Human Metabolome Database: Showing Protein Short transient receptor potential channel 7 (HMDBP08079)

Identification Biological properties Gene properties Protein properties External links References XML Show 9290 metabolites

Identification

HMDB Protein ID

HMDBP08079

Secondary Accession Numbers

13790

Name

Short transient receptor potential channel 7

Synonyms

TRP-7
Transient receptor protein 7
TrpC7
hTRP7

Gene Name

TRPC7

Protein Type

Unknown

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
membrane part
intrinsic to membrane
integral to membrane
cell part
Function
transmembrane transporter activity
calcium channel activity
cation channel activity
ion channel activity
ion transmembrane transporter activity
substrate-specific transmembrane transporter activity
transporter activity
Process
cation transport
ion transport
transmembrane transport
transport
establishment of localization
di-, tri-valent inorganic cation transport
divalent metal ion transport
calcium ion transport

Cellular Location

Membrane
Multi-pass membrane protein (Probable)

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31.1

SNPs

TRPC7

Gene Sequence

>2589 bp
ATGTTGAGGAACAGCACCTTCAAAAACATGCAGCGCCGGCACACAACGCTGAGGGAGAAG
GGCCGTCGCCAGGCCATCCGGGGTCCCGCCTACATGTTCAACGAGAAGGGCACCAGTCTG
ACGCCCGAGGAGGAGCGCTTCCTGGACTCGGCTGAGTATGGCAACATCCCGGTGGTCCGG
AAAATGCTGGAGGAGTCCAAGACCCTTAACTTCAACTGTGTGGACTACATGGGGCAGAAC
GCTCTGCAGCTGGCCGTGGGCAACGAGCACCTAGAGGTCACGGAGCTGCTGCTGAAGAAG
GAGAACCTGGCACGGGTGGGGGACGCGCTGCTGCTGGCCATCAGCAAGGGCTATGTGCGC
ATCGTGGAGGCCATCCTCAACCACCCGGCCTTCGCGCAGGGCCAGCGCCTGACGCTCAGC
CCGCTGGAACAGGAGCTGCGCGACGACGACTTCTATGCCTACGACGAGGACGGCACGCGC
TTCTCCCACGACATCACGCCCATCATCCTGGCGGCGCACTGCCAGGAGTATGAGATCGTG
CACATCCTGCTGCTCAAGGGCGCCCGCATCGAGCGGCCCCACGACTACTTCTGCAAGTGC
AATGAGTGCACCGAGAAACAGCGGAAAGACTCCTTCAGCCACTCGCGCTCGCGCATGAAC
GCCTACAAAGGACTGGCGAGTGCTGCCTACTTGTCCCTGTCCAGCGAAGACCCTGTCCTC
ACCGCCCTGGAGCTCAGCAACGAGTTAGCCAGACTAGCCAACATTGAGACTGAATTTAAG
AACGATTACAGGAAGTTATCTATGCAATGCAAGGATTTTGTAGTGGGCGTGCTGGACCTG
TGCCGAGACACAGAAGAGGTGGAAGCAATTTTAAACGGTGATGTGAACTTCCAAGTCTGG
TCCGACCACCACCGTCCAAGTCTGAGCCGGATCAAACTCGCCATTAAATATGAAGTCAAG
AAGTTCGTTGCTCATCCTAACTGTCAGCAGCAATTGCTTACCATGTGGTATGAAAATCTC
TCAGGCTTACGTCAACAGTCTATCGCTGTGAAATTCCTGGCTGTCTTTGGAGTCTCCATA
GGCCTCCCTTTTCTCGCCATAGCCTATTGGATTGCTCCGTGCAGCAAGCTAGGACGAACC
CTGAGGAGCCCTTTCATGAAGTTTGTAGCTCATGCAGTTTCTTTTACAATCTTCTTGGGA
TTATTAGTTGTGAATGCATCTGACCGATTTGAAGGTGTTAAAACCCTGCCAAACGAAACC
TTCACAGACTACCCAAAACAAATCTTCAGAGTGAAAACCACACAGTTCTCCTGGACAGAA
ATGCTCATTATGAAGTGGGTCTTAGGAATGATTTGGTCCGAATGCAAGGAAATCTGGGAG
GAGGGGCCACGGGAGTACGTGCTGCACTTGTGGAACCTGCTAGATTTCGGGATGCTGTCC
ATCTTCGTGGCCTCCTTCACAGCACGCTTCATGGCCTTCCTGAAGGCCACGGAGGCACAG
CTGTACGTGGACCAGCACGTGCAGGACGACACGCTGCACAATGTCTCGCTTCCGCCGGAA
