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Showing metabocard for Cer(d18:1/14:0) (HMDB0011773)

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enzymes (66) Show 66 proteins
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2009-03-24 16:16:41 UTC
Update Date2022-03-07 02:51:14 UTC
HMDB IDHMDB0011773
Secondary Accession Numbers
  • HMDB11773
Metabolite Identification
Common NameCer(d18:1/14:0)
DescriptionCer(d18:1/14:0), also known as N-tetradecanoyl-sphing-4-enine, is a ceramide (Cer). Ceramides are members of the class of compounds known as sphingolipids (SPs), or glycosylceramides. SPs are lipids containing a backbone of sphingoid bases (e.g. sphingosine or sphinganine) that are often covalently bound to a fatty acid derivative through N-acylation. SPs are found in cell membranes, particularly in peripheral nerve cells and the cells found in the central nervous system (including the brain and spinal cord). Sphingolipids are extremely versatile molecules that have functions controlling fundamental cellular processes such as cell division, differentiation, and cell death. Impairments associated with sphingolipid metabolism are associated with many common human diseases such as diabetes, various cancers, microbial infections, diseases of the cardiovascular and respiratory systems, Alzheimer’s disease and other neurological syndromes. The biosynthesis and catabolism of sphingolipids involves a large number of intermediate metabolites where many different enzymes are involved. Simple sphingolipids, which include the sphingoid bases and ceramides, make up the early products of the sphingolipid synthetic pathways, while complex sphingolipids may be formed by the addition of head groups to the ceramide template (Wikipedia). In humans, ceramides are phosphorylated to ceramide phosphates (CerPs) through the action of a specific ceramide kinase (CerK). Ceramide phosphates are important metabolites of ceramides as they act as a mediators of the inflammatory response. Ceramides are also one of the hydrolysis byproducts of sphingomyelins (SMs) through the action of the enzyme sphingomyelin phosphodiesterase, which has been identified in the subcellular fractions of human epidermis (PMID: 25935 ) and many other tissues. Ceramides can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis (PMID: 14998372 ). Ceramides are key in the biosynthesis of glycosphingolipids and gangliosides. In terms of its appearance and structure, Cer(d18:1/14:0) is a colorless solid that consists of an unsaturated 18-carbon sphingoid base with an attached saturated tetradecanoyl fatty acid side chain. In most mammalian SPs, the 18-carbon sphingoid bases are predominant (PMID: 9759481 ).
Structure
Data?1582752950
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0011773 (Cer(d18:1/14:0))


  Mrv0541 02241201542D          

 36 35  0  0  1  0            999 V2000
   19.1778   -3.3315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.4587   -2.9270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.7488   -3.3474    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   17.0298   -2.9429    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   16.3199   -3.3634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6009   -2.9589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8911   -3.3794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1720   -2.9749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4621   -3.3954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7431   -2.9909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0333   -3.4114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3142   -3.0069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6044   -3.4273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8853   -3.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1755   -3.4433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4564   -3.0388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7466   -3.4593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0276   -3.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0206   -2.1179    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.7581   -4.1724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3176   -3.4752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1843   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8988   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6133   -4.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3278   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   17.0436   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0436   -5.4099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4698   -4.5849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7553   -4.1725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
Download

3D MOL for HMDB0011773 (Cer(d18:1/14:0))

HMDB0011773
     RDKit          3D
Cer(d18:1/14:0)
 99 98  0  0  0  0  0  0  0  0999 V2000
   11.8801   -0.8912    1.0741 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0907   -1.4577    2.1987 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5806   -0.5423    3.2134 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5973    0.4977    3.0134 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6740    1.6774    2.1787 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8169    1.6362    0.7448 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8474    0.9538   -0.1565 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4790    1.4229   -0.2433 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4761    1.3702    0.7941 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9636    0.0731    1.2964 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2909   -0.7816    0.2555 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1059   -0.1395   -0.3889 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3963    1.2602   -1.1046 H   0  0  0  0  0  0  0  0  0  0  0  0
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    0.9219    3.1425    0.8475 H   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
Download

