Human Metabolome Database: Showing Protein A-kinase anchor protein SPHKAP (HMDBP08174)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification
HMDB Protein ID	HMDBP08174
Secondary Accession Numbers	13885
Name	A-kinase anchor protein SPHKAP
Synonyms	SPHK1-interactor and AKAP domain-containing protein Sphingosine kinase type 1-interacting protein
Gene Name	SPHKAP
Protein Type	Unknown
Biological Properties
General Function	Involved in protein binding
Specific Function	Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1
Pathways	Not Available
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Cytoplasm
Gene Properties
Chromosome Location	Chromosome:2
Locus	2q36
SNPs	SPHKAP
Gene Sequence	>5103 bp ATGGATGGCAACTCCCTGCTCTCGGTACCAAGCAACTTGGAGTCATCACGGATGTATGAC GTTTTGGAACCGCAGCAGGGCAGAGGCTGTGGCAGCTCAGGAAGCGGCCCGGGGAACTCC ATCACAGCCTGTAAGAAGGTTCTTCGCAGCAATAGCCTGCTGGAGTCAACAGACTACTGG TTGCAGAATCAGAGGATGCCCTGCCAAATTGGTTTTGTAGAAGACAAGTCTGAAAACTGT GCTTCTGTCTGCTTTGTGAATCTTGATGTGAACAAGGATGAATGCAGCACAGAGCACCTG CAACAGAAACTGGTCAACGTTTCACCAGATCTTCCAAAACTTATCAGTTCCATGAATGTC CAACAACCAAAAGAAAATGAAATTGTTGTCCTAAGTGGGTTAGCCTCTGGAAATCTCCAG GCAGATTTTGAAGTTTCACAGTGCCCTTGGCTGCCAGATATCTGCTTGGTCCAATGTGCA AGAGGGAACAGACCAAACAGTACCAACTGCATCATCTTTGAAATCAACAAATTTCTGATT GGTCTGGAACTGGTGCAGGAGCGACAGCTCCACCTGGAAACAAACATCTTGAAACTGGAG GATGACACGAACTGTTCCTTATCTTCAATCGAGGAAGACTTTCTCACCGCTTCTGAGCAC TTGGAGGAGGAAAGCGAGGTGGATGAATCTAGGAACGATTATGAAAATATAAATGTCTCA GCCAATGTTTTGGAAAGTAAACAGCTAAAGGGAGCCACCCAGGTGGAATGGAATTGCAAC AAGGAAAAGTGGCTTTATGCTTTGGAAGACAAATACATCAACAAATATCCCACACCATTG ATTAAAACAGAACGATCTCCAGAAAACCTAACAAAGAACACAGCCTTGCAGAGTCTAGAT CCCTCAGCCAAGCCATCACAGTGGAAAAGAGAAGCTGTGGGGAATGGGAGACAAGCCACA CATTATTATCATTCAGAAGCTTTTAAAGGTCAAATGGAAAAATCACAGGCACTGTATATT CCAAAAGATGCTTATTTCTCCATGATGGATAAAGATGTACCTTCTGCATGTGCTGTGGCA GAGCAGAGAAGCAACCTAAACCCAGGAGACCATGAAGACACAAGAAACGCTCTCCCTCCT AGACAAGATGGAGAAGTCACCACTGGCAAGTATGCTACAAATTTAGCAGAATCCGTGCTG CAGGATGCATTTATTAGATTATCTCAATCTCAGTCCACATTACCCCAGGAATCTGCAGTC AGTGTTTCTGTAGGAAGTTCTCTGCTTCCCAGTTGCTATTCCACAAAAGATACAGTGGTT TCTCGGTCATGGAATGAGCTCCCCAAAATCGTCGTTGTTCAGAGTCCAGATGGCAGTGAT GCTGCCCCACAGCCAGGCATCTCCTCCTGGCCTGAGATGGAAGTCTCTGTTGAAACCTCA AGCATCCTCTCTGGAGAGAACTCCAGCAGACAACCCCAGAGTGCTCTAGAAGTGGCGTTA GCTTGTGCAGCCACTGTGATTGGAACTATTTCCAGTCCACAGGCCACAGAAAGACTCAAA ATGGAGCAAGTGGTCTCGAACTTTCCCCCAGGGAGCAGTGGTGCACTGCAAACTCAAGCA CCCCAAGGACTCAAGGAACCTTCCATCAATGAGTACTCCTTTCCATCTGCTTTGTGTGGC ATGACTCAGGTGGCCAGTGCCGTGGCTGTCTGTGGTCTGGGTGAAAGAGAAGAGGTGACA TGCTCAGTGGCTCCAAGTGGTAGCCTCCCGCCTGCAGCTGAGGCTTCTGAAGCCATGCCC CCACTTTGTGGTTTAGCAAGCATGGAGCTTGGCAAGGAAGCCATTGCCAAGGGATTGCTC AAGGAGGCTGCTCTGGTTTTAACAAGGCCTAATACCTACAGCAGCATTGGAGACTTTCTG GACTCCATGAACAGGAGAATCATGGAAACTGCTTCAAAGTCTCAGACCCTGTGCTCAGAA AATGTCGTCAGGAATGAACTGGCACATACCCTGTCCAATGTTATCCTGAGGCATTCCATT GATGAAGTTCACCACAAAAATATGATAATCGACCCCAATGACAACAGGCATTCATCTGAA