GTGGCATACTTCACCTACGCCAGGGACAAGTGGTGGCCTTCAGACCCTCAGATCATATCG
GAAGGGCTCTACGCGATAGCCGTCGTGCTGAGCTTCTCTCGCATTGCATACATTCTGCCA
GCCAACGAGAGTTTTGGGCCCCTGCAGATCTCGCTAGGGAGAACTGTGAAAGATATCTTC
AAGTTCATGGTCATTTTCATCATGGTATTTGTGGCCTTCATGATTGGGATGTTCAACCTG
TACTCTTACTACCGAGGTGCCAAATACAACCCAGCGTTTACAACGGTTGAAGAAAGTTTT
AAAACTTTGTTTTGGTCCATATTCGGCTTATCTGAAGTAATCTCAGTGGTGCTGAAATAC
GACCACAAATTCATCGAGAACATTGGCTACGTTCTCTACGGCGTTTATAACGTCACCATG
GTGGTAGTGTTGCTCAACATGCTAATAGCCATGATAAACAACTCCTATCAGGAAATTGAG
GAGGATGCAGATGTGGAATGGAAGTTCGCCCGAGCAAAACTCTGGCTGTCTTACTTTGAT
GAAGGAAGAACTCTACCTGCTCCTTTTAATCTAGTGCCAAGTCCTAAATCATTTTATTAT
CTCATAATGAGAATCAAGATGTGCCTCATAAAACTCTGCAAATCTAAGGCCAAAAGCTGT
GAAAATGACCTTGAAATGGGCATGCTGAATTCCAAATTCAAGAAGACTCGCTACCAGGCT
GGCATGAGGAATTCTGAAAATCTGACAGCAAATAACACTTTGAGCAAGCCCACCAGATAC
CAGAAAATCATGAAACGGCTCATAAAAAGATACGTCCTGAAAGCCCAGGTGGACAGAGAA
AATGACGAAGTCAATGAAGGCGAGCTGAAGGAAATCAAGCAAGATATCTCCAGCCTGCGC
TATGAGCTTCTTGAGGAAAAATCTCAAGCTACTGGTGAGCTGGCAGACCTGATTCAACAA
CTCAGCGAGAAGTTTGGAAAGAACTTAAACAAAGACCACCTGAGGGTGAACAAGGGCAAA
GACATTTAG

Protein Properties

Number of Residues

862

Molecular Weight

99561.3

Theoretical pI

7.98

Pfam Domain Function

Ion_trans (PF00520 )
TRP_2 (PF08344 )

Signals

None

Transmembrane Regions

352-372
384-404
466-486
538-558
582-602
652-672

Protein Sequence

>Short transient receptor potential channel 7
MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVR
KMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVR
IVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIV
HILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVL
TALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVW
SDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSI
GLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNET
FTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLS
IFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIIS
EGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNL
YSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTM
VVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYY
LIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRY
QKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQ
LSEKFGKNLNKDHLRVNKGKDI

External Links

GenBank ID Protein

9798452

UniProtKB/Swiss-Prot ID

Q9HCX4

UniProtKB/Swiss-Prot Entry Name

TRPC7_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Lussier MP, Cayouette S, Lepage PK, Bernier CL, Francoeur N, St-Hilaire M, Pinard M, Boulay G: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. J Biol Chem. 2005 May 13;280(19):19393-400. Epub 2005 Mar 9. [PubMed:15757897 ]
Lussier MP, Lepage PK, Bousquet SM, Boulay G: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. Cell Calcium. 2008 May;43(5):432-43. Epub 2007 Sep 11. [PubMed:17850865 ]