@@H](O)C(O)=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1

> <INCHI_KEY>
HBDWQSHEVMSFGY-STHAYSLISA-N

> <FORMULA>
C5H9NO5

> <MOLECULAR_WEIGHT>
163.1287

> <EXACT_MASS>
163.048072403

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
20

> <JCHEM_AVERAGE_POLARIZABILITY>
14.014612264842874

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S,4R)-2-amino-4-hydroxypentanedioic acid

> <ALOGPS_LOGP>
-3.67

> <JCHEM_LOGP>
-4.246000214409296

> <ALOGPS_LOGS>
-0.34

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
3.611738188377349

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.6839758422188136

> <JCHEM_PKA_STRONGEST_BASIC>
9.160931011999752

> <JCHEM_POLAR_SURFACE_AREA>
120.85000000000001

> <JCHEM_REFRACTIVITY>
32.7363

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
7.43e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2S,4R)-2-amino-4-hydroxypentanedioic acid

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0002273 (4-Hydroxy-L-glutamic acid)

HMDB0002273
     RDKit          3D
4-Hydroxy-L-glutamic acid
 20 19  0  0  0  0  0  0  0  0999 V2000
    0.5178   -0.0143    1.2167 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8688   -0.4024   -0.1299 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0628    0.3308   -1.0772 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4939   -0.0568   -0.7702 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7127   -1.4115   -0.9154 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8742    0.3906    0.5710 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.6065    0.8570 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3794   -0.5195    1.4969 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.0102   -0.3971 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7805   -0.2589   -1.5214 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0338    0.6220    0.5604 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8834    0.9620    1.4150 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9494   -0.7180    1.8562 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7298   -1.4793   -0.2158 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2118    0.0773   -2.1138 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0388    1.4300   -0.9698 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1348    0.4713   -1.5096 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9559   -1.8678   -1.3546 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3788   -0.6966    1.5023 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4388    1.5448    0.4626 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  6  7  2  0
  6  8  1  0
  2  9  1  0
  9 10  2  0
  9 11  1  0
  1 12  1  0
  1 13  1  0
  2 14  1  1
  3 15  1  0
  3 16  1  0
  4 17  1  6
  5 18  1  0
  8 19  1  0
 11 20  1  0
M  END
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PDB for HMDB0002273 (4-Hydroxy-L-glutamic acid)

HEADER    PROTEIN                                 06-MAR-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   06-MAR-20         0                                  
HETATM    1  C   UNK     0    8665.3318666.291   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8666.6658667.061   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8667.9998666.291   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0    8669.3398667.061   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0    8670.6718666.291   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0    8669.3398668.601   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0    8667.9998664.751   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0    8663.9968667.061   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0    8662.6628666.291   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0    8663.9968668.601   0.000  0.00  0.00           O+0
HETATM   11  N   UNK     0    8665.3318664.751   0.000  0.00  0.00           N+0
CONECT    1    2    8   11                                                  
CONECT    2    1    3                                                       
CONECT    3    2    4    7                                                  
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4                                                            
CONECT    7    3                                                            
CONECT    8    1    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8                                                            
CONECT   11    1                                                            
MASTER        0    0    0    0    0    0    0    0   11    0   20    0
END
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3D PDB for HMDB0002273 (4-Hydroxy-L-glutamic acid)