3D SDF for HMDB0011773 (Cer(d18:1/14:0))


  Mrv0541 02241201542D          

 36 35  0  0  1  0            999 V2000
   19.1778   -3.3315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.4587   -2.9270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 33  1  0  0  0  0
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M  END
> <DATABASE_ID>
HMDB0011773

> <DATABASE_NAME>
hmdb

> <SMILES>
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCC

> <INCHI_IDENTIFIER>
InChI=1S/C32H63NO3/c1-3-5-7-9-11-13-15-16-18-19-21-23-25-27-31(35)30(29-34)33-32(36)28-26-24-22-20-17-14-12-10-8-6-4-2/h25,27,30-31,34-35H,3-24,26,28-29H2,1-2H3,(H,33,36)/b27-25+/t30-,31+/m0/s1

> <INCHI_KEY>
ZKRPGPZHULJLKJ-JHRQRACZSA-N

> <FORMULA>
C32H63NO3

> <MOLECULAR_WEIGHT>
509.8475

> <EXACT_MASS>
509.480794887

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_AVERAGE_POLARIZABILITY>
68.54644155941533

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetradecanamide

> <ALOGPS_LOGP>
9.10

> <JCHEM_LOGP>
9.976217813666667

> <ALOGPS_LOGS>
-6.94

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.235174526466391

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.619749059447084

> <JCHEM_PKA_STRONGEST_BASIC>
0.01986668903336941

> <JCHEM_POLAR_SURFACE_AREA>
69.56

> <JCHEM_REFRACTIVITY>
156.57370000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
28

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
5.83e-05 g/l

> <JCHEM_TRADITIONAL_IUPAC>
C14 cer

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0011773 (Cer(d18:1/14:0))

HMDB0011773
     RDKit          3D
Cer(d18:1/14:0)
 99 98  0  0  0  0  0  0  0  0999 V2000
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M  END
Download

PDB for HMDB0011773 (Cer(d18:1/14:0))

HEADER    PROTEIN                                 24-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-FEB-12         0                                  
HETATM    1  O   UNK     0      35.799  -6.219   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0      34.456  -5.464   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      33.131  -6.248   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      31.789  -5.493   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      30.464  -6.278   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      29.122  -5.523   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      27.797  -6.308   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      26.454  -5.553   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      25.129  -6.338   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      23.787  -5.583   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      22.462  -6.368   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      21.120  -5.613   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      19.795  -6.398   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      18.453  -5.643   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      17.128  -6.427   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      15.785  -5.672   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      14.460  -6.457   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      13.118  -5.702   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      31.772  -3.953   0.000  0.00  0.00           O+0
HETATM   20  N   UNK     0      33.148  -7.788   0.000  0.00  0.00           N+0
HETATM   21  C   UNK     0      11.793  -6.487   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      17.144  -7.788   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      18.478  -8.558   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      19.811  -7.788   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      21.145  -8.558   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      22.479  -7.788   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      23.813  -8.558   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      25.146  -7.788   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      26.480  -8.558   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      27.814  -7.788   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      29.147  -8.558   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      30.481  -7.788   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      31.815  -8.558   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0      31.815 -10.098   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0      15.810  -8.558   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      14.477  -7.789   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   20                                                  
CONECT    4    3    5   19                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   21                                                       
CONECT   19    4                                                            
CONECT   20    3   33                                                       
CONECT   21   18                                                            
CONECT   22   23   35                                                       
CONECT   23   22   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   33                                                       
CONECT   33   32   20   34                                                  
CONECT   34   33                                                            
CONECT   35   22   36                                                       
CONECT   36   35                                                            
MASTER        0    0    0    0    0    0    0    0   36    0   70    0
END
Download

3D PDB for HMDB0011773 (Cer(d18:1/14:0))

