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Showing metabocard for Phentermine (HMDB0014337)

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enzymes (6)transporters (2) Show 8 proteins
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:49 UTC
Update Date2023-02-21 17:18:08 UTC
HMDB IDHMDB0014337
Secondary Accession Numbers
  • HMDB14337
Metabolite Identification
Common NamePhentermine
DescriptionPhentermine is only found in individuals that have used or taken this drug. It is a central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and seratonin through inhibition or reversal of the reuptake transporters. It may also inhibit MAO enzymes leaving more neurotransmitter available at the synapse.Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.
Structure
Data?1676999888
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0014337 (Phentermine)

191
  Mrv1652305271900252D          

 11 11  0  0  0  0            999 V2000
    3.7935    1.3943    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791    0.9818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.5693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6665    1.6962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4916    0.2673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.2558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -0.6683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.6683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -1.4933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.4933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.9058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  9 11  2  0  0  0  0
 10 11  1  0  0  0  0
M  END
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3D MOL for HMDB0014337 (Phentermine)

HMDB0014337
     RDKit          3D
Phentermine
 26 26  0  0  0  0  0  0  0  0999 V2000
   -2.9319    0.6175    0.1376 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5372    0.0845   -0.1106 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4497   -1.3338    0.3507 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3683    0.0686   -1.5722 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4969    0.9815    0.4750 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8732    0.5361    0.2784 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5870    0.9164   -0.8304 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9084    0.4884   -1.0203 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4892   -0.3250   -0.0750 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7803   -0.7013    1.0238 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4902   -0.2752    1.1958 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1523    1.5281   -0.4328 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6673   -0.1845   -0.1421 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0761    0.8267    1.2379 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4109   -1.7084    0.4357 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9086   -1.4584    1.3693 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9751   -2.0467   -0.3118 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7637   -0.7250   -1.8335 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3030   -0.1007   -2.0315 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6863    2.0203    0.0864 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7319    1.0675    1.5776 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1933    1.5486   -1.6040 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4805    0.7823   -1.8910 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5260   -0.6845   -0.1852 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2239   -1.3480    1.7875 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9075   -0.5749    2.0846 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  1 12  1  0
  1 13  1  0
  1 14  1  0
  3 15  1  0
  3 16  1  0
  3 17  1  0
  4 18  1  0
  4 19  1  0
  5 20  1  0
  5 21  1  0
  7 22  1  0
  8 23  1  0
  9 24  1  0
 10 25  1  0
 11 26  1  0
M  END
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3D SDF for HMDB0014337 (Phentermine)

191
  Mrv1652305271900252D          

 11 11  0  0  0  0            999 V2000
    3.7935    1.3943    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791    0.9818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.5693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6665    1.6962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4916    0.2673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.2558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -0.6683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.6683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0791   -1.4933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.4933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.9058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  9 11  2  0  0  0  0
 10 11  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0014337

> <DATABASE_NAME>
hmdb

> <SMILES>
CC(C)(N)CC1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3

> <INCHI_KEY>
DHHVAGZRUROJKS-UHFFFAOYSA-N

> <FORMULA>
C10H15N

> <MOLECULAR_WEIGHT>
149.2328

> <EXACT_MASS>
149.120449485

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
26

> <JCHEM_AVERAGE_POLARIZABILITY>
17.874968045284582

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-methyl-1-phenylpropan-2-amine

> <ALOGPS_LOGP>
2.32

> <JCHEM_LOGP>
2.0848271499999997

> <ALOGPS_LOGS>
-2.29

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_BASIC>
10.248513745149388

> <JCHEM_POLAR_SURFACE_AREA>
26.02

> <JCHEM_REFRACTIVITY>
48.34340000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
7.57e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
phentermine

> <JCHEM_VEBER_RULE>
1

$$$$
Download

3D-SDF for HMDB0014337 (Phentermine)

