Hmdb loader

Showing Protein Gamma-synuclein (HMDBP08037)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP08037
Secondary Accession Numbers
  • 13748
Name Gamma-synuclein
Synonyms
  1. Breast cancer-specific gene 1 protein
  2. Persyn
  3. SR
  4. Synoretin
Gene Name SNCG
Protein Type Unknown
Biological Properties
General Function Involved in protein binding
Specific Function Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular part
cytoplasm
Cellular Location
  1. Cytoplasm
  2. Cytoplasm
  3. Cytoplasm
  4. perinuclear region
  5. cytoskeleton
  6. cytoskeleton
  7. spindle
  8. centrosome
Gene Properties
Chromosome Location Chromosome:1
Locus 10q23.2-q23.3
SNPs SNCG
Gene Sequence 
>384 bp
ATGGATGTTTTCAAGAAGGGCTTCTCCATCGCCAAGAAGGGCGTGGTGGGTGCGGTGGAA
AAGACCAAGCAGGGGGTGACGGAAGCAGCTGAGAAGACCAAGGAGGGGGTCATGTATGTG
GGAGCCAAGACCAAGGAGAATGTTGTACAGAGCGTGACCTCAGTGGCCGAGAAGACCAAG
GAGCAGGCCAACGCCGTGAGCAAGGCTGTGGTGAGCAGCGTCAACACTGTGGCCACCAAG
ACCGTGGAGGAGGCGGAGAACATCGCGGTCACCTCCGGGGTGGTGCGCAAGGAGGACTTG
AGGCCATCTGCCCCCCAACAGGAGGGTGAGGCATCCAAAGAGAAAGAGGAAGTGGCAGAG
GAGGCCCAGAGTGGGGGAGACTAG
Protein Properties
Number of Residues 127
Molecular Weight 13330.8
Theoretical pI 4.54
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Gamma-synuclein
MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK
EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE
EAQSGGD
GenBank ID Protein 2281474
UniProtKB/Swiss-Prot ID O76070
UniProtKB/Swiss-Prot Entry Name SYUG_HUMAN
PDB IDs Not Available
GenBank Gene ID AF010126
GeneCard ID SNCG
GenAtlas ID SNCG
HGNC ID HGNC:11141
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  3. Pronin AN, Morris AJ, Surguchov A, Benovic JL: Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem. 2000 Aug 25;275(34):26515-22. [PubMed:10852916 ]
  4. Ji H, Liu YE, Jia T, Wang M, Liu J, Xiao G, Joseph BK, Rosen C, Shi YE: Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res. 1997 Feb 15;57(4):759-64. [PubMed:9044857 ]
  5. Ninkina NN, Alimova-Kost MV, Paterson JW, Delaney L, Cohen BB, Imreh S, Gnuchev NV, Davies AM, Buchman VL: Organization, expression and polymorphism of the human persyn gene. Hum Mol Genet. 1998 Sep;7(9):1417-24. [PubMed:9700196 ]
  6. Lavedan C, Leroy E, Dehejia A, Buchholtz S, Dutra A, Nussbaum RL, Polymeropoulos MH: Identification, localization and characterization of the human gamma-synuclein gene. Hum Genet. 1998 Jul;103(1):106-12. [PubMed:9737786 ]
  7. Surguchov A, Palazzo RE, Surgucheva I: Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction. Cell Motil Cytoskeleton. 2001 Aug;49(4):218-28. [PubMed:11746666 ]