Hmdb loader
Identification
HMDB Protein ID HMDBP08464
Secondary Accession Numbers
  • 14176
Name Importin-13
Synonyms
  1. Imp13
  2. Kap13
  3. Karyopherin-13
  4. Ran-binding protein 13
  5. RanBP13
Gene Name IPO13
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
transporter activity
substrate-specific transporter activity
protein transporter activity
Process
establishment of localization
transport
protein transport
intracellular protein transport
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 1p34.1
SNPs IPO13
Gene Sequence
>2892 bp
ATGGAGCGGCGGGAGGAGCAGCCGGGGGCTGCAGGGGCTGGAGCAGCACCAGCCTTGGAC
TTCACTGTGGAGAACGTGGAGAAGGCGCTGCACCAGCTCTACTATGATCCCAACATTGAG
AATAAGAACCTGGCTCAGAAGTGGCTGATGCAGGCCCAGGTCTCCCCACAGGCCTGGCAC
TTCAGCTGGCAGCTACTGCAGCCCGACAAGGTACCAGAGATCCAGTACTTTGGGGCCAGT
GCTCTTCACATCAAGATCTCTCGCTACTGGAGTGACATCCCCACTGACCAGTATGAAAGC
CTAAAGGCACAGCTCTTCACCCAGATCACCCGCTTTGCCAGTGGCTCCAAGATTGTACTG
ACTCGGCTGTGCGTGGCACTGGCCTCACTGGCTCTCAGCATGATGCCTGACGCTTGGCCA
TGTGCTGTGGCAGATATGGTACGACTCTTCCAGGCTGAGGACTCACCAGTGGATGGGCAG
GGCCGCTGCCTAGCCCTGTTAGAGCTGCTGACAGTGCTGCCTGAGGAGTTCCAGACCAGT
CGCCTACCCCAGTACCGCAAAGGCCTGGTGCGGACCAGCCTGGCGGTGGAATGTGGGGCT
GTCTTCCCGCTGCTGGAGCAGCTGCTACAGCAGCCCAGCTCACCCAGCTGTGTGCGTCAG
AAGGTGCTCAAGTGTTTCTCCAGCTGGGTGCAGCTGGAGGTGCCGCTGCAGGACTGTGAG
GCGCTCATTCAGGCTGCCTTTGCTGCTCTGCAGGACTCGGAGCTCTTCGACAGCAGTGTG
GAGGCCATTGTGAATGCCATCTCACAGCCTGATGCCCAGAGGTACGTGAACACACTCCTG
AAACTCATCCCGCTGGTGCTGGGTCTGCAGGAACAACTGCGGCAGGCAGTGCAGAATGGG
GACATGGAGACCTCCCATGGCATCTGTCGCATCGCTGTGGCCCTGGGCGAGAACCACTCC
CGGGCCTTGCTGGACCAAGTAGAGCACTGGCAGAGTTTCCTGGCACTCGTCAACATGATT
ATGTTCTGCACAGGCATCCCTGGCCACTATCCTGTCAATGAGACCACCAGCTCCCTAACC
CTCACCTTCTGGTACACACTGCAGGATGATATTCTATCCTTTGAGGCAGAGAAGCAGGCT
GTATACCAGCAGGTGTACCGGCCAGTCTACTTCCAGCTGGTGGATGTGCTTCTGCACAAG
GCCCAGTTCCCTTCTGATGAGGAATATGGATTCTGGTCCTCAGACGAGAAGGAGCAGTTC
CGAATTTACAGGGTGGACATCTCAGACACGCTCATGTATGTCTATGAGATGTTGGGGGCC
GAGCTGCTCAGCAACCTCTATGACAAGCTGGGTCGTTTGCTCACCAGCTCAGAGGAGCCC
TACTCCTGGCAGCACACAGAGGCCCTCCTCTACGGCTTCCAATCCATCGCAGAGACCATT
GACGTCAACTATTCTGATGTGGTGCCTGGGCTCATTGGCCTCATCCCACGGATCAGCATC
AGCAACGTGCAGCTGGCAGACACTGTCATGTTCACCATTGGAGCTCTGTCTGAATGGCTG
GCTGACCACCCCGTCATGATCAACAGTGTTCTGCCCTTGGTACTGCATGCCCTAGGCAAT
CCTGAGCTGTCTGTCTCTTCTGTGTCCACCCTCAAGAAGATCTGCCGAGAGTGCAAGTAT
GACCTGCCTCCCTATGCTGCCAACATTGTGGCTGTGTCCCAGGATGTGCTGATGAAACAG
ATCCACAAGACAAGCCAGTGCATGTGGCTGATGCAGGCGCTGGGCTTCCTGCTGTCAGCT
CTTCAAGTGGAGGAGATCCTTAAGAACCTGCACTCGCTTATCTCACCCTATATCCAGCAA