COMPND    HMDB0011773
HETATM    1  C1  UNL     1      11.880  -0.891   1.074  1.00  0.00           C  
HETATM    2  C2  UNL     1      11.091  -1.458   2.199  1.00  0.00           C  
HETATM    3  C3  UNL     1      10.581  -0.542   3.213  1.00  0.00           C  
HETATM    4  C4  UNL     1       9.597   0.498   3.013  1.00  0.00           C  
HETATM    5  C5  UNL     1       9.674   1.677   2.179  1.00  0.00           C  
HETATM    6  C6  UNL     1       9.817   1.636   0.745  1.00  0.00           C  
HETATM    7  C7  UNL     1       8.847   0.954  -0.156  1.00  0.00           C  
HETATM    8  C8  UNL     1       7.479   1.423  -0.243  1.00  0.00           C  
HETATM    9  C9  UNL     1       6.476   1.370   0.794  1.00  0.00           C  
HETATM   10  C10 UNL     1       5.964   0.073   1.296  1.00  0.00           C  
HETATM   11  C11 UNL     1       5.291  -0.782   0.255  1.00  0.00           C  
HETATM   12  C12 UNL     1       4.106  -0.139  -0.389  1.00  0.00           C  
HETATM   13  C13 UNL     1       3.535  -1.124  -1.396  1.00  0.00           C  
HETATM   14  C14 UNL     1       2.361  -0.590  -2.099  1.00  0.00           C  
HETATM   15  C15 UNL     1       1.926   0.629  -1.822  1.00  0.00           C  
HETATM   16  C16 UNL     1       0.724   1.151  -2.554  1.00  0.00           C  
HETATM   17  O1  UNL     1       0.205   0.111  -3.344  1.00  0.00           O  
HETATM   18  C17 UNL     1      -0.293   1.648  -1.573  1.00  0.00           C  
HETATM   19  C18 UNL     1       0.154   2.940  -0.968  1.00  0.00           C  
HETATM   20  O2  UNL     1       1.177   2.862  -0.064  1.00  0.00           O  
HETATM   21  N1  UNL     1      -0.750   0.676  -0.629  1.00  0.00           N  
HETATM   22  C19 UNL     1      -2.068   0.137  -0.576  1.00  0.00           C  
HETATM   23  O3  UNL     1      -2.876   0.554  -1.431  1.00  0.00           O  
HETATM   24  C20 UNL     1      -2.488  -0.853   0.412  1.00  0.00           C  
HETATM   25  C21 UNL     1      -3.894  -1.402   0.185  1.00  0.00           C  
HETATM   26  C22 UNL     1      -4.026  -2.120  -1.094  1.00  0.00           C  
HETATM   27  C23 UNL     1      -5.259  -2.792  -1.483  1.00  0.00           C  
HETATM   28  C24 UNL     1      -6.551  -2.121  -1.638  1.00  0.00           C  
HETATM   29  C25 UNL     1      -7.177  -1.531  -0.425  1.00  0.00           C  
HETATM   30  C26 UNL     1      -8.532  -0.857  -0.742  1.00  0.00           C  
HETATM   31  C27 UNL     1      -9.530  -1.776  -1.306  1.00  0.00           C  
HETATM   32  C28 UNL     1     -10.832  -1.156  -1.627  1.00  0.00           C  
HETATM   33  C29 UNL     1     -11.683  -0.675  -0.553  1.00  0.00           C  
HETATM   34  C30 UNL     1     -11.290   0.351   0.416  1.00  0.00           C  
HETATM   35  C31 UNL     1     -12.571   0.619   1.287  1.00  0.00           C  
HETATM   36  C32 UNL     1     -12.262   1.659   2.313  1.00  0.00           C  
HETATM   37  H1  UNL     1      11.264  -0.766   0.170  1.00  0.00           H  
