Showing Protein Mitochondrial enolase superfamily member 1 (HMDBP08715)

• 14437

1. Antisense RNA to thymidylate synthase
2. rTS

1. Mitochondrion (Probable)

>1332 bp
ATGGTGCGCGGCAGGATCTCCCGGCTCTCGGTCCGGGACGTGCGCTTCCCCACGTCGCTT
GGGGGCCACGGCGCGGACGCCATGCACACGGACCCTGACTACTCGGCTGCCTATGTCGTC
ATAGAAACTGATGCAGAAGATGGAATCAAGGGGTGTGGAATTACCTTCACTCTGGGAAAA
GGCACTGAAGTTGTTGTCTGTGCTGTGAATGCCCTCGCCCACCATGTGCTCAACAAGGAC
CTCAAGGACATTGTTGGTGACTTCAGAGGCTTCTATAGGCAGCTCACAAGTGATGGGCAG
CTCAGATGGATTGGTCCAGAAAAGGGCGTGGTGCACCTGGCGACAGCGGCCGTCCTAAAC
GCGGTGTGGGACTTGTGGGCCAAGCAGGAGGGAAAGCCTGTCTGGAAGTTACTTGTGGAC
ATGGATCCCAGGATGCTGGTATCCTGCATAGATTTCAGGTACATCACTGATGTCCTGACT
GAGGAGGATGCCCTAGAAATACTGCAGAAAGGTCAAATTGGTAAAAAAGAAAGAGAGAAG
CAAATGCTGGCACAAGGATACCCTGCTTACACGACATCGTGCGCCTGGCTGGGGTACTCA
GATGACACGTTGAAGCAGCTCTGTGCCCAGGCGCTGAAGGATGGCTGGACCAGGTTTAAA
GTAAAGGTGGGTGCTGATCTCCAGGATGACATGCGAAGATGCCAAATCATCCGAGACATG
ATTGGACCGGAAAAGACTTTGATGATGGATGCCAACCAGCGCTGGGATGTGCCTGAGGCG
GTGGAGTGGATGTCCAAGCTGGCCAAGTTCAAGCCATTGTGGATTGAGGAGCCAACCTCC
CCTGATGACATTCTGGGGCACGCCACCATTTCCAAGGCACTGGTCCCATTAGGAATTGGC
ATTGCCACAGGAGAACAGTGCCACAATAGAGTGATATTTAAGCAACTCCTACAGGCGAAG
GCCCTGCAGTTCCTCCAGATTGACAGTTGCAGACTGGGCAGTGTCAATGAGAACCTCTCA
GTATTGCTGATGGCCAAAAAGTTTGAAATTCCTGTTTGCCCCCATGCTGGTGGAGTTGGC
CTCTGTGAACTGGTGCAGCACCTGATTATATTTGACTACATATCAGTTTCTGCAAGCCTT
GAAAATAGGGTGTGTGAGTATGTTGACCACCTGCATGAGCATTTCAAGTATCCCGTGATG
ATCCAGCGGGCTTCCTACATGCCTCCCAAGGATCCCGGCTACTCAACAGAAATGAAGGAG
GAATCTGTAAAGAAACACCAGTATCCAGATGGTGAAGTTTGGAAGAAACTCCTTCCTGCT
CAAGAAAATTAA

• MR_MLE (PF01188 )
• MR_MLE_N (PF02746 )

• None

• None

>Mitochondrial enolase superfamily member 1
MVRGRISRLSVRDVRFPTSLGGHGADAMHTDPDYSAAYVVIETDAEDGIKGCGITFTLGK
GTEVVVCAVNALAHHVLNKDLKDIVGDFRGFYRQLTSDGQLRWIGPEKGVVHLATAAVLN
AVWDLWAKQEGKPVWKLLVDMDPRMLVSCIDFRYITDVLTEEDALEILQKGQIGKKEREK
QMLAQGYPAYTTSCAWLGYSDDTLKQLCAQALKDGWTRFKVKVGADLQDDMRRCQIIRDM
IGPEKTLMMDANQRWDVPEAVEWMSKLAKFKPLWIEEPTSPDDILGHATISKALVPLGIG
IATGEQCHNRVIFKQLLQAKALQFLQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVG
LCELVQHLIIFDYISVSASLENRVCEYVDHLHEHFKYPVMIQRASYMPPKDPGYSTEMKE
ESVKKHQYPDGEVWKKLLPAQEN

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3. Dolnick BJ: Cloning and characterization of a naturally occurring antisense RNA to human thymidylate synthase mRNA. Nucleic Acids Res. 1993 Apr 25;21(8):1747-52. [PubMed:8493092 ]
4. Dolnick BJ, Black AR: Alternate splicing of the rTS gene product and its overexpression in a 5-fluorouracil-resistant cell line. Cancer Res. 1996 Jul 15;56(14):3207-10. [PubMed:8764108 ]
5. Dolnick BJ, Black AR, Winkler PM, Schindler K, Hsueh CT: rTS gene expression is associated with altered cell sensitivity to thymidylate synthase inhibitors. Adv Enzyme Regul. 1996;36:165-80. [PubMed:8869746 ]
6. Dolnick BJ, Angelino NJ, Dolnick R, Sufrin JR: A novel function for the rTS gene. Cancer Biol Ther. 2003 Jul-Aug;2(4):364-9. [PubMed:14508106 ]
7. Liang P, Nair JR, Song L, McGuire JJ, Dolnick BJ: Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene. BMC Genomics. 2005 Sep 14;6:125. [PubMed:16162288 ]
8. Dolnick R, Wu Q, Angelino NJ, Stephanie LV, Chow KC, Sufrin JR, Dolnick BJ: Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells. Cancer Res. 2005 Jul 1;65(13):5917-24. [PubMed:15994970 ]