CTGGAGAAGCTGGCAGAGGAGATACCCAATCCCTCCAACAAGCTGGCCATTGTTCACATC
TTGGGGCTTCTCTCCAACCTCTTCACCACACTGGACATCAGTCATCATGAGGATGATCAT
GAAGGCCCTGAGCTTCGGAAGCTGCCAGTGCCACAGGGACCCAACCCCGTGGTGGTGGTG
CTGCAGCAGGTCTTCCAGCTTATCCAGAAGGTGCTGAGCAAATGGTTGAATGATGCCCAG
GTTGTGGAGGCGGTGTGCGCTATCTTTGAGAAGTCTGTTAAGACGCTGCTGGATGACTTT
GCCCCCATGGTGCCACAGCTGTGTGAGATGCTGGGTCGGATGTACAGCACCATCCCCCAG
GCCTCTGCTCTTGACCTCACTCGACAGCTGGTCCACATCTTTGCTCATGAGCCTGCCCAC
TTTCCCCCAATTGAGGCCCTCTTCCTGCTCGTCACCTCCGTCACACTCACTCTCTTCCAG
CAAGGGCCCAGGGATCATCCTGATATTGTTGATTCATTTATGCAACTCCTGGCACAGGCT
CTGAAGCGGAAGCCAGATTTGTTCCTGTGTGAACGATTGGATGTCAAAGCTGTGTTCCAG
TGTGCTGTGCTGGCCCTCAAGTTCCCTGAGGCACCTACTGTCAAGGCCTCCTGTGGCTTC
TTTACAGAGCTGCTGCCTCGGTGTGGGGAAGTAGAGTCTGTGGGAAAGGTGGTACAGGAA
GACGGTCGTATGCTGCTCATAGCAGTGCTGGAGGCCATTGGGGGCCAGGCCTCCCGCAGC
CTCATGGACTGCTTTGCCGATATCCTGTTCGCCCTGAACAAGCACTGCTTCAGCCTCCTG
AGCATGTGGATCAAGGAGGCCCTGCAGCCACCTGGTTTCCCCTCTGCCCGCCTCAGCCCT
GAACAGAAGGATACCTTCAGCCAGCAGATCCTTCGCGAGCGAGTGAACAAGAGGCGGGTG
AAGGAGATGGTGAAGGAGTTCACACTGCTGTGCCGGGGTCTCCATGGCACAGATTACACA
GCTGACTACTGA
Protein Properties
Number of Residues 963
Molecular Weight 108194.1
Theoretical pI 4.95
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Importin-13
MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWH
FSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVL
TRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTS
RLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCE
ALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNG
DMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLT
LTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQF
RIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETI
DVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGN
PELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSA
LQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDH
EGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDF
APMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQ
QGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGF
FTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLL
SMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYT
ADY
GenBank ID Protein 224831257
UniProtKB/Swiss-Prot ID O94829
UniProtKB/Swiss-Prot Entry Name IPO13_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014652.3
GeneCard ID IPO13
GenAtlas ID IPO13
HGNC ID HGNC:16853
References
General References
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