Human Metabolome Database: Showing Protein Anoctamin-2 (HMDBP07440)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification
HMDB Protein ID	HMDBP07440
Secondary Accession Numbers	13148
Name	Anoctamin-2
Synonyms	Transmembrane protein 16B
Gene Name	ANO2
Protein Type	Unknown
Biological Properties
General Function	Involved in intracellular calcium activated chloride ch
Specific Function	Acts as a calcium-activated chloride channel (CaCC), mostly in photoreceptors. May mediate olfactory amplification in olfactory sensory neurons (OSNs) and light perception amplification in retina
Pathways	Not Available
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Cell membrane Multi-pass membrane protein
Gene Properties
Chromosome Location	Chromosome:1
Locus	12p13.3
SNPs	ANO2
Gene Sequence	>3012 bp ATGGCGACTCCCGGGCCGCGCGATATACCCCTGCTCCCTGGCTCCCCACGCCGGCTGAGC CCTCAGGCAGGGTCCAGAGGGGGCCAGGGCCCCAAACATGGACAGCAGTGTCTCAAGATG CCAGGTCCCCGGGCCCCAGGTCTGCAGGGCGGTTCCAACAGAGATCCTGGCCAGCCCTGC GGTGGAGAGAGCACCCGCAGCAGCTCTGTCATCAACAACTATCTGGATGCCAATGAGCCT GTGTCCTTGGAGGCCCGTCTTAGCCGCATGCACTTCCATGACAGTCAGAGGAAGGTCGAC TATGTACTTGCCTACCACTACCGGAAACGCGGGGTGCACCTGGCCCAAGGCTTCCCTGGC CACTCGCTGGCTATCGTCTCCAATGGGGAGACAGGCAAGGAGCCTCATGCTGGGGGCCCA GGTGACATTGAGCTGGGACCGCTCGATGCCCTGGAGGAGGAGAGGAAGGAGCAGCGGGAG GAATTTGAGCACAATCTGATGGAGGCTGGACTGGAGCTTGAGAAGGACTTGGAGAATAAA AGCCAGGGATCCATCTTTGTCCGGATACACGCCCCGTGGCAGGTGCTGGCCAGAGAGGCA GAATTCTTGAAGATCAAAGTTCCTACCAAGAAAGAGATGTACGAGATCAAAGCAGGAGGC AGCATTGCAAAGAAGTTCAGCGCGGCTCTGCAGAAGCTGAGCTCGCACCTGCAGCCCCGA GTTCCAGAACACAGCAACAACAAGATGAAAAACCTCTCCTACCCATTCTCCAGGGAGAAG ATGTACCTGTACAACATCCAGGAAAAGGACACCTTCTTTGATAATGCCACCCGTAGCCGC ATTGTGCACGAGATCCTGAAGCGCACAGCCTGCTCCCGAGCCAACAACACGATGGGTATT AACTCTCTGATCGCAAACAATATCTATGAGGCTGCCTACCCTCTTCATGACGGTGAATAC GATAGTCCAGAGGACGATATGAATGACAGGAAGCTGCTATATCAAGAATGGGCGCGCTAT GGAGTGTTCTATAAGTTCCAACCTATTGACCTCATCAGAAAGTATTTTGGAGAAAAAATT GGACTGTATTTTGCCTGGCTGGGATTATATACATCATTCCTCATCCCATCTTCTGTAATT GGAGTGATTGTGTTTCTTTATGGATGTGCAACAATTGAAGAAGATATTCCCAGCAGAGAG ATGTGTGACCAGCAGAATGCCTTCACCATGTGTCCCCTGTGTGACAAGTCCTGTGATTAC TGGAACCTCAGCTCAGCCTGTGGGACCGCGCAGGCCAGCCACCTGTTTGACAACCCTGCC ACCGTCTTCTTCTCTATCTTCATGGCTCTGTGGGCTACCATGTTCCTGGAAAACTGGAAG AGGCTACAGATGCGACTGGGCTACTTTTGGGACCTGACTGGCATAGAAGAGGAAGAAGAA CGTGCCCAGGAACATTCCAGGCCTGAGTATGAAACCAAAGTTCGAGAGAAAATGCTAAAG GAGAGCAACCAGTCTGCTGTCCAGAAATTGGAAACAAACACGACGGAGTGTGGCGATGAG GATGATGAAGATAAACTGACCTGGAAGGATCGTTTCCCAGGTTACCTGATGAACTTTGCC TCCATCTTATTCATGATTGCCCTGACATTCTCAATCGTCTTTGGGGTGATAGTGTATCGA ATAACAACTGCAGCCGCTCTGTCTCTCAATAAGGCTACACGCTCCAATGTCCGGGTGACA GTGACAGCAACAGCAGTCATCATCAACCTCGTGGTCATCCTCATCCTGGACGAGATCTAC GGCGCTGTGGCCAAGTGGCTCACCAAAATTGAGGTTCCGAAAACAGAACAGACTTTTGAA GAGCGCCTGATCCTCAAAGCTTTCTTGCTCAAGTTTGTCAATGCCTACTCCCCCATCTTC TATGTGGCCTTTTTCAAAGGGAGGTTTGTGGGCAGGCCTGGAAGCTACGTCTATGTATTC GATGGTTACCGCATGGAAGAGTGTGCTCCAGGGGGCTGTCTCATGGAGCTCTGCATTCAG CTCAGCATCATCATGTTGGGGAAGCAGTTGATCCAGAACAACATCTTTGAGATTGGAGTC