COMPND    HMDB0002273
HETATM    1  N1  UNL     1       0.518  -0.014   1.217  1.00  0.00           N  
HETATM    2  C1  UNL     1       0.869  -0.402  -0.130  1.00  0.00           C  
HETATM    3  C2  UNL     1      -0.063   0.331  -1.077  1.00  0.00           C  
HETATM    4  C3  UNL     1      -1.494  -0.057  -0.770  1.00  0.00           C  
HETATM    5  O1  UNL     1      -1.713  -1.412  -0.915  1.00  0.00           O  
HETATM    6  C4  UNL     1      -1.874   0.391   0.571  1.00  0.00           C  
HETATM    7  O2  UNL     1      -1.732   1.606   0.857  1.00  0.00           O  
HETATM    8  O3  UNL     1      -2.379  -0.520   1.497  1.00  0.00           O  
HETATM    9  C5  UNL     1       2.272  -0.010  -0.397  1.00  0.00           C  
HETATM   10  O4  UNL     1       2.780  -0.259  -1.521  1.00  0.00           O  
HETATM   11  O5  UNL     1       3.034   0.622   0.560  1.00  0.00           O  
HETATM   12  H1  UNL     1       0.883   0.962   1.415  1.00  0.00           H  
HETATM   13  H2  UNL     1       0.949  -0.718   1.856  1.00  0.00           H  
HETATM   14  H3  UNL     1       0.730  -1.479  -0.216  1.00  0.00           H  
HETATM   15  H4  UNL     1       0.212   0.077  -2.114  1.00  0.00           H  
HETATM   16  H5  UNL     1       0.039   1.430  -0.970  1.00  0.00           H  
HETATM   17  H6  UNL     1      -2.135   0.471  -1.510  1.00  0.00           H  
HETATM   18  H7  UNL     1      -0.956  -1.868  -1.355  1.00  0.00           H  
HETATM   19  H8  UNL     1      -3.379  -0.697   1.502  1.00  0.00           H  
HETATM   20  H9  UNL     1       3.439   1.545   0.463  1.00  0.00           H  
CONECT    1    2   12   13
CONECT    2    3    9   14
CONECT    3    4   15   16
CONECT    4    5    6   17
CONECT    5   18
CONECT    6    7    7    8
CONECT    8   19
CONECT    9   10   10   11
CONECT   11   20
END
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SMILES for HMDB0002273 (4-Hydroxy-L-glutamic acid)

N[C@@H](C[C@@H](O)C(O)=O)C(O)=O
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INCHI for HMDB0002273 (4-Hydroxy-L-glutamic acid)

InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
(2S,4R)-2-Amino-4-hydroxypentanedioic acidChEBI
L-Erythro-4-hydroxyglutamic acidChEBI
Erythro-4-hydroxy-L-glutamateKegg
(2S,4R)-2-Amino-4-hydroxypentanedioateGenerator
L-Erythro-4-hydroxyglutamateGenerator
Erythro-4-hydroxy-L-glutamic acidGenerator
4-Hydroxy-L-glutamateGenerator
(4R)-4-Hydroxy-L-glutamateHMDB
(4R)-4-Hydroxy-L-glutamic acidHMDB
2-Hydroxy-4-aminoglutarateHMDB
2-Hydroxy-4-aminoglutaric acidHMDB
4-HydroxyglutamateHMDB
4-Hydroxyglutamic acidHMDB
(2S)-2-Amino-4-hydroxypentanedioic acidHMDB
gamma-Hydroxyglutamic acidHMDB
Γ-hydroxyglutamic acidHMDB
4-Hydroxy-L-glutamic acidHMDB
Chemical FormulaC5H9NO5
Average Molecular Weight163.1287
Monoisotopic Molecular Weight163.048072403
IUPAC Name(2S,4R)-2-amino-4-hydroxypentanedioic acid
Traditional Name(2S,4R)-2-amino-4-hydroxypentanedioic acid
CAS Registry Number2485-33-8
SMILES
N[C@@H](C[C@@H](O)C(O)=O)C(O)=O
InChI Identifier
InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
InChI KeyHBDWQSHEVMSFGY-STHAYSLISA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as glutamic acid and derivatives. Glutamic acid and derivatives are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentGlutamic acid and derivatives
Alternative Parents
Substituents
  • Glutamic acid or derivatives
  • Alpha-amino acid
  • L-alpha-amino acid
  • Amino fatty acid
  • Short-chain hydroxy acid
  • Hydroxy fatty acid
  • Alpha-hydroxy acid
  • Fatty acyl
  • Fatty acid
  • Dicarboxylic acid or derivatives
  • Hydroxy acid
  • 1,3-aminoalcohol
  • Amino acid
  • Secondary alcohol
  • Carboxylic acid
  • Organic nitrogen compound
  • Primary aliphatic amine
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Hydrocarbon derivative
  • Carbonyl group
  • Organic oxide
  • Amine
  • Organopnictogen compound
  • Organic oxygen compound
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Not AvailableNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility565 g/LALOGPS
logP-3.7ALOGPS
logP-4.2ChemAxon
logS-0.34ALOGPS
pKa (Strongest Acidic)1.68ChemAxon
pKa (Strongest Basic)9.16ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area120.85 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity32.74 m³·mol⁻¹ChemAxon
Polarizability14.01 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+132.37330932474
DeepCCS[M-H]-129.97730932474
DeepCCS[M-2H]-165.06330932474
DeepCCS[M+Na]+139.79430932474
AllCCS[M+H]+136.632859911
AllCCS[M+H-H2O]+132.732859911
AllCCS[M+NH4]+140.332859911
AllCCS[M+Na]+141.332859911
AllCCS[M-H]-126.932859911
AllCCS[M+Na-2H]-128.632859911
AllCCS[M+HCOO]-130.532859911

