Hmdb loader

Showing Protein Probable methyltransferase TARBP1 (HMDBP09040)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP09040
Secondary Accession Numbers
  • 14782
Name Probable methyltransferase TARBP1
Synonyms
  1. TAR RNA-binding protein 1
  2. TAR RNA-binding protein of 185 kDa
  3. TRP-185
Gene Name TARBP1
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
nucleic acid binding
transferase activity, transferring one-carbon groups
methyltransferase activity
rna binding
rna methyltransferase activity
Process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna metabolic process
rna processing
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:1
Locus 1q42.3
SNPs TARBP1
Gene Sequence 
>4866 bp
ATGGAGTGGGTGCTCGCGGAAGCGCTGCTCTCGCAGAGCCGGGACCCCCGGGCCCTGCTT
GGGGCGCTGTGCCAAGGGGAGGCATCCGCGGAGCGCGTGGAGACGCTGCGCTTCCTTCTG
CAGCGGCTCGAGGACGAGGAGGCGCGCGGCAGCGGGGGCGCAGGCGCGCTCCCGGAGGCG
GCGCGCGAGGTGGCTGCAGGGTACCTCGTGCCACTGCTGCGGAGCCTGCGCGGACGCCCC
GCGGGCGGCCCGGACCCCAGTCTGCAGCCTCGCCACCGCCGGCGCGTGCTGAGGGCGGCG
GGCGCGGCCCTGCGCTCGTGCGTCCGCCTGGCCGGGCGTCCGCAGCTGGCGGCCGCGCTG
GCTGAGGAGGCGCTGCGCGATCTGCTCGCCGGGTGGCGCGCGCCTGGCGCCGAGGCTGCC
GTGGAAGTGCTAGCAGCCGTCGGGCCATGTTTGCGGCCCCGCGAGGACGGGCCGCTACTG
GAGCGCGTGGCGGGGACCGCCGTCGCCCTGGCGCTGGGCGGGGGCGGGGACGGGGATGAG
GCCGGGCCTGCCGAGGACGCGGCGGCGCTGGTGGCCGGGCGACTGCTGCCAGTGCTGGTC
CAATGTGGCGGGGCGGCGCTGCGGGCCGTGTGGGGCGGGCTGGCCGCGCCTGGGGCGTCC
CTGGGGTCCGGCCGCGTAGAGGAGAAGCTGCTGGTCCTGAGCGCCCTGGCCGAGAAGCTG
TTGCCCGAGCCCGGCGGCGACCGCGCCCGCGGCGCGCGCGAGGCGGGCCCGGACGCCCGG
CGCTGCTGGCGCTTCTGGAGGACGGTGCAGGCGGGGCTGGGCCAGGCGGACGCCCTGACG
CGCAAGCGAGCGCGCTACCTGCTGCAGAGGGCGGTGGAGGTGTCGGCGGAGCTGGGGGCC
GACTGCACCTGCGGGCCCCAGGAAGGAAACGGCCCAAGTCTGTTTTGGTGGTCTGAGAGG
AAAAAAGATGAGCTTCTAAAGTTTTGGGAAAATTATATTTTAATTATGGAGACTTTAGAA
GGAAATCAGATACATGTTATAAAGCCAGTTTTACCAAAGCTAAACAATCTGTTTGAATAT
GCGGTGTCAGAGGAAAATGGATGTTGGCTCTTTCACCCATCCTGGCATATGTGTATTTAT
AAAAGAATGTTTGAAAGTGAAAACAAAATCCTGTCCAAAGAAGGTGTTATCCATTTTTTG
GAGCTGTATGAAACAAAGATTCTTCCATTTTCACCAGAATTTTCTGAGTTTATTATTGGA
CCATTAATGGATGCGCTTTCAGAGAGCTCTCTGTATAGCAGGTCCCCAGGCCAGCCAATA
GGAAGCTGTTCTCCATTGGGACTGAAATTACAGAAGTTTTTAGTCACTTATATTTCTCTT
CTTCCAGAAGAAATAAAGAGTAGCTTCCTATTGAAGTTTATTCGGAAGATGACAAGTAGG
CATTGGTGTGCTGTTCCCATTTTGTTTCTATCTAAGGCTTTGGCAAATGTCCCAAGACAT
AAGGCCCTGGGTATAGATGGGCTTCTTGCTCTCAGGGATGTTATTCATTGCACTATGATC
ACACATCAGATTCTCCTGAGAGGGGCAGCCCAATGCTACCTTCTTCAAACAGCTATGAAT
TTGCTAGATGTGGAGAAAGTGTCACTTTCTGATGTCTCAACTTTTCTCATGTCTCTGAGA
CAAGAGGAATCCTTAGGACGAGGAACTTCATTGTGGACAGAGCTGTGTGACTGGCTACGT
GTTAATGAAAGCTATTTTAAGCCATCCCCTACGTGTAGCTCCATTGGACTTCACAAGACA
TCTTTAAATGCTTATGTAAAGAGCATTGTTCAAGAGTATGTTAAGTCATCTGCTTGGGAA
ACAGGAGAAAACTGCTTTATGCCTGATTGGTTTGAAGCCAAGCTTGTTTCTCTGATGGTC