CCGAAGCTAAAGAAACTATTTCGAAAGCTGAAAGATGAGACCGAAGCTGGAGAAACTGAC TCTGCCCATTCGAAACATCCAGAGCAGTGGGACCTAGACTACAGCTTGGAACCATACACA GGACTGACTCCGGAGTACATGGAAATGATCATCCAGTTTGGTTTTGTCACCCTCTTCGTG GCCTCCTTTCCCCTGGCACCTGTGTTTGCCCTCCTCAACAACGTCATTGAAGTGCGGCTC GATGCAAAGAAGTTTGTTACAGAGCTGAGACGGCCGGATGCTGTAAGAACCAAAGATATC GGAATCTGGTTTGACATTCTCTCTGGAATTGGCAAGTTCTCTGTTATCAGCAACGCTTTT GTCATTGCGATCACCTCCGACTTTATCCCCCGCCTGGTGTACCAGTACTCCTACAGTCAC AATGGGACTCTGCACGGCTTTGTCAACCACACCCTCTCCTTTTTCAACGTCAGCCAGCTG AAGGAGGGGACGCAGCCAGAAAACTCACAGTTTGACCAGGAGGTTCAGTTCTGCAGGTTT AAGGATTACCGAGAGCCGCCATGGGCCCCGAACCCTTATGAGTTTTCGAAACAGTACTGG TTTATTCTGTCTGCCCGTCTGGCTTTTGTCATAATCTTCCAGAACCTCGTGATGTTCCTG AGCGTCCTCGTGGACTGGATGATTCCAGACATCCCCACGGACATCAGCGACCAGATCAAG AAAGAGAAGAGCTTATTAGTGGATTTCTTCCTGAAAGAGGAGCATGAGAAGCTCAAGCTG ATGGATGAGCCGGCTCTGAGGAGCCCAGGAGGTGGGGATCGAAGCAGGAGCCGGGCAGCC AGCTCAGCACCTTCAGGCCAAAGCCAGCTGGGCAGCATGATGTCGTCAGGCTCTCAGCAC ACCAATGTGTGA
Protein Properties
Number of Residues	1003
Molecular Weight	113968.4
Theoretical pI	6.52
Pfam Domain Function	DUF590 (PF04547 )
Signals	None
Transmembrane Regions	366-386 435-455 539-559 583-603 624-644 749-769 802-822 908-928
Protein Sequence	>Anoctamin-2 MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPC GGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPG HSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENK SQGSIFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPR VPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGI NSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKI GLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDY WNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEE RAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFA SILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIY GAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVF DGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETD SAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRL DAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSH NGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYW FILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKL MDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV
External Links
GenBank ID Protein	219809115
UniProtKB/Swiss-Prot ID	Q9NQ90
UniProtKB/Swiss-Prot Entry Name	ANO2_HUMAN
PDB IDs	Not Available
GenBank Gene ID	FJ384095
GeneCard ID	ANO2
GenAtlas ID	ANO2
HGNC ID	HGNC:1183
References
General References	Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ] Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U: TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature. 2008 Oct 30;455(7217):1210-5. doi: 10.1038/nature07313. Epub 2008 Aug 24. [PubMed:18724360 ] Stohr H, Heisig JB, Benz PM, Schoberl S, Milenkovic VM, Strauss O, Aartsen WM, Wijnholds J, Weber BH, Schulz HL: TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci. 2009 May 27;29(21):6809-18. doi: 10.1523/JNEUROSCI.5546-08.2009. [PubMed:19474308 ]