Hmdb loader
Identification
HMDB Protein ID HMDBP01081
Secondary Accession Numbers
  • 6370
Name Poly(A) polymerase gamma
Synonyms
  1. Neo-PAP
  2. Neo-poly(A) polymerase
  3. PAP-gamma
  4. Polynucleotide adenylyltransferase gamma
  5. SRP RNA 3'-adenylating enzyme
Gene Name PAPOLG
Protein Type Enzyme
Biological Properties
General Function Involved in nucleotidyltransferase activity
Specific Function Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.
Pathways
  • mRNA surveillance pathway
Reactions
Adenosine triphosphate + RNA(n) → Pyrophosphate + RNA(n+1) details
GO Classification
Biological Process
mRNA polyadenylation
transcription, DNA-dependent
Cellular Component
nucleus
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
catalytic activity
polynucleotide adenylyltransferase activity
adenylyltransferase activity
nucleotidyltransferase activity
rna binding
transferase activity, transferring phosphorus-containing groups
binding
transferase activity
nucleic acid binding
Molecular Function
metal ion binding
ATP binding
RNA binding
polynucleotide adenylyltransferase activity
Process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
biosynthetic process
rna processing
transcription
cellular macromolecule metabolic process
rna polyadenylation
rna 3'-end processing
rna metabolic process
metabolic process
macromolecule metabolic process
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location 2
Locus 2p16.1
SNPs PAPOLG
Gene Sequence
>2211 bp
ATGAAAGAGATGTCTGCAAACACCGTGCTGGACAGCCAGCGTCAACAAAAGCATTATGGA
ATTACCTCCCCAATTAGTTTGGCATCTCCTAAAGAAATTGATCATATTTACACACAGAAA
TTAATTGACGCCATGAAACCATTTGGAGTGTTTGAAGATGAGGAAGAATTGAACCACAGG
CTGGTGGTTCTTGGTAAATTGAACAATTTAGTAAAAGAATGGATTTCTGATGTCAGCGAG
AGTAAGAACCTCCCACCTTCTGTTGTGGCTACTGTTGGTGGTAAAATTTTCACATTTGGA
TCCTATAGGCTTGGAGTACACACCAAAGGAGCTGACATTGATGCACTTTGTGTAGCTCCA
AGACATGTGGAAAGATCTGATTTTTTTCAGTCTTTTTTTGAAAAATTGAAACATCAAGAT
GGCATTAGAAACTTAAGAGCTGTAGAAGATGCCTTTGTACCTGTTATAAAATTTGAATTT
GATGGTATTGAAATTGATCTAGTCTTTGCAAGACTGGCAATACAAACCATATCAGATAAT
TTAGATCTAAGAGACGACTCTCGCCTGAGAAGCCTTGATATAAGGTGTATTCGCAGCTTA
AATGGTTGTAGAGTTACTGATGAAATTTTGCATTTAGTGCCAAATAAAGAAACTTTTAGA
CTCACCCTAAGAGCTGTCAAATTATGGGCAAAACGACGTGGTATTTATTCCAACATGCTA
GGATTCCTTGGTGGTGTCTCCTGGGCAATGCTAGTTGCAAGAACTTGCCAATTGTATCCA
AATGCAGCAGCATCTACTTTAGTTCATAAGTTCTTTTTAGTTTTTTCCAAGTGGGAATGG
CCAAATCCTGTGCTGCTGAAGCAACCAGAAGAAAGCAATTTGAATTTGCCTGTCTGGGAT
CCTCGGGTAAATCCATCAGATAGGTATCATCTCATGCCCATAATCACCCCTGCCTACCCA
CAACAGAATTCTACGTATAATGTGTCCACATCAACTCGAACAGTAATGGTAGAAGAATTT
AAACAAGGTCTTGCAGTCACAGATGAAATTCTTCAAGGAAAGTCAGATTGGTCCAAACTA
CTTGAGCCACCGAATTTCTTTCAAAAGTATAGACATTATATAGTATTGACTGCCAGCGCA
TCAACAGAAGAAAACCATCTAGAGTGGGTTGGATTAGTAGAATCTAAAATCCGTGTACTT
GTTGGAAACTTGGAACGGAATGAATTTATTACTCTTGCCCATGTGAATCCCCAGTCATTC
CCAGGGAATAAGGAACATCATAAAGACAACAATTACGTATCAATGTGGTTCCTTGGGATA
ATTTTTCGGAGAGTAGAAAATGCAGAAAGTGTCAACATAGACTTGACATATGATATACAG
TCATTTACTGATACAGTGTACAGACAGGCAAACAATATAAATATGCTAAAGGAGGGAATG
AAAATTGAAGCAACTCATGTAAAGAAAAAACAACTTCACCACTACCTTCCTGCAGAAATT
CTTCAAAAGAAGAAAAAGCAAAGTCTCTCTGATGTCAATCGAAGCTCGGGCGGACTTCAA
TCCAAAAGATTGTCTCTGGATAGCAGTTGTCTGGATAGCTCCAGAGACACTGATAATGGA
ACACCTTTTAATTCTCCAGCGTCCAAGTCTGATAGCCCTTCTGTAGGAGAAACAGAAAGG
AATAGTGCTGAGCCTGCTGCTGTAATTGTGGAGAAGCCACTGAGTGTACCACCAGCCCAA
GGACTTTCCATTCCAGTGATTGGCGCAAAAGTTGACTCTACAGTAAAAACTGTATCACCC
CCCACTGTGTGTACCATTCCTACCGTAGTAGGACGAAATGTCATTCCTAGAATCACAACA
CCTCACAACCCTGCCCAGGGACAACCGCATCTGAATGGAATGTCAAATATAACTAAGACT
GTTACACCTAAGAGATCCCATTCCCCATCCATAGATGGGACTCCTAAGAGGTTGAAAGAC
GTAGAAAAGTTTATTCGACTTGAATCAACATTTAAGGACCCCCGCACTGCTGAAGAAAGA
AAAAGAAAATCAGTGGATGCCATTGGAGGAGAATCTATGCCTATTCCAACTATTGATACA
TCACGCAAAAAGAGACTACCCAGTAAAGAACTACCAGATTCATCATCTCCAGTTCCAGCA
AACAACATCCGTGTCATCAAAAATTCCATTCGACTGACCCTTAATCGGTAA
Protein Properties
Number of Residues 736
Molecular Weight 82801.935
Theoretical pI 9.149
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Poly(A) polymerase gamma
MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN
LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
NNIRVIKNSIRLTLNR
GenBank ID Protein 15080911
UniProtKB/Swiss-Prot ID Q9BWT3
UniProtKB/Swiss-Prot Entry Name PAPOG_HUMAN
PDB IDs Not Available
GenBank Gene ID AF312211
GeneCard ID PAPOLG
GenAtlas ID PAPOLG
HGNC ID HGNC:14982
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP: Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9. [PubMed:15302935 ]
  6. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  7. Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51. doi: 10.1021/pr0705441. Epub 2008 Jan 26. [PubMed:18220336 ]
  8. Perumal K, Sinha K, Henning D, Reddy R: Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme. J Biol Chem. 2001 Jun 15;276(24):21791-6. Epub 2001 Apr 3. [PubMed:11287430 ]
  9. Topalian SL, Kaneko S, Gonzales MI, Bond GL, Ward Y, Manley JL: Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors. Mol Cell Biol. 2001 Aug;21(16):5614-23. [PubMed:11463842 ]