Human Metabolome Database: Showing Protein Monocarboxylate transporter 6 (HMDBP01113)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP01113

Secondary Accession Numbers

6406

Name

Monocarboxylate transporter 6

Synonyms

MCT 5
MCT 6
Monocarboxylate transporter 5
Solute carrier family 16 member 5

Gene Name

SLC16A5

Protein Type

Enzyme

Biological Properties

General Function

Involved in transmembrane transport

Specific Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane part
cell part
intrinsic to membrane
integral to membrane
Function
transporter activity
secondary active monocarboxylate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
organic acid transmembrane transporter activity
carboxylic acid transmembrane transporter activity
Process
transmembrane transport
organic anion transport
anion transport
ion transport
transport
establishment of localization

Cellular Location

Cell membrane
Multi-pass membrane protein

Gene Properties

Chromosome Location

Chromosome:1

Locus

17q25.1

SNPs

SLC16A5

Gene Sequence

>1518 bp
ATGCCCCAGGCCCTGGAGCGTGCAGATGGCAGCTGGGCCTGGGTGGTGCTGCTGGCCACC
ATGGTGACCCAGGGCCTCACCCTGGGCTTCCCCACGTGTATCGGCATCTTCTTCACTGAA
CTGCAATGGGAGTTCCAGGCCAGCAACAGCGAGACCTCTTGGTTCCCCTCCATCCTCACG
GCTGTGCTCCACATGGCAGGGCCCCTGTGCAGCATCCTGGTGGGACGCTTCGGCTGCCGA
GTGACCGTGATGCTGGGGGGCGTGCTGGCCAGCCTGGGCATGGTGGCCAGCTCCTTCTCT
CACAACCTCAGCCAGCTCTACTTCACAGCAGGATTCATCACAGGCCTGGGCATGTGCTTC
AGCTTCCAGTCAAGCATCACGGTGCTGGGCTTCTACTTTGTCCGCCGGCGGGTGCTGGCC
AACGCGCTGGCCTCGATGGGCGTCTCCCTGGGCATCACCCTCTGGCCGCTGCTCTCCCGT
TACCTTCTGGAGAACCTGGGCTGGAGGGGTACCTTCCTTGTCTTCGGCGGGATCTTTCTC
CACTGCTGCATCTGCGGGGCCATCATAAGGCCTGTGGCCACCAGTGTGGCCCCTGAGACC
AAAGAATGTCCCCCGCCACCTCCCGAGACACCTGCACTTGGCTGCCTGGCTGCATGCGGC
CGGACCATCCAGCGCCACCTGGCCTTCGACATCCTGCGGCACAACACAGGCTACTGCGTG
TACATACTGGGTGTGATGTGGTCCGTCCTGGGCTTCCCACTGCCACAAGTCTTCCTGGTG
CCATATGCCATGTGGCACAGCGTGGACGAGCAGCAGGCAGCCCTCCTCATCTCCATCATC
GGCTTCAGCAACATCTTCCTGAGGCCCCTAGCCGGGCTGATGGCAGGACGGCCGGCCTTT
GCTAGCCACCGCAAGTACCTGTTCAGCCTGGCACTCCTGCTCAATGGGCTCACTAACCTG
GTGTGTGCGGCATCAGGTGACTTCTGGGTGCTCGTGGGCTACTGCCTGGCGTACAGCGTG
TCCATGAGTGGCATCGGCGCCCTCATCTTCCAGGTTCTCATGGACATCGTCCCCATGGAT
CAGTTCCCCAGAGCCCTGGGACTCTTCACTGTCCTGGACGGCCTTGCTTTCCTCATCTCC
CCACCACTGGCCGGGTTGCTCCTGGACGCCACCAACAACTTTAGCTATGTTTTCTACATG
TCCAGCTTCTTCCTCATCTCAGCTGCCCTCTTCATGGGTGGCAGCTTCTACGCCCTGCAG
AAGAAGGAGCAAGGCAAGCAGGCTGTCGCGGCGGATGCCCTGGAGCGGGATCTTTTCTTG
GAAGCCAAAGACGGTCCTGGGAAGCAACGGTCCCCTGAGATCATGTGCCAGTCTTCCCGC
CAGCCACGTCCAGCTGGCGTCAATAAGCATCTTTGGGGATGTCCTGCCTCCTCCAGGACC
AGCCATGAGTGGCTCTTATGGCCAAAGGCGGTACTGCAGGCCAAGCAAACGGCTCTGGGC
TGGAATAGCCCTACCTGA

Protein Properties

Number of Residues

505

Molecular Weight

54993.0

Theoretical pI

8.28

Pfam Domain Function

MFS_1 (PF07690 )

Signals

None

Transmembrane Regions

18-38
54-74
81-101
111-131
138-158
172-192
240-260
275-295
306-326
330-350
368-388
397-417

Protein Sequence

>Monocarboxylate transporter 6
MPQALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILT
AVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCF
SFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFL
HCCICGAIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCV
YILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAF
ASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMD
QFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQ
KKEQGKQAVAADALERDLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWGCPASSRT
SHEWLLWPKAVLQAKQTALGWNSPT

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

O15375

UniProtKB/Swiss-Prot Entry Name

MOT6_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Price NT, Jackson VN, Halestrap AP: Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J. 1998 Jan 15;329 ( Pt 2):321-8. [PubMed:9425115 ]