HMDB0014337
     RDKit          3D
Phentermine
 26 26  0  0  0  0  0  0  0  0999 V2000
   -2.9319    0.6175    0.1376 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5372    0.0845   -0.1106 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4497   -1.3338    0.3507 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3683    0.0686   -1.5722 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4969    0.9815    0.4750 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8732    0.5361    0.2784 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5870    0.9164   -0.8304 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9084    0.4884   -1.0203 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4892   -0.3250   -0.0750 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7803   -0.7013    1.0238 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4902   -0.2752    1.1958 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1523    1.5281   -0.4328 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6673   -0.1845   -0.1421 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0761    0.8267    1.2379 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4109   -1.7084    0.4357 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9086   -1.4584    1.3693 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9751   -2.0467   -0.3118 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7637   -0.7250   -1.8335 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3030   -0.1007   -2.0315 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6863    2.0203    0.0864 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7319    1.0675    1.5776 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1933    1.5486   -1.6040 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4805    0.7823   -1.8910 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5260   -0.6845   -0.1852 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2239   -1.3480    1.7875 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9075   -0.5749    2.0846 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11  6  1  0
  1 12  1  0
  1 13  1  0
  1 14  1  0
  3 15  1  0
  3 16  1  0
  3 17  1  0
  4 18  1  0
  4 19  1  0
  5 20  1  0
  5 21  1  0
  7 22  1  0
  8 23  1  0
  9 24  1  0
 10 25  1  0
 11 26  1  0
M  END
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PDB for HMDB0014337 (Phentermine)

HEADER    PROTEIN                                 27-MAY-19   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: 191                                               
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-19         0                                  
HETATM    1  N   UNK     0       7.081   2.603   0.000  0.00  0.00           N+0
HETATM    2  C   UNK     0       5.748   1.833   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       4.414   1.063   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.977   3.166   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.518   0.499   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       4.414  -0.477   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.748  -1.247   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.080  -1.247   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.748  -2.787   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.080  -2.787   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.414  -3.557   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4    5                                             
CONECT    3    2    6                                                       
CONECT    4    2                                                            
CONECT    5    2                                                            
CONECT    6    3    7    8                                                  
CONECT    7    6    9                                                       
CONECT    8    6   10                                                       
CONECT    9    7   11                                                       
CONECT   10    8   11                                                       
CONECT   11    9   10                                                       
MASTER        0    0    0    0    0    0    0    0   11    0   22    0
END
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3D PDB for HMDB0014337 (Phentermine)

COMPND    HMDB0014337
HETATM    1  C1  UNL     1      -2.932   0.618   0.138  1.00  0.00           C  
HETATM    2  C2  UNL     1      -1.537   0.085  -0.111  1.00  0.00           C  
HETATM    3  C3  UNL     1      -1.450  -1.334   0.351  1.00  0.00           C  
HETATM    4  N1  UNL     1      -1.368   0.069  -1.572  1.00  0.00           N  
HETATM    5  C4  UNL     1      -0.497   0.981   0.475  1.00  0.00           C  
HETATM    6  C5  UNL     1       0.873   0.536   0.278  1.00  0.00           C  
HETATM    7  C6  UNL     1       1.587   0.916  -0.830  1.00  0.00           C  
HETATM    8  C7  UNL     1       2.908   0.488  -1.020  1.00  0.00           C  
HETATM    9  C8  UNL     1       3.489  -0.325  -0.075  1.00  0.00           C  
HETATM   10  C9  UNL     1       2.780  -0.701   1.024  1.00  0.00           C  
HETATM   11  C10 UNL     1       1.490  -0.275   1.196  1.00  0.00           C  
HETATM   12  H1  UNL     1      -3.152   1.528  -0.433  1.00  0.00           H  
HETATM   13  H2  UNL     1      -3.667  -0.185  -0.142  1.00  0.00           H  
HETATM   14  H3  UNL     1      -3.076   0.827   1.238  1.00  0.00           H  
HETATM   15  H4  UNL     1      -0.411  -1.708   0.436  1.00  0.00           H  
HETATM   16  H5  UNL     1      -1.909  -1.458   1.369  1.00  0.00           H  
HETATM   17  H6  UNL     1      -1.975  -2.047  -0.312  1.00  0.00           H  
HETATM   18  H7  UNL     1      -0.764  -0.725  -1.833  1.00  0.00           H  
HETATM   19  H8  UNL     1      -2.303  -0.101  -2.032  1.00  0.00           H  
HETATM   20  H9  UNL     1      -0.686   2.020   0.086  1.00  0.00           H  
HETATM   21  H10 UNL     1      -0.732   1.067   1.578  1.00  0.00           H  
HETATM   22  H11 UNL     1       1.193   1.549  -1.604  1.00  0.00           H  
HETATM   23  H12 UNL     1       3.480   0.782  -1.891  1.00  0.00           H  
HETATM   24  H13 UNL     1       4.526  -0.685  -0.185  1.00  0.00           H  
HETATM   25  H14 UNL     1       3.224  -1.348   1.788  1.00  0.00           H  
HETATM   26  H15 UNL     1       0.908  -0.575   2.085  1.00  0.00           H  
CONECT    1    2   12   13   14
CONECT    2    3    4    5
CONECT    3   15   16   17
CONECT    4   18   19
CONECT    5    6   20   21
CONECT    6    7    7   11
CONECT    7    8   22
CONECT    8    9    9   23
CONECT    9   10   24
CONECT   10   11   11   25
CONECT   11   26
END
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SMILES for HMDB0014337 (Phentermine)