HETATM   38  H2  UNL     1      12.364   0.043   1.381  1.00  0.00           H  
HETATM   39  H3  UNL     1      12.754  -1.572   0.799  1.00  0.00           H  
HETATM   40  H4  UNL     1      10.265  -2.149   1.799  1.00  0.00           H  
HETATM   41  H5  UNL     1      11.791  -2.191   2.722  1.00  0.00           H  
HETATM   42  H6  UNL     1      10.172  -1.190   4.099  1.00  0.00           H  
HETATM   43  H7  UNL     1      11.493  -0.062   3.756  1.00  0.00           H  
HETATM   44  H8  UNL     1       9.419   0.928   4.107  1.00  0.00           H  
HETATM   45  H9  UNL     1       8.560   0.021   2.855  1.00  0.00           H  
HETATM   46  H10 UNL     1      10.595   2.296   2.572  1.00  0.00           H  
HETATM   47  H11 UNL     1       8.863   2.444   2.456  1.00  0.00           H  
HETATM   48  H12 UNL     1       9.724   2.815   0.438  1.00  0.00           H  
HETATM   49  H13 UNL     1      10.883   1.534   0.420  1.00  0.00           H  
HETATM   50  H14 UNL     1       9.333   1.013  -1.195  1.00  0.00           H  
HETATM   51  H15 UNL     1       8.955  -0.147   0.064  1.00  0.00           H  
HETATM   52  H16 UNL     1       7.025   1.012  -1.227  1.00  0.00           H  
HETATM   53  H17 UNL     1       7.551   2.534  -0.566  1.00  0.00           H  
HETATM   54  H18 UNL     1       6.748   1.964   1.698  1.00  0.00           H  
HETATM   55  H19 UNL     1       5.539   1.937   0.437  1.00  0.00           H  
HETATM   56  H20 UNL     1       6.662  -0.546   1.868  1.00  0.00           H  
HETATM   57  H21 UNL     1       5.144   0.329   2.039  1.00  0.00           H  
HETATM   58  H22 UNL     1       6.026  -1.020  -0.541  1.00  0.00           H  
HETATM   59  H23 UNL     1       4.972  -1.750   0.690  1.00  0.00           H  
HETATM   60  H24 UNL     1       4.444   0.738  -0.988  1.00  0.00           H  
HETATM   61  H25 UNL     1       3.292   0.104   0.315  1.00  0.00           H  
HETATM   62  H26 UNL     1       4.298  -1.463  -2.127  1.00  0.00           H  
HETATM   63  H27 UNL     1       3.202  -2.066  -0.868  1.00  0.00           H  
HETATM   64  H28 UNL     1       1.849  -1.175  -2.836  1.00  0.00           H  
HETATM   65  H29 UNL     1       2.396   1.260  -1.105  1.00  0.00           H  
HETATM   66  H30 UNL     1       0.990   1.973  -3.239  1.00  0.00           H  
HETATM   67  H31 UNL     1       0.432   0.218  -4.285  1.00  0.00           H  
HETATM   68  H32 UNL     1      -1.233   1.875  -2.207  1.00  0.00           H  
HETATM   69  H33 UNL     1      -0.740   3.353  -0.411  1.00  0.00           H  
HETATM   70  H34 UNL     1       0.352   3.681  -1.779  1.00  0.00           H  
HETATM   71  H35 UNL     1       0.922   3.142   0.847  1.00  0.00           H  
HETATM   72  H36 UNL     1      -0.068   0.328   0.085  1.00  0.00           H  
HETATM   73  H37 UNL     1      -2.502  -0.416   1.436  1.00  0.00           H  
HETATM   74  H38 UNL     1      -1.772  -1.716   0.456  1.00  0.00           H  