ATTCTGGACACCTTAATGGAAAGTACAAATCAACTGCTTTTAGATGTGATATGCTTCACG TTCAAGAAGATGAGTCATATTGTACGGCTTGGTGAATGTCCTGCTGTCCTTTCTAAGGAG ACCATCAGAAGGAGGGAGACAGAACCAAGCTGCCAGCCATCTGATCCGGGTGCTAGTCAA GCTTGGACAAAAGCCACTGAATCCTCCAGCAGCTCTCCACTTAGCAATTCACACAACACG AGTCTTGTCATCAACAATCTTGTGGATGGCATGTATTCAAAACAAGACAAGGGTGGAGTG AGGCCAGGCCTCTTCAAGAACCCCACGCTGCAGTCACAATTATCACGTAGTCACAGAGTG CCCGATTCTTCAACTGCTACAACATCCTCCAAGGAAATATATCTGAAAGGAATAGCAGGA GAGGATACAAAAAGCCCTCATCACAGTGAGAATGAATGCAGAGCCTCTTCCGAAGGACAA AGGTCCCCAACGGTCAGCCAGTCCAGAAGTGGTTCCCAGGAGGCTGAGGAGAGTATCCAC CCAAACACCCAAGAAAAGTACAACTGTGCCACATCTCGCATCAACGAAGTTCAAGTCAAC CTGTCCTTGTTAGGGGATGACCTGCTGCTTCCTGCTCAATCCACGCTTCAAACAAAGCAT CCAGACATCTACTGCATTACAGACTTTGCGGAAGAATTAGCAGACACGGTCGTCTCCATG GCAACTGAAATTGCAGCGATTTGCCTTGACAACTCCAGTGGAAAACAACCCTGGTTTTGT GCATGGAAAAGAGGGAGTGAGTTTCTGATGACACCCAACGTACCCTGCCGATCCTTGAAG AGGAAGAAAGAGAGCCAGGGGAGCGGGACCGCTGTGAGGAAACACAAGCCTCCCCGGCTC AGTGAGATCAAGAGGAAGACGGACGAGCACCCTGAGCTTAAAGAAAAGCTGATGAACAGG GTTGTGGATGAGTCCATGAACCTTGAAGATGTCCCAGATTCTGTCAATCTTTTTGCCAAT GAAGTGGCAGCCAAGATCATGAACCTAACGGAGTTCTCTATGGTGGACGGCATGTGGCAG GCGCAGGGCTATCCCCGGAATCGGTTACTGAGTGGCGACAGGTGGAGCCGGCTGAAGGCC TCCAGCTGCGAAAGCATTCCTGAGGAAGACTCCGAGGCCAGGGCCTATGTCAACAGCCTG GGCTTAATGAGCACGCTGAGCCAGCCGGTCAGCAGGGCCAGCTCTGTCTCCAAGCAGTCG AGCTGTGAGAGCATCACCGATGAGTTTTCCAGGTTCATGGTGAACCAGATGGAAAATGAA GGGAGAGGATTTGAGTTACTGCTGGATTACTATGCTGGCAAGAACGCCAGCAGCATTCTG AACTCAGCCATGCAACAGGCGTGCCGGAAAAGTGACCACCTCAGTGTGAGGCCTAGCTGT CCCTCTAAGCAGTCCAGCACAGAGAGCATCACTGAGGAGTTCTACAGGTACATGCTGAGG GACATCGAAAGAGACAGCAGAGAAAGTGCCTCCTCCAGACGGAGCAGCCAGGATTGGACA GCCGGCCTGCTGTCTCCTTCTCTGCGATCCCCAGTGTGCCACAGACAGTCGTCCATGCCA GACAGCAGATCCCCATGCTCCAGGCTGACAGTGAATGTGCCCATCAAAGCCAACTCTTTA GATGGCTTTGCTCAGAACTGCCCACAAGATTTCCTAAGCGTGCAGCCGGTCAGTAGCGCG TCCTCATCCGGTCTCTGCAAATCTGACTCTTGCTTGTATCGGAGAGGTGGGACTGACCAC ATCACCAACATGTTAATTCATGAAACGTGGGCTAGCTCCATTGAGGCTCTCATGCGCAAG AACAAAATCATTGTGGATGATGCAGAGGAAGCTGACACTGAGCCTGTTTCTGGTGGCTCT CCCTCGCAAGCAGAGAAGTGTGCAAATAGATTAGCTGCGAGCAGGATGTGCAGTGGGCCA ACTCTGCTTGTTCAGGAGTCTCTCGATTGCCCGAGGAAAGACTCTGTTACCGAATGTAAA CAGCCCCCAGTGTCATCTTTGAGCAAAACTGCTTCTCTTACAAACCACAGCCCTTTAGAT TCTAAAAAAGAAACTTCCTCGTGCCAGGACCCTGTACCAATAAACCACAAAAGGCGATCA CTTTGCTCGAGGGAAGTGCCTTTGATTCAGATTGAAACAGATCAGAGAGAAGCCTGTGCT GGGGAACCTGAACCCTTCCTTTCCAAAAGCAGCCTCCTAGAGGAAGCAGAAGGGCATTCG AATGACAAAAACATCCCAGATGTGGTGAGAGGTGGAGACACAGCCGTGAGCGCTTGTCAA ATCCATAGTGACAGCCTTGATACCAGAGATGTACCAGAGGCTGAAGCCTCCACAGAAGCC AGAGCCCCCGATGAGGCCCCCAACCCTCCAAGCAGCAGCGAGGAGAGCACAGGCAGCTGG ACCCAGCTTGCCAATGAGGAAGACAACCCAGATGACACAAGTAGCTTTCTCCAGCTCAGT GAGCGATCCATGAGCAATGGCAACAGTAGTGCCACTAGCAGTCTTGGCATTATGGATCTG GACATTTATCAGGAAAGCATGCCATCTTCTCCCATGATTAATGAATTAGTAGAAGAAAAG AAGATTCTTAAAGGACAGTCAGAAAGCACAGAGGCACCTGCATCTGGACCGCCTACGGGA ACAGCCAGCCCCCAGAGGAGCCTGCTGGTGATCAACTTTGACCTGGAGCCAGAGTGTCCA GATGCCGAGCTCCGAGCCACTCTGCAGTGGATAGCTGCCTCTGAACTGGGGATTCCCACC ATCTACTTTAAGAAATCTCAGGAAAACAGAATTGAAAAGTTTCTAGATGTCGTGCAGCTG GTTCATCGGAAGTCCTGGAAAGTGGGTGATATCTTCCATGCAGTTGTCCAGTACTGCAAA ATGCATGAGGAGCAGAAGGATGGGAGACTGAGTCTCTTTGACTGGCTCTTGGAACTGGGA TAA