CC(C)(N)CC1=CC=CC=C1
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INCHI for HMDB0014337 (Phentermine)

InChI=1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3
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View in JSmolView Stereo Labels
Synonyms
ValueSource
alpha,alpha-DimethylphenethylamineChEBI
FenterminaChEBI
PhenterminumChEBI
a,a-DimethylphenethylamineGenerator
Α,α-dimethylphenethylamineGenerator
(alpha,alpha)-DimethylphenethylamineHMDB
Adipex pHMDB
Adipex-pHMDB
DuromineHMDB
Hydrochloride, phentermineHMDB
IonamineHMDB
Phentermine hydrochlorideHMDB
AdipexPHMDB
Chemical FormulaC10H15N
Average Molecular Weight149.2328
Monoisotopic Molecular Weight149.120449485
IUPAC Name2-methyl-1-phenylpropan-2-amine
Traditional Namephentermine
CAS Registry Number122-09-8
SMILES
CC(C)(N)CC1=CC=CC=C1
InChI Identifier
InChI=1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3
InChI KeyDHHVAGZRUROJKS-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenethylamines
Direct ParentAmphetamines and derivatives
Alternative Parents
Substituents
  • Amphetamine or derivatives
  • Phenylpropane
  • Aralkylamine
  • Organic nitrogen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Primary amine
  • Organonitrogen compound
  • Primary aliphatic amine
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
ProcessNot Available
Role
Industrial applicationBiological role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point205 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.76 g/LNot Available
LogP2.2Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.76 g/LALOGPS
logP2.32ALOGPS
logP2.08ChemAxon
logS-2.3ALOGPS
pKa (Strongest Basic)10.25ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area26.02 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity48.34 m³·mol⁻¹ChemAxon
Polarizability17.87 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+133.11931661259
DarkChem[M-H]-130.45431661259
DeepCCS[M+H]+136.18430932474
DeepCCS[M-H]-132.88130932474
DeepCCS[M-2H]-170.02830932474
DeepCCS[M+Na]+145.56730932474
AllCCS[M+H]+130.332859911
AllCCS[M+H-H2O]+125.832859911
AllCCS[M+NH4]+134.532859911
AllCCS[M+Na]+135.832859911
AllCCS[M-H]-134.432859911
AllCCS[M+Na-2H]-135.932859911
AllCCS[M+HCOO]-137.632859911

