Showing Protein Histone-lysine N-methyltransferase SETD1B (HMDBP09034)

• 14776

1. Lysine N-methyltransferase 2G
2. SET domain-containing protein 1B
3. hSET1B

• Lysine degradation

1. Nucleus speckle
2. Chromosome

>5772 bp
ATGGAGAACAGTCACCCCCCCCACCACCACCACCAGCAGCCCCCGCCGCAGCCCGGCCCT
TCGGGCGAGAGGAGGAACCACCATTGGAGAAGTTACAAGTTGATGATTGACCCGGCTCTG
AAAAAGGGGCATCATAAACTGTACCGCTACGATGGGCAGCATTTCAGCCTGGCGATGTCC
AGCAACCGCCCGGTGGAAATTGTCGAAGATCCCCGGGTCGTCGGGATCTGGACCAAAAAC
AAGGAGCTGGAGCTGTCGGTGCCCAAATTCAAGATCGATGAGTTCTACGTGGGCCCGGTG
CCTCCGAAGCAGGTGACATTTGCCAAGCTGAATGATAACATCCGTGAAAACTTCCTGAGG
GACATGTGCAAGAAGTATGGGGAGGTGGAGGAGGTGGAGATTTTGTACAACCCCAAGACC
AAGAAGCACCTGGGCATCGCCAAGGTGGTCTTTGCCACGGTCCGGGGAGCCAAGGATGCC
GTTCAGCACTTGCACAGCACTTCCGTCATGGGCAACATTATCCACGTGGAGCTGGACACC
AAAGGGGAAACCCGAATGCGGTTCTATGAACTGTTGGTCACTGGCCGATACACCCCCCAG
ACCCTCCCAGTGGGCGAGCTGGACGCTGTCTCTCCAATCGTGAATGAGACCCTGCAGCTG
TCAGATGCCCTGAAGCGCCTCAAGGATGGAGGCCTGTCTGCAGGCTGTGGCTCCGGCTCC
TCCTCTGTCACCCCCAATAGCGGTGGGACACCCTTCTCCCAGGACACAGCTTATTCCAGC
TGCCGCCTGGACACACCCAACTCCTATGGACAGGGCACCCCGCTCACACCGCGCCTGGGC
ACCCCTTTCTCACAGGACTCCAGCTACTCCAGCCGCCAGCCCACACCCTCATACCTCTTC
AGCCAGGACCCTGCAGTGACCTTCAAGGCCCGGCGCCACGAGAGCAAGTTCACGGACGCC
TACAACCGCCGCCACGAACATCATTATGTACACAATTCTCCCGCGGTCACTGCGGTGGCC
GGGGCCACAGCCGCTTTCCGGGGTTCCTCGGACCTCCCGTTCGGAGCAGTCGGCGGCACT
GGGGGCAGCAGCGGTCCCCCGTTCAAGGCTCAACCACAGGATTCAGCCACATTTGCCCAC
ACTCCACCACCCGCCCAAGCAACCCCTGCTCCTGGATTCAAGTCTGCTTTCTCTCCGTAT
CAGACCCCAGTGGCCCACTTCCCTCCACCCCCGGAAGAGCCCACCGCCACAGCCGCTTTT
GGGGCCCGCGACAGTGGGGAGTTCCGGAGGGCACCGGCGCCCCCACCCCTGCCACCTGCT
GAGCCTCTGGCCAAGGAGAAGCCAGGCACGCCACCCGGCCCGCCGCCCCCCGACACCAAC
AGCATGGAGCTGGGCGGCCGGCCCACCTTCGGCTGGAGTCCTGAGCCCTGTGACAGCCCT
GGCACGCCCACGCTGGAGTCGTCCCCTGCAGGGCCAGAGAAACCCCACGACAGCCTGGAC
TCGCGCATCGAGATGCTGCTGAAGGAGCAGCGCACCAAGCTGCTCTTCCTGAGGGAGCCG
GACTCGGACACCGAGCTGCAGATGGAGGGCAGCCCCATCTCCTCCTCCTCCTCCCAGCTC
TCCCCACTGGCCCCCTTTGGCACCAACTCCCAGCCAGGCTTCCGGGGCCCCACGCCCCCC
TCGTCACGCCCCTCCAGCACCGGCCTGGAGGATATCAGCCCAACACCCCTCCCAGACTCC
GACGAGGACGAGGAGCTCGACCTGGGCCTTGGGCCTCGGCCTCCACCTGAGCCAGGCCCC
CCGGACCCTGCTGGGCTTCTGAGCCAGACAGCTGAGGTGGCCTTGGACCTGGTTGGAGAC
AGAACCCCGACCTCAGAGAAGATGGATGAGGGCCAGCAGTCCTCAGGCGAGGACATGGAG
ATCTCGGATGACGAGATGCCCTCGGCCCCCATCACCAGCGCTGACTGCCCCAAGCCCATG
GTGGTGACCCCAGGAGCGGCAGCCGTGGCAGCCCCTTCTGTGCTAGCCCCAACCCTGCCG
CTGCCCCCGCCACCTGGCTTCCCCCCGCTGCCCCCCCCACCACCACCACCCCCACCGCAG
CCTGGCTTCCCCATGCCCCCACCGCTGCCCCCACCGCCGCCCCCACCCCCTCCAGCCCAC
CCTGCTGTGACAGTGCCCCCACCACCCTTGCCAGCGCCGCCTGGAGTCCCGCCCCCACCC
ATCCTGCCACCACTGCCCCCCTTTCCGCCGGGCCTGTTCCCTGTGATGCAGGTGGACATG
AGCCACGTGCTGGGTGGCCAGTGGGGCGGCATGCCCATGTCCTTCCAGATGCAAACGCAG
GTGCTCAGCCGGCTGATGACGGGCCAGGGCGCCTGCCCCTACCCGCCCTTCATGGCCGCT
GCGGCCGCCGCTGCCTCAGCTGGGCTCCAGTTTGTCAACCTGCCGCCCTACCGGGGCCCC
TTCTCCCTGAGCAACTCCGGCCCAGGCCGCGGGCAGCACTGGCCACCACTGCCCAAGTTT
GACCCGTCAGTGCCTCCACCAGGCTACATGCCACGCCAGGAGGACCCACACAAAGCCACG
GTGGATGGCGTCCTGCTGGTGGTCCTCAAAGAACTCAAGGCCATCATGAAGCGTGACCTG
AACCGCAAGATGGTGGAAGTGGTGGCTTTCCGGGCCTTTGACGAGTGGTGGGACAAGAAG
GAGCGGATGGCCAAGGCCTCGCTGACCCCGGTGAAGTCGGGCGAGCACAAGGACGAGGAC