Predicted Retention Times

Underivatized

Chromatographic MethodRetention TimeReference
Measured using a Waters Acquity ultraperformance liquid chromatography (UPLC) ethylene-bridged hybrid (BEH) C18 column (100 mm × 2.1 mm; 1.7 μmparticle diameter). Predicted by Afia on May 17, 2022. Predicted by Afia on May 17, 2022.0.97 minutes32390414
Predicted by Siyang on May 30, 20229.7968 minutes33406817
Predicted by Siyang using ReTip algorithm on June 8, 20228.17 minutes32390414
AjsUoB = Accucore 150 Amide HILIC with 10mM Ammonium Formate, 0.1% Formic Acid441.8 seconds40023050
Fem_Long = Waters ACQUITY UPLC HSS T3 C18 with Water:MeOH and 0.1% Formic Acid482.6 seconds40023050
Fem_Lipids = Ascentis Express C18 with (60:40 water:ACN):(90:10 IPA:ACN) and 10mM NH4COOH + 0.1% Formic Acid347.4 seconds40023050
Life_Old = Waters ACQUITY UPLC BEH C18 with Water:(20:80 acetone:ACN) and 0.1% Formic Acid26.1 seconds40023050
Life_New = RP Waters ACQUITY UPLC HSS T3 C18 with Water:(30:70 MeOH:ACN) and 0.1% Formic Acid214.2 seconds40023050
RIKEN = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid107.5 seconds40023050
Eawag_XBridgeC18 = XBridge C18 3.5u 2.1x50 mm with Water:MeOH and 0.1% Formic Acid309.9 seconds40023050
BfG_NTS_RP1 =Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) with Water:ACN and 0.1% Formic Acid216.5 seconds40023050
HILIC_BDD_2 = Merck SeQuant ZIC-HILIC with ACN(0.1% formic acid):water(16 mM ammonium formate)920.3 seconds40023050
UniToyama_Atlantis = RP Waters Atlantis T3 (2.1 x 150 mm, 5 um) with ACN:Water and 0.1% Formic Acid602.0 seconds40023050
BDD_C18 = Hypersil Gold 1.9µm C18 with Water:ACN and 0.1% Formic Acid44.2 seconds40023050
UFZ_Phenomenex = Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex with Water:MeOH and 0.1% Formic Acid726.1 seconds40023050
SNU_RIKEN_POS = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid222.7 seconds40023050
RPMMFDA = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid346.1 seconds40023050
MTBLS87 = Merck SeQuant ZIC-pHILIC column with ACN:Water and :ammonium carbonate758.9 seconds40023050
KI_GIAR_zic_HILIC_pH2_7 = Merck SeQuant ZIC-HILIC with ACN:Water and 0.1% FA536.5 seconds40023050
Meister zic-pHILIC pH9.3 = Merck SeQuant ZIC-pHILIC column with ACN:Water 5mM NH4Ac pH9.3 and 5mM ammonium acetate in water497.6 seconds40023050