Predicted Retention Times

Underivatized

Chromatographic MethodRetention TimeReference
Measured using a Waters Acquity ultraperformance liquid chromatography (UPLC) ethylene-bridged hybrid (BEH) C18 column (100 mm × 2.1 mm; 1.7 μmparticle diameter). Predicted by Afia on May 17, 2022. Predicted by Afia on May 17, 2022.3.25 minutes32390414
Predicted by Siyang on May 30, 202210.7099 minutes33406817
Predicted by Siyang using ReTip algorithm on June 8, 20225.21 minutes32390414
AjsUoB = Accucore 150 Amide HILIC with 10mM Ammonium Formate, 0.1% Formic Acid43.0 seconds40023050
Fem_Long = Waters ACQUITY UPLC HSS T3 C18 with Water:MeOH and 0.1% Formic Acid1295.6 seconds40023050
Fem_Lipids = Ascentis Express C18 with (60:40 water:ACN):(90:10 IPA:ACN) and 10mM NH4COOH + 0.1% Formic Acid347.1 seconds40023050
Life_Old = Waters ACQUITY UPLC BEH C18 with Water:(20:80 acetone:ACN) and 0.1% Formic Acid131.9 seconds40023050
Life_New = RP Waters ACQUITY UPLC HSS T3 C18 with Water:(30:70 MeOH:ACN) and 0.1% Formic Acid189.4 seconds40023050
RIKEN = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid89.0 seconds40023050
Eawag_XBridgeC18 = XBridge C18 3.5u 2.1x50 mm with Water:MeOH and 0.1% Formic Acid333.3 seconds40023050
BfG_NTS_RP1 =Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) with Water:ACN and 0.1% Formic Acid337.9 seconds40023050
HILIC_BDD_2 = Merck SeQuant ZIC-HILIC with ACN(0.1% formic acid):water(16 mM ammonium formate)145.4 seconds40023050
UniToyama_Atlantis = RP Waters Atlantis T3 (2.1 x 150 mm, 5 um) with ACN:Water and 0.1% Formic Acid891.7 seconds40023050
BDD_C18 = Hypersil Gold 1.9µm C18 with Water:ACN and 0.1% Formic Acid345.6 seconds40023050
UFZ_Phenomenex = Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex with Water:MeOH and 0.1% Formic Acid919.1 seconds40023050
SNU_RIKEN_POS = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid232.1 seconds40023050
RPMMFDA = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid288.7 seconds40023050
MTBLS87 = Merck SeQuant ZIC-pHILIC column with ACN:Water and :ammonium carbonate322.4 seconds40023050
KI_GIAR_zic_HILIC_pH2_7 = Merck SeQuant ZIC-HILIC with ACN:Water and 0.1% FA330.7 seconds40023050
Meister zic-pHILIC pH9.3 = Merck SeQuant ZIC-pHILIC column with ACN:Water 5mM NH4Ac pH9.3 and 5mM ammonium acetate in water10.6 seconds40023050