AGGCCGAAGCCCAAGGACCGCATCGCCTCGTGCCTGCTGGAGTCATGGGGCAAGGGCGAG
GGCCTGGGCTACGAGGGCCTGGGCCTGGGCATTGGGCTGCGTGGGGCCATTCGCCTGCCC
TCCTTCAAGGTCAAGAGGAAGGAGCCACCAGACACCACCTCATCTGGCGACCAGAAGCGG
CTGCGGCCCTCGACCTCTGTGGATGAGGAAGATGAAGAGTCCGAGCGAGAGCGAGACCGG
GATATGGCAGACACCCCCTGTGAGCTCGCCAAGCGGGACCCCAAGGGCGTGGGTGTGCGG
CGGCGGCCGGCGCGGCCTCTGGAGCTGGACAGTGGTGGGGAGGAGGACGAGAAGGAGTCA
TTGTCGGAGGAACAGGAGAGCACCGAGGAGGAAGAGGAGGCGGAGGAGGAGGAGGAGGAG
GAAGATGACGACGATGACGACAGTGATGACCGGGACGAGTCTGAGAACGATGACGAGGAC
ACAGCCCTGTCAGAGGCGAGTGAGAAGGACGAAGGGGACTCGGATGAAGAGGAGACAGTG
AGCATTGTAACCTCCAAGGCCGAAGCCACGTCGTCCAGTGAGAGTTCCGAGTCTTCTGAG
TTTGAGTCAAGCTCCGAGTCCTCGCCCTCATCCTCGGAGGATGAGGAGGAGGTAGTGGCC
AGGGAAGAGGAGGAAGAAGAGGAGGAGGAGGAGATGGTGGCCGAGGAAAGCATGGCTTCT
GCAGGCCCTGAGGACTTTGAGCAGGACGGGGAGGAAGCGGCTCTGGCCCCGGGGGCACCT
GCAGTGGACTCGTTGGGCATGGAAGAGGAGGTGGACATCGAGACTGAGGCTGTGGCCCCT
GAGGAGCGGCCCTCCATGCTGGACGAGCCCCCCTTGCCTGTGGGTGTTGAAGAGCCAGCG
GACTCCAGGGAGCCGCCTGAGGAACCAGGCCTGAGCCAGGAAGGGGCCATGTTGCTGTCT
CCAGAGCCCCCTGCCAAGGAGGTGGAGGCTCGACCCCCATTGTCCCCTGAGCGAGCTCCA
GAACATGACCTGGAAGTGGAGCCGGAGCCCCCTATGATGCTCCCCTTGCCGCTGCAACCA
CCATTGCCGCCCCCACGACCACCCCGGCCACCCAGCCCACCGCCGGAGCCTGAGACCACA
GATGCCTCACACCCATCTGTCCCTCCGGAGCCCCTTGCCGAGGACCACCCCCCGCATACT
CCAGGCCTCTGTGGCAGCCTGGCCAAGTCGCAGAGCACAGAGACGGTGCCAGCCACACCA
GGCGGGGAGCCCCCGCTATCAGGGGGCAGCAGTGGCCTGTCCCTGAGCTCTCCGCAAGTG
CCCGGCAGCCCCTTCTCCTACCCAGCCCCGTCCCCTAGCTTGAGCAGTGGGGGCCTCCCT
CGGACACCTGGCCGGGACTTCAGCTTCACACCCACCTTCTCCGAGCCCAGCGGGCCCTTG
CTCCTGCCCGTCTGCCCACTCCCCACTGGCCGACGCGATGAACGCTCCGGGCCCCTGGCC
TCCCCGGTGCTCCTGGAGACGGGCCTGCCCCTCCCTCTGCCCCTTCCCCTGCCCTTGCCC
TTGGCATTGCCCGCCGTCTTGCGGGCCCAGGCTCGTGCGCCCACCCCGCTGCCACCCCTG
CTGCCCGCCCCCCTGGCCTCTTGCCCTCCCCCAATGAAGAGGAAGCCGGGCCGGCCCCGG
CGATCCCCACCATCTATGCTCTCCTTGGATGGGCCCTTGGTCCGACCACCAGCAGGGGCC
GCCCTTGGAAGGGAACTCCTGCTCCTGCCGGGCCAGCCACAGACCCCCGTCTTCCCCAGC
ACCCATGACCCCCGGACGGTGACCCTGGACTTCCGGAACGCGGGGATCCCAGCCCCTCCA
CCACCCCTTCCCCCCCAGCCACCCCCACCCCCACCTCCCCCACCTGTAGAGCCCACCAAG
CTGCCCTTTAAGGAGCTAGACAACCAGTGGCCCTCCGAGGCCATTCCTCCGGGCCCCCGT
GGGCGCGATGAGGTCACTGAGGAATACATGGAGTTGGCCAAGAGCCGGGGGCCGTGGCGC
CGGCCACCTAAGAAGCGCCATGAGGACCTGGTGCCACCTGCGGGCTCGCCCGAACTCTCG
CCACCCCAGCCCCTCTTCCGGCCCCGCTCGGAGTTTGAGGAGATGACCATCCTGTATGAC
ATCTGGAACGGTGGCATCGATGAGGAGGACATCCGCTTCCTGTGTGTCACCTACGAGCGA
CTGCTACAGCAGGACAATGGCATGGACTGGCTTAACGACACGCTCTGGGTCTACCATCCC
TCCACCAGCCTCTCTTCAGCTAAGAAGAAGAAACGGGACGATGGCATCCGCGAGCACGTG
ACGGGCTGTGCCCGCAGTGAGGGCTTCTACACCATCGACAAGAAGGACAAGCTCAGATAC
CTCAACAGCAGCCGTGCCAGCACCGATGAGCCCCCCGCAGACACCCAGGGCATGAGCATC
CCAGCACAGCCCCACGCCTCCACCCGGGCAGGCTCGGAGCGGCGTTCGGAGCAGCGCCGC
CTGCTGTCCTCCTTCACTGGCAGCTGTGACAGTGACCTGCTCAAGTTCAACCAGCTCAAG
TTCCGGAAGAAAAAGCTCAAGTTCTGCAAGAGCCACATTCACGACTGGGGCTTGTTCGCC
ATGGAGCCCATCGCGGCTGACGAGATGGTCATCGAGTACGTGGGCCAGAATATCCGTCAG
GTGATCGCAGACATGCGGGAGAAGCGTTATGAGGACGAGGGCATCGGGAGCAGCTACATG
TTCCGGGTGGACCATGACACCATCATCGACGCCACCAAGTGCGGCAACTTCGCGCGCTTC
ATCAACCACAGCTGCAACCCCAACTGCTATGCCAAGGTGATCACGGTGGAGTCACAGAAG
AAGATAGTCATCTACTCGAAGCAGCACATTAACGTCAATGAGGAGATTACCTATGACTAT
AAGTTCCCCATCGAGGACGTCAAGATCCCCTGCCTCTGTGGCTCCGAGAACTGCCGGGGG
ACCCTCAACTAG