HETATM   75  H39 UNL     1      -4.211  -1.891   1.090  1.00  0.00           H  
HETATM   76  H40 UNL     1      -4.500  -0.440   0.076  1.00  0.00           H  
HETATM   77  H41 UNL     1      -3.615  -1.506  -1.968  1.00  0.00           H  
HETATM   78  H42 UNL     1      -3.218  -2.948  -1.055  1.00  0.00           H  
HETATM   79  H43 UNL     1      -5.004  -3.371  -2.451  1.00  0.00           H  
HETATM   80  H44 UNL     1      -5.456  -3.703  -0.791  1.00  0.00           H  
HETATM   81  H45 UNL     1      -7.280  -2.939  -1.982  1.00  0.00           H  
HETATM   82  H46 UNL     1      -6.592  -1.417  -2.517  1.00  0.00           H  
HETATM   83  H47 UNL     1      -7.371  -2.346   0.335  1.00  0.00           H  
HETATM   84  H48 UNL     1      -6.624  -0.758   0.110  1.00  0.00           H  
HETATM   85  H49 UNL     1      -8.823  -0.390   0.171  1.00  0.00           H  
HETATM   86  H50 UNL     1      -8.268  -0.105  -1.531  1.00  0.00           H  
HETATM   87  H51 UNL     1      -9.768  -2.634  -0.582  1.00  0.00           H  
HETATM   88  H52 UNL     1      -9.133  -2.337  -2.209  1.00  0.00           H  
HETATM   89  H53 UNL     1     -10.579  -0.248  -2.305  1.00  0.00           H  
HETATM   90  H54 UNL     1     -11.423  -1.824  -2.355  1.00  0.00           H  
HETATM   91  H55 UNL     1     -12.658  -0.321  -1.034  1.00  0.00           H  
HETATM   92  H56 UNL     1     -12.058  -1.567   0.091  1.00  0.00           H  
HETATM   93  H57 UNL     1     -10.563   0.013   1.214  1.00  0.00           H  
HETATM   94  H58 UNL     1     -10.921   1.311   0.039  1.00  0.00           H  
HETATM   95  H59 UNL     1     -12.868  -0.314   1.777  1.00  0.00           H  
HETATM   96  H60 UNL     1     -13.338   1.011   0.598  1.00  0.00           H  
HETATM   97  H61 UNL     1     -12.327   1.206   3.322  1.00  0.00           H  
HETATM   98  H62 UNL     1     -12.966   2.519   2.314  1.00  0.00           H  
HETATM   99  H63 UNL     1     -11.205   2.045   2.239  1.00  0.00           H  
CONECT    1    2   37   38   39
CONECT    2    3   40   41
CONECT    3    4   42   43
CONECT    4    5   44   45
CONECT    5    6   46   47
CONECT    6    7   48   49
CONECT    7    8   50   51
CONECT    8    9   52   53
CONECT    9   10   54   55
CONECT   10   11   56   57
CONECT   11   12   58   59
CONECT   12   13   60   61
CONECT   13   14   62   63
CONECT   14   15   15   64
CONECT   15   16   65
CONECT   16   17   18   66
CONECT   17   67
CONECT   18   19   21   68
CONECT   19   20   69   70
CONECT   20   71
CONECT   21   22   72
CONECT   22   23   23   24
CONECT   24   25   73   74
CONECT   25   26   75   76
CONECT   26   27   77   78
CONECT   27   28   79   80
CONECT   28   29   81   82
CONECT   29   30   83   84
CONECT   30   31   85   86
CONECT   31   32   87   88
CONECT   32   33   89   90
CONECT   33   34   91   92
CONECT   34   35   93   94
CONECT   35   36   95   96
CONECT   36   97   98   99
END
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SMILES for HMDB0011773 (Cer(d18:1/14:0))

CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCC
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INCHI for HMDB0011773 (Cer(d18:1/14:0))

InChI=1S/C32H63NO3/c1-3-5-7-9-11-13-15-16-18-19-21-23-25-27-31(35)30(29-34)33-32(36)28-26-24-22-20-17-14-12-10-8-6-4-2/h25,27,30-31,34-35H,3-24,26,28-29H2,1-2H3,(H,33,36)/b27-25+/t30-,31+/m0/s1
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View in JSmolView Stereo Labels
Synonyms
ValueSource
C14 CerChEBI
N-(Myristoyl)ceramideChEBI
N-(Tetradecanoyl)ceramideChEBI
N-(Tetradecanoyl)sphing-4-enineChEBI
N-Myristoylsphing-4-enineChEBI
N-MyristoylsphingosineChEBI
N-Tetradecanoylsphing-4-enineChEBI
CeramideMetBuilder
N-(Tetradecanoyl)-sphing-4-enineMetBuilder
Ceramide(D18:1/14:0)MetBuilder
N-(Tetradecanoyl)-sphingosineMetBuilder
N-(Tetradecanoyl)-D-erythro-sphingosineMetBuilder
N-(Tetradecanoyl)-4-sphingenineMetBuilder
N-(Tetradecanoyl)-D-sphingosineMetBuilder
N-(Tetradecanoyl)-sphingenineMetBuilder
N-(Tetradecanoyl)-erythro-4-sphingenineMetBuilder
Chemical FormulaC32H63NO3
Average Molecular Weight509.8475
Monoisotopic Molecular Weight509.480794887
IUPAC NameN-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetradecanamide
Traditional NameC14 cer
CAS Registry NumberNot Available
SMILES
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCC
InChI Identifier
InChI=1S/C32H63NO3/c1-3-5-7-9-11-13-15-16-18-19-21-23-25-27-31(35)30(29-34)33-32(36)28-26-24-22-20-17-14-12-10-8-6-4-2/h25,27,30-31,34-35H,3-24,26,28-29H2,1-2H3,(H,33,36)/b27-25+/t30-,31+/m0/s1
InChI KeyZKRPGPZHULJLKJ-JHRQRACZSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as long-chain ceramides. These are ceramides bearing a long chain fatty acid.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSphingolipids
Sub ClassCeramides
Direct ParentLong-chain ceramides
Alternative Parents
Substituents
  • Long-chain ceramide
  • Fatty amide
  • N-acyl-amine
  • Fatty acyl
  • Carboxamide group
  • Secondary alcohol
  • Secondary carboxylic acid amide
  • Carboxylic acid derivative
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Alcohol
  • Organic nitrogen compound
  • Carbonyl group
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect
Health effectOrganoleptic effect
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Biological roleIndustrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility5.8e-05 g/LALOGPS
logP9.1ALOGPS
logP9.98ChemAxon
logS-6.9ALOGPS
pKa (Strongest Acidic)13.62ChemAxon
pKa (Strongest Basic)0.02ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area69.56 ŲChemAxon
Rotatable Bond Count28ChemAxon
Refractivity156.57 m³·mol⁻¹ChemAxon
Polarizability68.55 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+233.94831661259
DarkChem[M-H]-229.94931661259
DeepCCS[M+H]+235.13630932474
DeepCCS[M-H]-232.77830932474
DeepCCS[M-2H]-266.80530932474
DeepCCS[M+Na]+242.03530932474
AllCCS[M+H]+247.532859911
AllCCS[M+H-H2O]+246.532859911
AllCCS[M+NH4]+248.432859911
AllCCS[M+Na]+248.732859911
AllCCS[M-H]-233.332859911
AllCCS[M+Na-2H]-236.732859911
AllCCS[M+HCOO]-240.532859911