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
PhentermineCC(C)(N)CC1=CC=CC=C11627.7Standard polar33892256
PhentermineCC(C)(N)CC1=CC=CC=C11165.3Standard non polar33892256
PhentermineCC(C)(N)CC1=CC=CC=C11165.7Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Phentermine,1TMS,isomer #1CC(C)(CC1=CC=CC=C1)N[Si](C)(C)C1373.1Semi standard non polar33892256
Phentermine,1TMS,isomer #1CC(C)(CC1=CC=CC=C1)N[Si](C)(C)C1395.4Standard non polar33892256
Phentermine,1TMS,isomer #1CC(C)(CC1=CC=CC=C1)N[Si](C)(C)C1593.2Standard polar33892256
Phentermine,2TMS,isomer #1CC(C)(CC1=CC=CC=C1)N([Si](C)(C)C)[Si](C)(C)C1589.6Semi standard non polar33892256
Phentermine,2TMS,isomer #1CC(C)(CC1=CC=CC=C1)N([Si](C)(C)C)[Si](C)(C)C1572.8Standard non polar33892256
Phentermine,2TMS,isomer #1CC(C)(CC1=CC=CC=C1)N([Si](C)(C)C)[Si](C)(C)C1668.8Standard polar33892256
Phentermine,1TBDMS,isomer #1CC(C)(CC1=CC=CC=C1)N[Si](C)(C)C(C)(C)C1611.2Semi standard non polar33892256
Phentermine,1TBDMS,isomer #1CC(C)(CC1=CC=CC=C1)N[Si](C)(C)C(C)(C)C1617.8Standard non polar33892256
Phentermine,1TBDMS,isomer #1CC(C)(CC1=CC=CC=C1)N[Si](C)(C)C(C)(C)C1711.6Standard polar33892256
Phentermine,2TBDMS,isomer #1CC(C)(CC1=CC=CC=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2013.8Semi standard non polar33892256
Phentermine,2TBDMS,isomer #1CC(C)(CC1=CC=CC=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C1968.2Standard non polar33892256
Phentermine,2TBDMS,isomer #1CC(C)(CC1=CC=CC=C1)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C1860.6Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Phentermine GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a4l-9000000000-4b4613b00514123920112017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Phentermine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Phentermine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-0a4i-9100000000-7037d3f1fad22de72c332014-09-20Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 80V, Positive-QTOFsplash10-0006-9000000000-1317a1dff976bad4f8402021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 45V, Positive-QTOFsplash10-0006-9100000000-c3cf4661cf2e9753892b2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 30V, Positive-QTOFsplash10-0006-9000000000-798c9f163004230fe7232021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 35V, Positive-QTOFsplash10-00kf-9000000000-356c0f3eb16f8fe213c02021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 30V, Positive-QTOFsplash10-00kf-9000000000-12472f6717ab22723d532021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 15V, Positive-QTOFsplash10-0006-9000000000-d5cc268e81c53c1db6912021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 40V, Positive-QTOFsplash10-0006-9100000000-bfce4f0893d61e18c6422021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 75V, Positive-QTOFsplash10-0006-9000000000-4027bc21c9067b2afaaf2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 65V, Positive-QTOFsplash10-0006-9000000000-78df824f14afb3ef58192021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 40V, Positive-QTOFsplash10-014l-9000000000-162a1d1b79c4d13aa4d02021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 45V, Positive-QTOFsplash10-014l-9000000000-9d917981d06565d9120a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 60V, Positive-QTOFsplash10-014i-9000000000-2ee6ba63f942e329e01b2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 45V, Positive-QTOFsplash10-014l-9000000000-87fec87ba12fab4c26b62021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 70V, Positive-QTOFsplash10-0006-9000000000-6482075e713588714fc72021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 50V, Positive-QTOFsplash10-0006-9000000000-a9d629ba954d37de18942021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 25V, Positive-QTOFsplash10-0006-9000000000-2edf07337f14f6bb795a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 80V, Positive-QTOFsplash10-0006-9000000000-57fedb34031977b99d692021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 20V, Positive-QTOFsplash10-0006-9000000000-40c3cdc442be6ab34e412021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Phentermine 35V, Positive-QTOFsplash10-00dr-9200000000-e6e9a40aadab17c1eb7d2021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phentermine 10V, Positive-QTOFsplash10-0ue9-0900000000-f2eb273dfd0ec45869c52015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phentermine 20V, Positive-QTOFsplash10-0f89-2900000000-f527ee48b9e2784c178c2015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phentermine 40V, Positive-QTOFsplash10-0159-4900000000-548f73a83354267c9f812015-04-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phentermine 10V, Negative-QTOFsplash10-0002-0900000000-c7ab0aa268d14ae3da392015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phentermine 20V, Negative-QTOFsplash10-0002-1900000000-ce1c08c021fbc1cc5c8c2015-04-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Phentermine 40V, Negative-QTOFsplash10-001i-2900000000-94b2b38953d359938c0a2015-04-25Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00191 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00191 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00191
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID4607
KEGG Compound IDC07438
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkPhentermine
METLIN IDNot Available
PubChem Compound4771
PDB IDNot Available
ChEBI ID8080
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Bray GA: A concise review on the therapeutics of obesity. Nutrition. 2000 Oct;16(10):953-60. [PubMed:11054601 ]
  2. Nelson DL, Gehlert DR: Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine. 2006 Feb;29(1):49-60. [PubMed:16622292 ]