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
4-Hydroxy-L-glutamic acidN[C@@H](C[C@@H](O)C(O)=O)C(O)=O2373.0Standard polar33892256
4-Hydroxy-L-glutamic acidN[C@@H](C[C@@H](O)C(O)=O)C(O)=O1300.3Standard non polar33892256
4-Hydroxy-L-glutamic acidN[C@@H](C[C@@H](O)C(O)=O)C(O)=O1798.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
4-Hydroxy-L-glutamic acid,1TMS,isomer #1C[Si](C)(C)O[C@H](C[C@H](N)C(=O)O)C(=O)O1617.9Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,1TMS,isomer #2C[Si](C)(C)OC(=O)[C@H](O)C[C@H](N)C(=O)O1582.5Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,1TMS,isomer #3C[Si](C)(C)OC(=O)[C@@H](N)C[C@@H](O)C(=O)O1585.4Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,1TMS,isomer #4C[Si](C)(C)N[C@@H](C[C@@H](O)C(=O)O)C(=O)O1625.6Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H](N)C[C@@H](O[Si](C)(C)C)C(=O)O1644.1Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TMS,isomer #2C[Si](C)(C)OC(=O)[C@@H](C[C@H](N)C(=O)O)O[Si](C)(C)C1632.1Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TMS,isomer #3C[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C)C(=O)O)C(=O)O1700.3Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TMS,isomer #4C[Si](C)(C)OC(=O)[C@@H](N)C[C@@H](O)C(=O)O[Si](C)(C)C1588.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TMS,isomer #5C[Si](C)(C)N[C@@H](C[C@@H](O)C(=O)O[Si](C)(C)C)C(=O)O1679.4Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TMS,isomer #6C[Si](C)(C)N[C@@H](C[C@@H](O)C(=O)O)C(=O)O[Si](C)(C)C1674.7Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TMS,isomer #7C[Si](C)(C)N([C@@H](C[C@@H](O)C(=O)O)C(=O)O)[Si](C)(C)C1843.7Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H](N)C[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C1662.5Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TMS,isomer #2C[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C)C(=O)O)C(=O)O[Si](C)(C)C1732.6Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TMS,isomer #3C[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O1737.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TMS,isomer #4C[Si](C)(C)O[C@H](C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O1847.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TMS,isomer #5C[Si](C)(C)N[C@@H](C[C@@H](O)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C1708.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TMS,isomer #6C[Si](C)(C)OC(=O)[C@H](O)C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C1832.5Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TMS,isomer #7C[Si](C)(C)OC(=O)[C@H](C[C@@H](O)C(=O)O)N([Si](C)(C)C)[Si](C)(C)C1855.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #1C[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C1777.1Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #1C[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C1803.1Standard non polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #1C[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C1869.1Standard polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #2C[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C)C(=O)O)N([Si](C)(C)C)[Si](C)(C)C1878.7Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #2C[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C)C(=O)O)N([Si](C)(C)C)[Si](C)(C)C1882.6Standard non polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #2C[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C)C(=O)O)N([Si](C)(C)C)[Si](C)(C)C1993.3Standard polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #3C[Si](C)(C)OC(=O)[C@@H](C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C1861.0Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #3C[Si](C)(C)OC(=O)[C@@H](C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C1885.0Standard non polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #3C[Si](C)(C)OC(=O)[C@@H](C[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C2012.1Standard polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #4C[Si](C)(C)OC(=O)[C@H](C[C@@H](O)C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1874.9Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #4C[Si](C)(C)OC(=O)[C@H](C[C@@H](O)C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1850.7Standard non polar33892256
4-Hydroxy-L-glutamic acid,4TMS,isomer #4C[Si](C)(C)OC(=O)[C@H](C[C@@H](O)C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1947.9Standard polar33892256
4-Hydroxy-L-glutamic acid,5TMS,isomer #1C[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1933.7Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,5TMS,isomer #1C[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1919.7Standard non polar33892256
4-Hydroxy-L-glutamic acid,5TMS,isomer #1C[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C1856.6Standard polar33892256
4-Hydroxy-L-glutamic acid,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@H](C[C@H](N)C(=O)O)C(=O)O1870.5Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@H](O)C[C@H](N)C(=O)O1842.1Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)C[C@@H](O)C(=O)O1844.9Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,1TBDMS,isomer #4CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O)C(=O)O)C(=O)O1888.6Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O2108.4Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@@H](C[C@H](N)C(=O)O)O[Si](C)(C)C(C)(C)C2100.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O)C(=O)O2142.4Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)C[C@@H](O)C(=O)O[Si](C)(C)C(C)(C)C2051.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O2146.9Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O)C(=O)O)C(=O)O[Si](C)(C)C(C)(C)C2134.5Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,2TBDMS,isomer #7CC(C)(C)[Si](C)(C)N([C@@H](C[C@@H](O)C(=O)O)C(=O)O)[Si](C)(C)C(C)(C)C2275.7Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C2303.0Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O)C(=O)O[Si](C)(C)C(C)(C)C2381.9Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O2383.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@H](C[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O2503.0Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TBDMS,isomer #5CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C2348.8Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC(=O)[C@H](O)C[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2503.9Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,3TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O)C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2511.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C2590.6Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C2538.7Standard non polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)N[C@@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C2405.8Standard polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2761.0Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2592.3Standard non polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2429.2Standard polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@@H](C[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C2750.2Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@@H](C[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C2610.3Standard non polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@@H](C[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C2440.7Standard polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O)C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2735.6Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O)C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2612.2Standard non polar33892256
4-Hydroxy-L-glutamic acid,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O)C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2407.3Standard polar33892256
4-Hydroxy-L-glutamic acid,5TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2973.8Semi standard non polar33892256
4-Hydroxy-L-glutamic acid,5TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2803.6Standard non polar33892256
4-Hydroxy-L-glutamic acid,5TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@H](C[C@@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2448.9Standard polar33892256
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Feces
  • Urine
Tissue Locations
  • Liver
  • Placenta
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal		 details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedCancer patients undergoing total body irradiation details
UrineDetected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedCancer patients undergoing total body irradiation details
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022938
KNApSAcK IDNot Available
Chemspider ID389696
KEGG Compound IDC05947
BioCyc IDL-ERYTHRO-4-HYDROXY-GLUTAMATE
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound440854
PDB IDNot Available
ChEBI ID21285
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceDucrocq, Claire; Decottignies-Le Marechal, Paulette; Azerad, Robert. Synthesis of L-glutamic acid stereospecifically labeled at C-4 with deuterium. Journal of Labelled Compounds and Radiopharmaceuticals (1985), 22(1), 61-70.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. GOLDSTONE A, ADAMS E: Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver. J Biol Chem. 1962 Nov;237:3476-85. [PubMed:13948827 ]
  2. Alaux S, Kusk M, Sagot E, Bolte J, Jensen AA, Brauner-Osborne H, Gefflaut T, Bunch L: Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3. J Med Chem. 2005 Dec 15;48(25):7980-92. [PubMed:16335922 ]
  3. Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Enzymes