Protein Properties
Number of Residues	1700
Molecular Weight	186454.3
Theoretical pI	4.78
Pfam Domain Function	AKAP_110 (PF05716 )
Signals	None
Transmembrane Regions	None
Protein Sequence	>A-kinase anchor protein SPHKAP MDGNSLLSVPSNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYW LQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNV QQPKENEIVVLSGLASGNLQADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLI GLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVS ANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLD PSAKPSQWKREAVGNGRQATHYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVA EQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAV SVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETS SILSGENSSRQPQSALEVALACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQA PQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMP PLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSE NVVRNELAHTLSNVILRHSIDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFT FKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNT SLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAG EDTKSPHHSENECRASSEGQRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVN LSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFC AWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNR VVDESMNLEDVPDSVNLFANEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKA SSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENE GRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLR DIERDSRESASSRRSSQDWTAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSL DGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRK NKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECK QPPVSSLSKTASLTNHSPLDSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACA GEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEA RAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDL DIYQESMPSSPMINELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECP DAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCK MHEEQKDGRLSLFDWLLELG
External Links
GenBank ID Protein	85397610
UniProtKB/Swiss-Prot ID	Q2M3C7
UniProtKB/Swiss-Prot Entry Name	SPKAP_HUMAN
PDB IDs	Not Available
GenBank Gene ID	BC104954
GeneCard ID	SPHKAP
GenAtlas ID	SPHKAP
HGNC ID	HGNC:30619
References
General References	Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ] Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ] Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Dec 31;7(6):347-55. [PubMed:11214970 ] Lacana E, Maceyka M, Milstien S, Spiegel S: Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. J Biol Chem. 2002 Sep 6;277(36):32947-53. Epub 2002 Jun 21. [PubMed:12080051 ]