Hmdb loader
Identification
HMDB Protein ID HMDBP08195
Secondary Accession Numbers
  • 13906
Name Chloride intracellular channel protein 6
Synonyms
  1. Parchorin
Gene Name CLIC6
Protein Type Unknown
Biological Properties
General Function Involved in voltage-gated chloride channel activity
Specific Function May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
ion channel activity
anion channel activity
chloride channel activity
voltage-gated chloride channel activity
Process
establishment of localization
transport
ion transport
anion transport
inorganic anion transport
chloride transport
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Single-pass membrane protein
Gene Properties
Chromosome Location Chromosome:2
Locus 21q22.12
SNPs CLIC6
Gene Sequence
>2115 bp
ATGGCCGAGGCCGCGGAGCCGGAGGGGGTTGCCCCGGGTCCCCAGGGGCCGCCGGAGGTC
CCCGCGCCTCTGGCTGAGAGACCCGGAGAGCCAGGAGCCGCGGGCGGGGAGGCAGAAGGG
CCGGAGGGGAGCGAGGGCGCAGAGGAGGCGCCGAGGGGCGCCGCCGCTGTGAAGGAGGCA
GGAGGCGGCGGGCCAGACAGGGGCCCGGAGGCCGAGGCGCGGGGCACGAGGGGGGCGCAC
GGCGAGACTGAGGCCGAGGAGGGAGCCCCGGAGGGTGCCGAGGTGCCCCAAGGAGGGGAG
GAGACAAGCGGCGCGCAGCAGGTGGAGGGGGCGAGCCCGGGACGCGGCGCGCAGGGCGAG
CCCCGCGGGGAGGCTCAGAGGGAGCCCGAGGACTCTGCGGCCCCCGAGAGGCAGGAGGAG
GCGGAGCAGAGGCCTGAGGTCCCGGAAGGTAGCGCGTCCGGGGAGGCGGGGGACAGCGTA
GACGCGGAGGGCCCGCTGGGGGACAACATAGAAGCGGAGGGCCCGGCGGGCGACAGCGTA
GAGGCGGAGGGCCGGGTGGGGGACAGCGTAGACGCGGAAGGTCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCCGCTGGGGGACAACATACAAGCCGAGGGCCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCGGGTGGGGGACAGCGTAGACGCGGAAGGTCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCGGGTGGGGGACAGCGTAGAGGCGGGGGACCCGGCGGGGGACGGCGTA
GAAGCGGGGGTCCCGGCGGGGGACAGCGTAGAAGCCGAAGGCCCGGCGGGGGACAGCATG
GACGCCGAGGGTCCGGCAGGAAGGGCGCGCCGGGTCTCGGGTGAGCCGCAGCAATCGGGG
GACGGCAGCCTCTCGCCCCAGGCCGAGGCAATTGAGGTCGCAGCCGGGGAGAGTGCGGGG
CGCAGCCCCGGTGAGCTCGCCTGGGACGCAGCGGAGGAGGCGGAGGTCCCGGGGGTAAAG
GGGTCCGAAGAAGCGGCCCCCGGGGACGCAAGGGCAGACGCTGGCGAGGACAGGGTAGGG
GATGGGCCACAGCAGGAGCCGGGGGAGGACGAAGAGAGACGAGAGCGGAGCCCGGAGGGG
CCAAGGGAGGAGGAAGCAGCGGGGGGCGAAGAGGAATCCCCCGACAGCAGCCCACATGGG
GAGGCCTCCAGGGGCGCCGCGGAGCCTGAGGCCCAGCTCAGCAACCACCTGGCCGAGGAG
GGCCCCGCCGAGGGTAGCGGCGAGGCCGCGCGCGTGAACGGCCGCCGGGAGGACGGAGAG
GCGTCCGAGCCCCGGGCCCTGGGGCAGGAGCACGACATCACCCTCTTCGTCAAGGTAAAA
CTTACTGCATTAGGCTGTTCTCGCATTGCTATAAAGAAATACCTGAGAGCTGGTTATGAT
GGTGAGAGTATCGGAAATTGCCCGTTTTCTCAGCGTCTCTTTATGATTCTCTGGCTGAAA
GGCGTTATATTTAATGTGACCACAGTGGACCTGAAAAGGAAACCCGCAGACCTGCAGAAC
CTGGCTCCCGGAACAAACCCTCCTTTCATGACTTTTGATGGTGAAGTCAAGACGGATGTG
AATAAGATCGAGGAGTTCTTAGAGGAGAAATTAGCTCCCCCGAGGTATCCCAAGCTGGGG
ACCCAACATCCCGAATCTAATTCCGCAGGAAATGACGTGTTTGCCAAATTCTCAGCGTTT
ATAAAAAACACGAAGAAGGATGCAAATGAGATTCATGAAAAGAACCTGCTGAAGGCCCTG
AGGAAGCTGGATAATTACTTAAATAGCCCTCTGCCTGATGAAATAGATGCCTACAGCACC
GAGGATGTCACTGTTTCTGGAAGGAAGTTTCTGGATGGGGACGAGCTGACGCTGGCTGAC
TGCAACCTCTTACCCAAGCTCCATATTATTAAGATTGTGGCCAAGAAGTACAGAGATTTT
GAATTTCCTTCTGAAATGACTGGCATCTGGAGATACTTGAATAATGCTTATGCTAGAGAT
GAGTTCACAAATACGTGTCCAGCTGATCAAGAGATTGAACACGCATATTCAGATGTTGCA
AAAAGAATGAAATGA
Protein Properties
Number of Residues 704
Molecular Weight 73010.9
Theoretical pI 4.01
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 489-509
Protein Sequence
>Chloride intracellular channel protein 6
MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEA
GGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGE
PRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSV
EAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSV
DAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSG
DGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVG
DGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEE
GPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYD
GESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDV
NKIEEFLEEKLAPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKAL
RKLDNYLNSPLPDEIDAYSTEDVTVSGRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDF
EFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVAKRMK
GenBank ID Protein 25990944
UniProtKB/Swiss-Prot ID Q96NY7
UniProtKB/Swiss-Prot Entry Name CLIC6_HUMAN
PDB IDs Not Available
GenBank Gene ID AF448439
GeneCard ID CLIC6
GenAtlas ID CLIC6
HGNC ID HGNC:2065
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  3. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML: The DNA sequence of human chromosome 21. Nature. 2000 May 18;405(6784):311-9. [PubMed:10830953 ]
  4. Friedli M, Guipponi M, Bertrand S, Bertrand D, Neerman-Arbez M, Scott HS, Antonarakis SE, Reymond A: Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12. Gene. 2003 Nov 27;320:31-40. [PubMed:14597386 ]
  5. Strippoli P, D'Addabbo P, Lenzi L, Giannone S, Canaider S, Casadei R, Vitale L, Carinci P, Zannotti M: Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q. Mamm Genome. 2002 Aug;13(8):456-62. [PubMed:12226712 ]