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Showing Protein Transportin-2 (HMDBP08611)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP08611
Secondary Accession Numbers
  • 14326
Name Transportin-2
Synonyms
  1. Karyopherin beta-2b
Gene Name TNPO2
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
transporter activity
substrate-specific transporter activity
protein transporter activity
Process
establishment of localization
transport
protein transport
intracellular protein transport
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.2
SNPs TNPO2
Gene Sequence 
>2694 bp
ATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCA
CAGTCGCCCAACACAGCCACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAG
TTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAGATGAG
CCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGC
TTCCCACCCCCTGTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCC
TCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGCTTCCAAGGGTGAG
CTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTAC
AACACTTGTGAGGGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTT
CTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTC
TTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATC
ATGGACCGGGCCCAGGCGCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCC
CTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTT
CTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTG
CAGAGGACCCAGGACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACG
CTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCAGTTGATCCCC
ATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTG
GAGGAGGATGAGGCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCA
CGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGAT
GACGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTG
GACGTCCTCGCCAATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAA
GGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCC
ATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTG
ATCCAGTGCCTGTCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGC
CGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACA
GAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCT
TTTGCCACCCTGGAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTG
GACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGAC
GCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAG
AAGCTGATGCCCCCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTC
TTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCT
TACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCC
ATGATGTACACCCAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTA
GCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTG
GCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGGACTCGATGCCTGAGGTC
CGGCAGAGCTCCTTTGCCCTCCTGGGAGACCTCACCAAAGCCTGCTTCATCCATGTCAAG
CCCTGTATCGCCGAGTTCATGCCCATTCTGGGCACCAACCTGAACCCAGAGTTCATCTCC
GTCTGCAACAACGCCACCTGGGCCATTGGTGAAATCTGCATGCAGATGGGGGCAGAGATG
CAGCCTTATGTGCAGATGGTCCTCAACAACCTGGTGGAAATCATTAACCGACCCAACACA
CCCAAGACACTGCTGGAAAACACAGGTCGCCTGACGAGTCCCTCTGCCATTCCAGCCATC
ACCATCGGCCGCTTGGGCTACGTGTGCCCCCAGGAGGTGGCACCCATGCTGCAGCAGTTC
ATCCGGCCTTGGTGCACGTCCCTCAGGAACATCAGGGACAACGAGGAGAAGGACTCAGCC
TTCCGCGGCATCTGCATGATGATCGGTGTCAACCCGGGGGGCGTTGTGCAGGACTTTATT
TTCTTCTGCGATGCTGTAGCCTCCTGGGTGAGCCCGAAGGATGACCTTCGGGACATGTTT
TATAAGATTCTCCACGGCTTCAAAGACCAAGTTGGGGAAGATAACTGGCAGCAGTTCTCT
GAGCAATTCCCGCCGCTGCTCAAGGAGAGGCTGGCGGCTTTCTATGGGGTCTAG
Protein Properties
Number of Residues 897
Molecular Weight 101387.1
Theoretical pI 4.63
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Transportin-2
MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE
PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE
LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF
FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML
LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP
ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED
DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA
IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT
ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD
AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP
YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV
ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS
VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTSPSAIPAI
TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFI
FFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV
GenBank ID Protein 209969838
UniProtKB/Swiss-Prot ID O14787
UniProtKB/Swiss-Prot Entry Name TNPO2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001136196.1
GeneCard ID TNPO2
GenAtlas ID TNPO2
HGNC ID HGNC:19998
References
General References
  1. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  2. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [PubMed:15057824 ]
  3. Siomi MC, Eder PS, Kataoka N, Wan L, Liu Q, Dreyfuss G: Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol. 1997 Sep 22;138(6):1181-92. [PubMed:9298975 ]