Hmdb loader

HMDBP00636 (cAMP-specific 3',5'-cyclic phosphodiesterase 4D) Metabolite Associations

Displaying metabolite protein links 1 - 25 of 7127 in total
HMDB ID Name CAS NumberStructureFormula Average Mass
Monoisotopic Mass 		References
HMDB0000045Adenosine monophosphate61-19-8ThumbC10H14N5O7P347.2212
347.063084339		Not Available
HMDB0000058Cyclic AMP60-92-4ThumbC10H12N5O6P329.2059
329.052519653		Not Available
HMDB0001314Cyclic GMP7665-99-8ThumbC10H12N5O7P345.2053
345.047434275		Not Available
HMDB0014789Dyphylline479-18-5ThumbC10H14N4O4254.2426
254.101504956
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Hariton C: Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 2;258(1-2):85-94. [PubMed:7925603 ]
HMDB0001397Guanosine monophosphate85-32-5ThumbC10H14N5O8P363.2206
363.057998961		Not Available
HMDB0015614Ibudilast50847-11-5ThumbC14H18N2O230.3055
230.141913208
  1. Huang Z, Liu S, Zhang L, Salem M, Greig GM, Chan CC, Natsumeda Y, Noguchi K: Preferential inhibition of human phosphodiesterase 4 by ibudilast. Life Sci. 2006 May 1;78(23):2663-8. Epub 2005 Nov 28. [PubMed:16313925 ]
HMDB0015220Iloprost78919-13-8ThumbC30H38O5478.6197
478.271924326
  1. Wilkens H, Guth A, Konig J, Forestier N, Cremers B, Hennen B, Bohm M, Sybrecht GW: Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation. 2001 Sep 11;104(11):1218-22. [PubMed:11551870 ]
  2. Ghofrani HA, Rose F, Schermuly RT, Olschewski H, Wiedemann R, Weissmann N, Schudt C, Tenor H, Seeger W, Grimminger F: Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension. Crit Care Med. 2002 Nov;30(11):2489-92. [PubMed:12441759 ]
  3. Schermuly RT, Leuchte H, Ghofrani HA, Weissmann N, Rose F, Kohstall M, Olschewski H, Schudt C, Grimminger F, Seeger W, Walmrath D: Zardaverine and aerosolised iloprost in a model of acute respiratory failure. Eur Respir J. 2003 Aug;22(2):342-7. [PubMed:12952271 ]
  4. Grant PG, Mannarino AF, Colman RW: cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity. Proc Natl Acad Sci U S A. 1988 Dec;85(23):9071-5. [PubMed:2461561 ]
HMDB0015056Ketotifen34580-14-8ThumbC19H19NOS309.425
309.118734925
  1. Castillo JG, Gamboa PM, Garcia BE, Oehling A: Effect of ketotifen on phosphodiesterase activity from asthmatic individuals. Allergol Immunopathol (Madr). 1990 Jul-Aug;18(4):197-201. [PubMed:1702263 ]
  2. Huang Z, Liu S, Zhang L, Salem M, Greig GM, Chan CC, Natsumeda Y, Noguchi K: Preferential inhibition of human phosphodiesterase 4 by ibudilast. Life Sci. 2006 May 1;78(23):2663-8. Epub 2005 Nov 28. [PubMed:16313925 ]
HMDB0000547Magnesium7439-95-4ThumbMg24.305
23.985041898		Not Available
HMDB0001333Manganese7439-96-5ThumbMn54.938
54.938049636		Not Available
HMDB0114773PA(10:0/13:0)ThumbC26H51O8P522.66
522.3321556		Not Available
HMDB0114774PA(10:0/17:0)ThumbC30H59O8P578.768
578.394755858		Not Available
HMDB0262697PA(10:0/18:1(12Z)-2OH(9,10))ThumbC31H59O10P622.777
622.384585098		Not Available
HMDB0262699PA(10:0/18:1(12Z)-O(9S,10R))ThumbC31H57O9P604.762
604.374020413		Not Available
HMDB0262701PA(10:0/18:1(9Z)-O(12,13))ThumbC31H57O9P604.762
604.374020413		Not Available
HMDB0262693PA(10:0/18:2(10E,12Z)+=O(9))ThumbC31H55O9P602.746
602.358370349		Not Available
HMDB0262695PA(10:0/18:2(9Z,11E)+=O(13))ThumbC31H55O9P602.746
602.358370349		Not Available
HMDB0262731PA(10:0/18:3(10,12,15)-OH(9))ThumbC31H55O9P602.746
602.358370349		Not Available
HMDB0262733PA(10:0/18:3(9,11,15)-OH(13))ThumbC31H55O9P602.746
602.358370349		Not Available
HMDB0114775PA(10:0/19:0)ThumbC32H63O8P606.822
606.426055987		Not Available
HMDB0262643PA(10:0/20:3(5Z,11Z,14Z)-O(8,9))ThumbC33H57O9P628.784
628.374020413		Not Available
HMDB0262639PA(10:0/20:3(5Z,8Z,11Z)-O(14R,15S))ThumbC33H57O9P628.784
628.374020413		Not Available
HMDB0262641PA(10:0/20:3(5Z,8Z,14Z)-O(11S,12R))ThumbC33H57O9P628.784
628.374020413		Not Available
HMDB0262741PA(10:0/20:3(6,8,11)-OH(5))ThumbC33H59O9P630.8
630.389670478		Not Available
HMDB0262685PA(10:0/20:3(8Z,11Z,14Z)-2OH(5,6))ThumbC33H59O10P646.799
646.384585098		Not Available
Displaying metabolite protein links 1 - 25 of 7127 in total