Human Metabolome Database: Showing Protein Nucleolar GTP-binding protein 2 (HMDBP08491)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP08491

Secondary Accession Numbers

14203

Name

Nucleolar GTP-binding protein 2

Synonyms

Autoantigen NGP-1

Gene Name

GNL2

Protein Type

Unknown

Biological Properties

General Function

Involved in GTP binding

Specific Function

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
intracellular
Function
binding
nucleotide binding
purine nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding

Cellular Location

Nucleus
nucleolus

Gene Properties

Chromosome Location

Chromosome:1

Locus

1p34.3

SNPs

GNL2

Gene Sequence

>2196 bp
ATGGTGAAGCCCAAGTACAAAGGACGGAGCACCATCAACCCGTCCAAGGCCAGCACAAAC
CCAGATCGAGTGCAGGGAGCAGGAGGCCAAAACATGAGGGACCGGGCCACCATCCGGCGC
CTGAATATGTATAGGCAAAAGGAGCGCAGGAACAGTCGTGGTAAAATAATTAAACCCCTG
CAATATCAATCAACGGTGGCTTCTGGCACAGTGGCAAGAGTAGAGCCAAATATTAAATGG
TTTGGAAACACACGTGTGATTAAGCAGTCATCATTACAAAAATTTCAAGAGGAAATGGAT
ACAGTTATGAAGGATCCATACAAAGTTGTCATGAAGCAAAGCAAGTTACCAATGTCTCTT
CTCCATGATCGAATCCGGCCTCATAACTTGAAGGTGCACATTCTTGATACTGAAAGTTTT
GAAACTACATTTGGCCCTAAGTCACAGAGGAAACGACCAAACTTATTTGCAAGTGATATG
CAGTCTCTTATCGAAAATGCTGAAATGTCCACTGAGAGCTATGACCAGGGCAAGGATCGT
GATTTGGTAACTGAAGACACTGGTGTGAGAAATGAAGCTCAAGAAGAGATCTATAAAAAG
GGACAGTCCAAAAGAATATGGGGTGAGCTCTACAAGGTGATAGATTCATCAGATGTTGTA
GTTCAAGTTCTTGATGCTAGAGATCCAATGGGTACTCGTTCCCCTCACATTGAAACTTAC
CTGAAGAAGGAAAAACCTTGGAAACACCTCATTTTTGTACTTAACAAATGTGACCTTGTT
CCAACCTGGGCAACAAAACGGTGGGTTGCTGTCCTCTCCCAGGATTATCCAACACTTGCT
TTCCATGCAATCCTTACTAACCCGTTTGGCAAGGGAGCATTCATTCAGCTTCTGCGGCAG
TTTGGAAAGTTGCACACTGACAAGAAACAGATCAGTGTTGGGTTCATTGGCTATCCAAAT
GTTGGCAAGAGCTCTGTGATAAATACATTGCGTTCTAAGAAAGTTTGCAACGTGGCTCCC
ATTGCAGGTGAAACAAAGGTCTGGCAGTATATTACTTTGATGCGTCGGATATTCCTGATT
GACTGTCCAGGTGTGGTTTACCCCTCTGAGGACTCCGAGACAGACATTGTGCTAAAAGGA
GTTGTTCAAGTAGAAAAAATTAAGAGTCCTGAAGACCACATTGGTGCTGTACTTGAACGA
GCAAAGCCAGAATATATCAGCAAAACATACAAGATTGATTCTTGGGAGAATGCTGAGGAC
TTTCTTGAGAAGCTCGCTTTCCGGACTGGGAAGTTACTAAAGGGTGGAGAGCCCGACTTG
CAGACTGTGGGTAAGATGGTCCTCAATGACTGGCAGAGGGGCCGGATTCCTTTCTTTGTC
AAGCCACCCAATGCAGAGCCACTTGTGGCCCCCCAGCTTCTACCCTCCTCATCTTTGGAA
GTTGTCCCAGAAGCAGCCCAGAACAATCCAGGGGAGGAAGTCACAGAAACTGCAGGTGAA
GGGTCAGAATCCATCATTAAGGAAGAAACAGAAGAGAACAGTCACTGTGATGCTAACACA
GAGATGCAGCAGATTCTCACACGAGTTCGGCAGAACTTTGGTAAAATCAACGTGGTGCCT
CAGTTTTCTGGGGATGACCTGGTTCCTGTGGAGGTGTCAGATCTTGAGGAAGAGCTTGAG
AGCTTTTCTGATGAAGAGGAGGAGGAACAGGAGCAACAAAGAGATGATGCGGAAGAGTCT
TCCTCGGAGCCTGAGGAGGAAAATGTGGGAAACGACACCAAAGCCGTTATTAAAGCACTG
GATGAGAAGATTGCCAAATATCAGAAGTTTCTAGACAAAGCCAAAGCCAAAAAGTTTTCA
GCAGTCAGAATATCCAAGGGACTGAGTGAAAAGATATTTGCAAAACCTGAAGAACAAAGA
AAAACACTGGAAGAAGATGTAGATGACAGAGCACCTTCCAAAAAGGGAAAGAAGCGGAAG
GCACAAAGGGAAGAGGAACAGGAACATTCAAATAAAGCTCCCAGGGCGCTTACATCAAAA
GAACGGAGGCGAGCAGTACGACAGCAACGGCCGAAAAAAGTTGGTGTGCGCTACTATGAA
ACACACAACGTGAAAAATAGGAACAGGAACAAAAAGAAGACCAATGACTCAGAGGGACAG
AAACACAAACGCAAAAAATTCAGACAAAAGCAGTAA

Protein Properties

Number of Residues

731

Molecular Weight

83654.4

Theoretical pI

9.85

Pfam Domain Function

MMR_HSR1 (PF01926 )
NGP1NT (PF08153 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Nucleolar GTP-binding protein 2
MVKPKYKGRSTINPSKASTNPDRVQGAGGQNMRDRATIRRLNMYRQKERRNSRGKIIKPL
QYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVMKDPYKVVMKQSKLPMSL
LHDRIRPHNLKVHILDTESFETTFGPKSQRKRPNLFASDMQSLIENAEMSTESYDQGKDR
DLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIETY
LKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQ
FGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLI
DCPGVVYPSEDSETDIVLKGVVQVEKIKSPEDHIGAVLERAKPEYISKTYKIDSWENAED
FLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEPLVAPQLLPSSSLE
VVPEAAQNNPGEEVTETAGEGSESIIKEETEENSHCDANTEMQQILTRVRQNFGKINVVP
QFSGDDLVPVEVSDLEEELESFSDEEEEEQEQQRDDAEESSSEPEEENVGNDTKAVIKAL
DEKIAKYQKFLDKAKAKKFSAVRISKGLSEKIFAKPEEQRKTLEEDVDDRAPSKKGKKRK
AQREEEQEHSNKAPRALTSKERRRAVRQQRPKKVGVRYYETHNVKNRNRNKKKTNDSEGQ
KHKRKKFRQKQ

External Links

GenBank ID Protein

12652715

UniProtKB/Swiss-Prot ID

Q13823

UniProtKB/Swiss-Prot Entry Name

NOG2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
Scherl A, Coute Y, Deon C, Calle A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ: Functional proteomic analysis of human nucleolus. Mol Biol Cell. 2002 Nov;13(11):4100-9. [PubMed:12429849 ]
Racevskis J, Dill A, Stockert R, Fineberg SA: Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor. Cell Growth Differ. 1996 Feb;7(2):271-80. [PubMed:8822211 ]