Predicted Retention Times

Underivatized

Chromatographic MethodRetention TimeReference
Measured using a Waters Acquity ultraperformance liquid chromatography (UPLC) ethylene-bridged hybrid (BEH) C18 column (100 mm × 2.1 mm; 1.7 μmparticle diameter). Predicted by Afia on May 17, 2022. Predicted by Afia on May 17, 2022.9.6 minutes32390414
Predicted by Siyang on May 30, 202231.1187 minutes33406817
Predicted by Siyang using ReTip algorithm on June 8, 20221.84 minutes32390414
AjsUoB = Accucore 150 Amide HILIC with 10mM Ammonium Formate, 0.1% Formic Acid57.8 seconds40023050
Fem_Long = Waters ACQUITY UPLC HSS T3 C18 with Water:MeOH and 0.1% Formic Acid4440.6 seconds40023050
Fem_Lipids = Ascentis Express C18 with (60:40 water:ACN):(90:10 IPA:ACN) and 10mM NH4COOH + 0.1% Formic Acid589.5 seconds40023050
Life_Old = Waters ACQUITY UPLC BEH C18 with Water:(20:80 acetone:ACN) and 0.1% Formic Acid327.3 seconds40023050
Life_New = RP Waters ACQUITY UPLC HSS T3 C18 with Water:(30:70 MeOH:ACN) and 0.1% Formic Acid270.8 seconds40023050
RIKEN = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid858.9 seconds40023050
Eawag_XBridgeC18 = XBridge C18 3.5u 2.1x50 mm with Water:MeOH and 0.1% Formic Acid1375.6 seconds40023050
BfG_NTS_RP1 =Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) with Water:ACN and 0.1% Formic Acid1078.8 seconds40023050
HILIC_BDD_2 = Merck SeQuant ZIC-HILIC with ACN(0.1% formic acid):water(16 mM ammonium formate)158.8 seconds40023050
UniToyama_Atlantis = RP Waters Atlantis T3 (2.1 x 150 mm, 5 um) with ACN:Water and 0.1% Formic Acid3077.6 seconds40023050
BDD_C18 = Hypersil Gold 1.9µm C18 with Water:ACN and 0.1% Formic Acid909.8 seconds40023050
UFZ_Phenomenex = Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex with Water:MeOH and 0.1% Formic Acid2592.3 seconds40023050
SNU_RIKEN_POS = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid1043.5 seconds40023050
RPMMFDA = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid656.7 seconds40023050
MTBLS87 = Merck SeQuant ZIC-pHILIC column with ACN:Water and :ammonium carbonate648.6 seconds40023050
KI_GIAR_zic_HILIC_pH2_7 = Merck SeQuant ZIC-HILIC with ACN:Water and 0.1% FA546.5 seconds40023050
Meister zic-pHILIC pH9.3 = Merck SeQuant ZIC-pHILIC column with ACN:Water 5mM NH4Ac pH9.3 and 5mM ammonium acetate in water9.3 seconds40023050

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Cer(d18:1/14:0)CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCC3450.9Standard polar33892256
Cer(d18:1/14:0)CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCC3629.8Standard non polar33892256
Cer(d18:1/14:0)CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCC4037.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Cer(d18:1/14:0),1TMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C)[C@H](CO)NC(=O)CCCCCCCCCCCCC3858.5Semi standard non polar33892256
Cer(d18:1/14:0),1TMS,isomer #2CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[Si](C)(C)C)NC(=O)CCCCCCCCCCCCC3817.6Semi standard non polar33892256
Cer(d18:1/14:0),1TMS,isomer #3CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C3783.3Semi standard non polar33892256
Cer(d18:1/14:0),2TMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C)[C@H](CO[Si](C)(C)C)NC(=O)CCCCCCCCCCCCC3864.7Semi standard non polar33892256
Cer(d18:1/14:0),2TMS,isomer #2CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C)[C@H](CO)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C3861.1Semi standard non polar33892256
Cer(d18:1/14:0),2TMS,isomer #3CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[Si](C)(C)C)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C3826.5Semi standard non polar33892256
Cer(d18:1/14:0),3TMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C)[C@H](CO[Si](C)(C)C)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C3874.3Semi standard non polar33892256
Cer(d18:1/14:0),3TMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C)[C@H](CO[Si](C)(C)C)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C3687.7Standard non polar33892256
Cer(d18:1/14:0),3TMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C)[C@H](CO[Si](C)(C)C)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C3733.7Standard polar33892256
Cer(d18:1/14:0),1TBDMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO)NC(=O)CCCCCCCCCCCCC4129.1Semi standard non polar33892256
Cer(d18:1/14:0),1TBDMS,isomer #2CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[Si](C)(C)C(C)(C)C)NC(=O)CCCCCCCCCCCCC4099.0Semi standard non polar33892256
Cer(d18:1/14:0),1TBDMS,isomer #3CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C4034.5Semi standard non polar33892256
Cer(d18:1/14:0),2TBDMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO[Si](C)(C)C(C)(C)C)NC(=O)CCCCCCCCCCCCC4383.0Semi standard non polar33892256
Cer(d18:1/14:0),2TBDMS,isomer #2CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C4312.3Semi standard non polar33892256
Cer(d18:1/14:0),2TBDMS,isomer #3CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C4287.0Semi standard non polar33892256
Cer(d18:1/14:0),3TBDMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C4596.5Semi standard non polar33892256
Cer(d18:1/14:0),3TBDMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C4121.7Standard non polar33892256
Cer(d18:1/14:0),3TBDMS,isomer #1CCCCCCCCCCCCC/C=C/[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)CCCCCCCCCCCCC)[Si](C)(C)C(C)(C)C3939.6Standard polar33892256
Spectra
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.012 +/- 0.001 uMAdult (>18 years old)BothNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB028443
KNApSAcK IDNot Available
Chemspider ID4445481
KEGG Compound IDC13916
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound5282310
PDB IDNot Available
ChEBI ID72957
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Bowser PA, Gray GM: Sphingomyelinase in pig and human epidermis. J Invest Dermatol. 1978 Jun;70(6):331-5. [PubMed:25935 ]
  2. Tserng KY, Griffin RL: Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. Biochem J. 2004 Jun 15;380(Pt 3):715-22. [PubMed:14998372 ]
  3. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
  4. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
  5. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
  6. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
  7. Divecha N, Irvine RF: Phospholipid signaling. Cell. 1995 Jan 27;80(2):269-78. [PubMed:7834746 ]
  8. Ghosh S, Strum JC, Bell RM: Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling. FASEB J. 1997 Jan;11(1):45-50. [PubMed:9034165 ]
  9. Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC, Merrill AH Jr: Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res. 2008 Aug;49(8):1621-39. doi: 10.1194/jlr.R800012-JLR200. Epub 2008 May 21. [PubMed:18499644 ]
  10. Hannun YA, Obeid LM: Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci. 1995 Feb;20(2):73-7. [PubMed:7701566 ]
  11. Cevc, Gregor (1993). Phospholipids Handbook. Marcel Dekker.
  12. Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.