Enzyme Details
1. Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
General function:
Involved in oxidoreductase activity
Specific function:
Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Gene Name:
ALDH4A1
Uniprot ID:
P30038
Molecular weight:
55117.24
Reactions
Pyrroline hydroxycarboxylic acid + NAD + Water → 4-Hydroxy-L-glutamic acid + NADH + Hydrogen Iondetails
Pyrroline hydroxycarboxylic acid + NADP + Water → 4-Hydroxy-L-glutamic acid + NADPH + Hydrogen Iondetails
4-Hydroxy-L-glutamic acid + NADH + Hydrogen Ion → L-4-Hydroxyglutamate semialdehyde + NAD + Waterdetails
Enzyme Details
2. Aspartate aminotransferase, cytoplasmic
General function:
Involved in transferase activity, transferring nitrogenous groups
Specific function:
Plays a key role in amino acid metabolism (By similarity).
Gene Name:
GOT1
Uniprot ID:
P17174
Molecular weight:
46247.14
Reactions
4-Hydroxy-L-glutamic acid + Oxoglutaric acid → D-4-Hydroxy-2-oxoglutarate + Glutamic aciddetails
Enzyme Details
3. Aspartate aminotransferase, mitochondrial
General function:
Involved in transferase activity, transferring nitrogenous groups
Specific function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Gene Name:
GOT2
Uniprot ID:
P00505
Molecular weight:
47517.285
Reactions
4-Hydroxy-L-glutamic acid + Oxoglutaric acid → D-4-Hydroxy-2-oxoglutarate + Glutamic aciddetails
Enzyme Details
4. Proline dehydrogenase 1, mitochondrial
General function:
Involved in proline dehydrogenase activity
Specific function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Gene Name:
PRODH
Uniprot ID:
O43272
Molecular weight:
56196.675
Reactions
4-Hydroxy-L-glutamic acid + NADH + Hydrogen Ion → L-4-Hydroxyglutamate semialdehyde + NAD + Waterdetails