Enzymes

Enzyme Details
1. Amine oxidase [flavin-containing] B
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Gene Name:
MAOB
Uniprot ID:
P27338
Molecular weight:
58762.475
References
  1. Rothman RB: Does phentermine inhibit monoamine oxidase? Lancet. 1999 Apr 17;353(9161):1362-3. [PubMed:10218558 ]
  2. Rothman RB: Is phentermine an inhibitor of monoamine oxidase? A critical appraisal. Synapse. 1999 May;32(2):141-5. [PubMed:10231134 ]
  3. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. [PubMed:10799660 ]
  4. Kilpatrick IC, Traut M, Heal DJ: Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine release. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1454-8. [PubMed:11673765 ]
  5. Nandigama RK, Newton-Vinson P, Edmondson DE: Phentermine inhibition of recombinant human liver monoamine oxidases A and B. Biochem Pharmacol. 2002 Mar 1;63(5):865-9. [PubMed:11911838 ]
Enzyme Details
2. Amine oxidase [flavin-containing] A
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
MAOA
Uniprot ID:
P21397
Molecular weight:
59681.27
References
  1. Rothman RB: Is phentermine an inhibitor of monoamine oxidase? A critical appraisal. Synapse. 1999 May;32(2):141-5. [PubMed:10231134 ]
  2. Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. [PubMed:10799660 ]
  3. Kilpatrick IC, Traut M, Heal DJ: Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine release. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1454-8. [PubMed:11673765 ]
  4. Nandigama RK, Newton-Vinson P, Edmondson DE: Phentermine inhibition of recombinant human liver monoamine oxidases A and B. Biochem Pharmacol. 2002 Mar 1;63(5):865-9. [PubMed:11911838 ]
Enzyme Details
3. Cytochrome P450 2C9
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
4. Cytochrome P450 2D6
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular weight:
55768.94
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
5. Cytochrome P450 1A2
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular weight:
58406.915
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
6. Sodium-dependent dopamine transporter
General function:
Involved in neurotransmitter:sodium symporter activity
Specific function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular weight:
68494.255
References
  1. John CE, Jones SR: Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007 Jun;52(8):1596-605. Epub 2007 Mar 16. [PubMed:17459426 ]
  2. Gruner JA, Marcy VR, Lin YG, Bozyczko-Coyne D, Marino MJ, Gasior M: The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep. 2009 Nov;32(11):1425-38. [PubMed:19928382 ]

Transporters

Enzyme Details
1. Sodium-dependent noradrenaline transporter
General function:
Involved in neurotransmitter:sodium symporter activity
Specific function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular weight:
69331.42
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Stephens LC, Katz SG: Phentermine and anaesthesia. Anaesth Intensive Care. 2005 Aug;33(4):525-7. [PubMed:16119498 ]
  4. Samanin R, Garattini S: Neurochemical mechanism of action of anorectic drugs. Pharmacol Toxicol. 1993 Aug;73(2):63-8. [PubMed:7902561 ]
  5. Proietto J, Fam BC, Ainslie DA, Thorburn AW: Novel anti-obesity drugs. Expert Opin Investig Drugs. 2000 Jun;9(6):1317-26. [PubMed:11060745 ]
Enzyme Details
2. Sodium-dependent serotonin transporter
General function:
Involved in neurotransmitter:sodium symporter activity
Specific function:
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Gene Name:
SLC6A4
Uniprot ID:
P31645
Molecular weight:
70324.165
References
  1. John CE, Jones SR: Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007 Jun;52(8):1596-605. Epub 2007 Mar 16. [PubMed:17459426 ]
  2. Johnson GJ, Leis LA, Dunlop PC, Weir EK: The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. J Thromb Haemost. 2003 Dec;1(12):2663-8. [PubMed:14675103 ]
  3. Mekontso-Dessap A, Brouri F, Pascal O, Lechat P, Hanoun N, Lanfumey L, Seif I, Benhaiem-Sigaux N, Kirsch M, Hamon M, Adnot S, Eddahibi S: Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice. Circulation. 2006 Jan 3;113(1):81-9. Epub 2005 Dec 27. [PubMed:16380550 ]
  4. Rothman RB, Ayestas MA, Dersch CM, Baumann MH: Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation. 1999 Aug 24;100(8):869-75. [PubMed:10458725 ]
  5. Zolkowska D, Rothman RB, Baumann MH: Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. J Pharmacol Exp Ther. 2006 Aug;318(2):604-10. Epub 2006 Apr 27. [PubMed:16644904 ]