Hmdb loader

HMDBP00126 (Aldehyde oxidase) Metabolite Associations

Displaying metabolite protein links 1 - 25 of 36 in total
HMDB ID Name CAS NumberStructureFormula Average Mass
Monoisotopic Mass 		References
HMDB0256500PhthalazineThumbC8H6N2130.15
130.053098201		Not Available
HMDB02470536-DeoxypenciclovirThumbC10H15N5O2237.263
237.122574743		Not Available
HMDB0060463Citalopram propionic acidThumbC18H14FNO3311.3071
311.095771524		Not Available
HMDB0060462Citalopram aldehydeThumbC18H14FNO2295.3077
295.100856902		Not Available
HMDB0059597Hydrogen IonThumbH1.0079
1.007825032		Not Available
HMDB0031219Ethyl carbamate51-79-6ThumbC3H7NO289.0932
89.047678473
  1. Sugihara K, Kitamura S, Tatsumi K: Involvement of liver aldehyde oxidase in conversion of N-hydroxyurethane to urethane. J Pharmacobiodyn. 1983 Sep;6(9):677-83. [PubMed:6689178 ]
HMDB0030788Citrusal5980-07-4ThumbC15H16O4260.2851
260.104859		Not Available
HMDB0015097Zaleplon151319-34-5ThumbC17H15N5O305.3339
305.127660127
  1. Obach RS: Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos. 2004 Jan;32(1):89-97. [PubMed:14709625 ]
  2. Lake BG, Ball SE, Kao J, Renwick AB, Price RJ, Scatina JA: Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase. Xenobiotica. 2002 Oct;32(10):835-47. [PubMed:12419014 ]
HMDB0015045Zonisamide68291-97-4ThumbC8H8N2O3S212.226
212.025562822
  1. Sugihara K, Kitamura S, Tatsumi K: Involvement of mammalian liver cytosols and aldehyde oxidase in reductive metabolism of zonisamide. Drug Metab Dispos. 1996 Feb;24(2):199-202. [PubMed:8742231 ]
  2. Kitamura S, Ohashi KNK, Sugihara K, Hosokawa R, Akagawa Y, Ohta S: Extremely high drug-reductase activity based on aldehyde oxidase in monkey liver. Biol Pharm Bull. 2001 Jul;24(7):856-9. [PubMed:11456132 ]
HMDB0014703Methotrexate59-05-2ThumbC20H22N8O5454.4393
454.171315854
  1. Zientek M, Jiang Y, Youdim K, Obach RS: In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010 Aug;38(8):1322-7. doi: 10.1124/dmd.110.033555. Epub 2010 May 5. [PubMed:20444863 ]
  2. Baggott JE, Morgan SL: Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation. Arthritis Rheum. 2009 Aug;60(8):2257-61. doi: 10.1002/art.24685. [PubMed:19644884 ]
  3. Jordan CG, Rashidi MR, Laljee H, Clarke SE, Brown JE, Beedham C: Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man. J Pharm Pharmacol. 1999 Apr;51(4):411-8. [PubMed:10385213 ]
HMDB0014627Brimonidine59803-98-4ThumbC11H10BrN5292.135
291.011957992
  1. Acheampong AA, Chien DS, Lam S, Vekich S, Breau A, Usansky J, Harcourt D, Munk SA, Nguyen H, Garst M, Tang-Liu D: Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase. Xenobiotica. 1996 Oct;26(10):1035-55. [PubMed:8905918 ]
HMDB0014624Raloxifene84449-90-1ThumbC28H27NO4S473.583
473.166079047
  1. Obach RS: Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos. 2004 Jan;32(1):89-97. [PubMed:14709625 ]
  2. Obach RS, Huynh P, Allen MC, Beedham C: Human liver aldehyde oxidase: inhibition by 239 drugs. J Clin Pharmacol. 2004 Jan;44(1):7-19. [PubMed:14681337 ]
  3. Sahi J, Khan KK, Black CB: Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human. Drug Metab Lett. 2008 Aug;2(3):176-83. [PubMed:19356090 ]
HMDB0014581Allopurinol315-30-0ThumbC5H4N4O136.1115
136.03851077
  1. Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. [PubMed:8216357 ]
HMDB0014570Famciclovir104227-87-4ThumbC14H19N5O4321.3318
321.143704121
  1. Rashidi MR, Smith JA, Clarke SE, Beedham C: In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. Drug Metab Dispos. 1997 Jul;25(7):805-13. [PubMed:9224775 ]
  2. Al-Salmy HS: Inter-strain variability in aldehyde oxidase activity in the mouse. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Jul;132(3):341-7. [PubMed:12161167 ]
HMDB0014483Pyrazinamide98-96-4ThumbC5H5N3O123.1127
123.043261797
  1. Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. [PubMed:8216357 ]
HMDB0004194N1-Methyl-4-pyridone-3-carboxamide769-49-3ThumbC7H8N2O2152.1506
152.05857751		Not Available
HMDB0004193Nudifloramide701-44-0ThumbC7H8N2O2152.1506
152.05857751		Not Available
HMDB00040735-Hydroxyindoleacetaldehyde1892-21-3ThumbC10H9NO2175.184
175.063328537		Not Available
HMDB0004062Gentisate aldehyde1194-98-5ThumbC7H6O3138.1207
138.031694058		Not Available
HMDB0003178Heme14875-96-8ThumbC34H32FeN4O4616.487
616.177297665		Not Available
HMDB0003125Hydrogen peroxide7722-84-1ThumbH2O234.0147
34.005479308		Not Available
HMDB0002217(S)-Methylmalonic acid semialdehyde99043-16-0ThumbC4H6O3102.0886
102.031694058		Not Available
HMDB0002111Water7732-18-5ThumbH2O18.0153
18.010564686		Not Available
HMDB0001892Menadione58-27-5ThumbC11H8O2172.18
172.0524295
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
HMDB0001545Pyridoxal66-72-8ThumbC8H9NO3167.162
167.058243159		Not Available
Displaying metabolite protein links 1 - 25 of 36 in total