| HMDB0015045 | Zonisamide | 68291-97-4 |  | C8H8N2O3S | 212.226
212.025562822 | - Sugihara K, Kitamura S, Tatsumi K: Involvement of mammalian liver cytosols and aldehyde oxidase in reductive metabolism of zonisamide. Drug Metab Dispos. 1996 Feb;24(2):199-202. [PubMed:8742231 ]
- Kitamura S, Ohashi KNK, Sugihara K, Hosokawa R, Akagawa Y, Ohta S: Extremely high drug-reductase activity based on aldehyde oxidase in monkey liver. Biol Pharm Bull. 2001 Jul;24(7):856-9. [PubMed:11456132 ]
|
| HMDB0015097 | Zaleplon | 151319-34-5 |  | C17H15N5O | 305.3339
305.127660127 | - Obach RS: Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos. 2004 Jan;32(1):89-97. [PubMed:14709625 ]
- Lake BG, Ball SE, Kao J, Renwick AB, Price RJ, Scatina JA: Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase. Xenobiotica. 2002 Oct;32(10):835-47. [PubMed:12419014 ]
|
| HMDB0002111 | Water | 7732-18-5 |  | H2O | 18.0153
18.010564686 | Not Available |
| HMDB0014624 | Raloxifene | 84449-90-1 |  | C28H27NO4S | 473.583
473.166079047 | - Obach RS: Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos. 2004 Jan;32(1):89-97. [PubMed:14709625 ]
- Obach RS, Huynh P, Allen MC, Beedham C: Human liver aldehyde oxidase: inhibition by 239 drugs. J Clin Pharmacol. 2004 Jan;44(1):7-19. [PubMed:14681337 ]
- Sahi J, Khan KK, Black CB: Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human. Drug Metab Lett. 2008 Aug;2(3):176-83. [PubMed:19356090 ]
|
| HMDB0001545 | Pyridoxal | 66-72-8 |  | C8H9NO3 | 167.162
167.058243159 | Not Available |
| HMDB0014483 | Pyrazinamide | 98-96-4 |  | C5H5N3O | 123.1127
123.043261797 | - Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. [PubMed:8216357 ]
|
| HMDB0256500 | Phthalazine | |  | C8H6N2 | 130.15
130.053098201 | Not Available |
| HMDB0001377 | Oxygen | 7782-44-7 |  | O2 | 31.9988
31.989829244 | Not Available |
| HMDB0004193 | Nudifloramide | 701-44-0 |  | C7H8N2O2 | 152.1506
152.05857751 | Not Available |
| HMDB0004194 | N1-Methyl-4-pyridone-3-carboxamide | 769-49-3 |  | C7H8N2O2 | 152.1506
152.05857751 | Not Available |
| HMDB0001302 | Molybdenum | 7439-98-7 |  | Mo | 95.94
97.905407846 | Not Available |
| HMDB0000202 | Methylmalonic acid | 516-05-2 |  | C4H6O4 | 118.088
118.02660868 | Not Available |
| HMDB0014703 | Methotrexate | 59-05-2 |  | C20H22N8O5 | 454.4393
454.171315854 | - Zientek M, Jiang Y, Youdim K, Obach RS: In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010 Aug;38(8):1322-7. doi: 10.1124/dmd.110.033555. Epub 2010 May 5. [PubMed:20444863 ]
- Baggott JE, Morgan SL: Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation. Arthritis Rheum. 2009 Aug;60(8):2257-61. doi: 10.1002/art.24685. [PubMed:19644884 ]
- Jordan CG, Rashidi MR, Laljee H, Clarke SE, Brown JE, Beedham C: Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man. J Pharm Pharmacol. 1999 Apr;51(4):411-8. [PubMed:10385213 ]
|
| HMDB0001892 | Menadione | 58-27-5 |  | C11H8O2 | 172.18
172.0524295 | - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
|
| HMDB0003125 | Hydrogen peroxide | 7722-84-1 |  | H2O2 | 34.0147
34.005479308 | Not Available |
| HMDB0059597 | Hydrogen Ion | |  | H | 1.0079
1.007825032 | Not Available |
| HMDB0003178 | Heme | 14875-96-8 |  | C34H32FeN4O4 | 616.487
616.177297665 | Not Available |
| HMDB0000152 | Gentisic acid | 490-79-9 |  | C7H6O4 | 154.121
154.026608673 | Not Available |
| HMDB0004062 | Gentisate aldehyde | 1194-98-5 |  | C7H6O3 | 138.1207
138.031694058 | Not Available |
| HMDB0014570 | Famciclovir | 104227-87-4 |  | C14H19N5O4 | 321.3318
321.143704121 | - Rashidi MR, Smith JA, Clarke SE, Beedham C: In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. Drug Metab Dispos. 1997 Jul;25(7):805-13. [PubMed:9224775 ]
- Al-Salmy HS: Inter-strain variability in aldehyde oxidase activity in the mouse. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Jul;132(3):341-7. [PubMed:12161167 ]
|
| HMDB0001248 | FAD | 146-14-5 |  | C27H33N9O15P2 | 785.5497
785.157134455 | Not Available |
| HMDB0031219 | Ethyl carbamate | 51-79-6 |  | C3H7NO2 | 89.0932
89.047678473 | - Sugihara K, Kitamura S, Tatsumi K: Involvement of liver aldehyde oxidase in conversion of N-hydroxyurethane to urethane. J Pharmacobiodyn. 1983 Sep;6(9):677-83. [PubMed:6689178 ]
|
| HMDB0001046 | Cotinine | 486-56-6 |  | C10H12N2O | 176.2151
176.094963016 | Not Available |
| HMDB0030788 | Citrusal | 5980-07-4 |  | C15H16O4 | 260.2851
260.104859 | Not Available |
| HMDB0060463 | Citalopram propionic acid | |  | C18H14FNO3 | 311.3071
311.095771524 | Not Available |