• SET (PF00856 )
• RRM_1 (PF00076 )

>Histone-lysine N-methyltransferase SETD1B
MENSHPPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMS
SNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLR
DMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKDAVQHLHSTSVMGNIIHVELDT
KGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSGS
SSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPLTPRLGTPFSQDSSYSSRQPTPSYLF
SQDPAVTFKARRHESKFTDAYNRRHEHHYVHNSPAVTAVAGATAAFRGSSDLPFGAVGGT
GGSSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAF
GARDSGEFRRAPAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSP
GTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQL
SPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGPRPPPEPGP
PDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPM
VVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAH
PAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQ
VLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLSNSGPGRGQHWPPLPKF
DPSVPPPGYMPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKK
ERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLP
SFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVR
RRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDED
TALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVA
REEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAP
EERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAP
EHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHT
PGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLP
RTPGRDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLP
LALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGA
ALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTK
LPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPWRRPPKKRHEDLVPPAGSPELS
PPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHP
STSLSSAKKKKRDDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPADTQGMSI
PAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFA
MEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARF
INHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRG
TLN

• 3UVO
• 4ES0

1. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
2. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
3. Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA: The finished DNA sequence of human chromosome 12. Nature. 2006 Mar 16;440(7082):346-51. [PubMed:16541075 ]
4. Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Jun 30;6(3):197-205. [PubMed:10470851 ]
5. Lee JH, Tate CM, You JS, Skalnik DG: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. J Biol Chem. 2007 May 4;282(18):13419-28. Epub 2007 Mar 13. [PubMed:17355966 ]