Only showing the first 10 proteins. There are 66 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Galactocerebrosidase
General function:
Involved in galactosylceramidase activity
Specific function:
Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Gene Name:
GALC
Uniprot ID:
P54803
Molecular weight:
77062.86
Enzyme Details
2. Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens
Gene Name:
GBGT1
Uniprot ID:
Q8N5D6
Molecular weight:
40126.9
Enzyme Details
3. N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
General function:
Involved in N-acetylglucosaminylphosphatidylinositol de
Specific function:
Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.
Gene Name:
PIGL
Uniprot ID:
Q9Y2B2
Molecular weight:
28530.965
Enzyme Details
4. Phosphatidylcholine:ceramide cholinephosphotransferase 2
General function:
Involved in catalytic activity
Specific function:
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Required for cell growth
Gene Name:
SGMS2
Uniprot ID:
Q8NHU3
Molecular weight:
42279.8
Enzyme Details
5. Phosphatidylcholine:ceramide cholinephosphotransferase 1
General function:
Involved in catalytic activity
Specific function:
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth
Gene Name:
SGMS1
Uniprot ID:
Q86VZ5
Molecular weight:
49207.3
Enzyme Details
6. Sphingomyelin phosphodiesterase
General function:
Involved in hydrolase activity
Specific function:
Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.
Gene Name:
SMPD1
Uniprot ID:
P17405
Molecular weight:
69935.53
Enzyme Details
7. Ceramide glucosyltransferase
General function:
Cell wall/membrane/envelope biogenesis
Specific function:
Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".
Gene Name:
UGCG
Uniprot ID:
Q16739
Molecular weight:
44853.255
Enzyme Details
8. Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
General function:
Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity
Specific function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Gene Name:
PIGQ
Uniprot ID:
Q9BRB3
Molecular weight:
65343.25
Enzyme Details
9. Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
General function:
Involved in biosynthetic process
Specific function:
Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
Gene Name:
PIGA
Uniprot ID:
P37287
Molecular weight:
54126.065
Enzyme Details
10. Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
General function:
Involved in phosphatidylinositol N-acetylglucosaminyltr
Specific function:
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Gene Name:
PIGH
Uniprot ID:
Q14442
Molecular weight:
21080.415

Only showing the first 10 proteins. There are 66 proteins in total.

Show all enzymes and transporters