TTGCTGGCTGTGGATGTGGAAGGAATGAAGACTCAGTATAGCGGAAAGCAGAGAACAGAG
AATGTATTGCGGATATTCTTAGACCCTCTTCTGGATGTGCTTATGAAGTTTAGTACCAAT
GCCTACATGCCCTTGCTGAAGACTGACAGATGCCTCCAGCTGCTGTTGAAGCTGTTGAAC
ACATGCAGGTTGAAAGGTTCCAGTGCCCAAGATGATGAGGTGTCTACTGTTCTTCAGAAC
TTTTTCATGTCTACTACAGAGAGCATTTCTGAATTTATTCTCAGAAGACTTACTATGAAT
GAGCTAAATAGTGTTTCAGATCTGGATCGTTGCCATTTATACCTGATGGTGTTAACTGAG
CTTATAAATCTGCATTTGAAGGTTGGGTGGAAAAGGGGTAACCCTATCTGGAGAGTTATT
TCTCTTTTGAAAAATGCATCCATTCAGCATCTTCAAGAGATGGACAGTGGACAGGAGCCA
ACAGTTGGAAGTCAGATTCAGAGAGTAGTGAGCATGGCTGCCTTGGCCATGGTGTGTGAG
GCCATAGACCAGAAGCCTGAGCTGCAGCTGGACTCTCTCCATGCTGGGCCCCTGGAAAGC
TTCCTTTCCTCTCTTCAGCTCAATCAGACGCTGCAGAAGCCCCACGCAGAGGAGCAGAGC
AGTTATGCTCACCCCTTGGAGTGCAGCAGTGTTTTGGAAGAATCGTCATCTTCCCAAGGA
TGGGGAAAAATAGTTGCACAATATATTCATGATCAATGGGTGTGCCTCTCTTTCCTGTTG
AAAAAATATCACACCCTTATACCAACCACAGGGAGTGAAATTCTGGAACCGTTTCTACCT
GCCGTTCAGATGCCAATAAGGACTTTGCAGTCTGCACTAGAAGCCCTCACAGTTCTTTCT
TCTGATCAAGTTTTACCAGTGTTCCATTGCTTGAAAGTGTTGGTTCCCAAGCTTCTGACT
TCCTCTGAATCACTCTGCATAGAGTCTTTTGACATGGCGTGGAAAATTATATCTTCTTTA
AGCAACACTCAGCTGATATTCTGGGCTAATTTAAAAGCTTTTGTTCAGTTTGTTTTTGAT
AACAAAGTTCTTACCATTGCTGCCAAAATCAAGGGCCAGGCATATTTCAAAATAAAAGAG
ATTATGTACAAGATAATTGAAATGTCTGCTATAAAGACTGGAGTCTTCAATACACTGATA
AGTTACTGCTGTCAGTCTTGGATAGTGTCTGCTTCAAATGTGTCCCAAGGATCTTTATCA
AGTGCTAAAAATTATAGCGAACTTATCCTTGAGGCTTGTATATTTGGAACTGTGTTTAGG
CGTGATCAAAGACTTGTTCAGGATGTACAGACCTTCATAGAAAACCTTGGACATGACTGT
GCGGCAAATATTGTTATGGAAAATACTAAGAGAGAAGACCATTATGTGAGAATTTGTGCT
GTCAAATTCCTGTGTTTATTAGATGGCTCCAATATGTCCCACAAGTTGTTTATTGAGGAT
CTTGCAATCAAGCTATTAGATAAAGATGAATTAGTGTCCAAGTCCAAAAAACGCTACTAT
GTGAATTCTCTACAGCACAGAGTGAAAAACCGAGTGTGGCAGACTCTGCTGGTACTTTTC
CCTAGACTTGACCAGAATTTCTTGAATGGAATTATTGACAGGATTTTCCAGGCTGGTTTC
ACCAACAATCAAGCATCCATAAAATATTTTATAGAATGGATTATTATATTGATTCTTCAT
AAATTCCCTCAATTTCTTCCAAAGTTCTGGGATTGTTTTTCTTATGGTGAAGAAAATCTT
AAAACAAGCATTTGTACGTTTTTAGCAGTTTTATCACATTTAGACATTATTACTCAAAAT
ATTCCAGAAAAGAAACTAATTCTGAAGCAAGCCCTTATAGTTGTGCTGCAGTGGTGTTTC
AATCACAATTTTAGTGTTCGACTGTATGCTTTAGTTGCTCTTAAGAAACTCTGGACTGTG
TGTAAAGTGTTAAGTGTTGAAGAATTTGATGCCCTGACTCCTGTGATTGAATCCAGCCTC
CATCAAGTGGAAAGCATGCACGGAGCAGGGAATGCCAAGAAGAATTGGCAACGCATTCAG
GAGCATTTCTTTTTTGCAACATTTCACCCACTCAAGGATTATTGTCTAGAGACCATATTT
TACATCCTTCCACGCCTTTCAGGCCTTATTGAAGATGAATGGATCACCATTGATAAATTT
ACCAGATTCACTGATGTTCCTTTAGCTGCGGGATTTCAGTGGTACCTTTCTCAAACTCAA
CTTAGTAAACTAAAACCAGGTGACTGGTCTCAGCAAGACATAGGTACTAATTTGGTCGAA
GCAGATAACCAAGCGGAGTGGACCGACGTTCAGAAGAAGATTATCCCGTGGAACAGTCGT
GTTTCCGACTTAGACCTGGAGCTCCTGTTTCAGGATCGTGCTGCCAGACTTGGAAAGTCA
ATTAGTAGACTCATCGTTGTGGCCTCGCTCATCGACAAACCGACCAATTTAGGAGGACTG
TGCAGGACCTGTGAGGTATTTGGGGCTTCAGTGCTCGTTGTTGGCAGCCTTCAGTGTATC
AGCGACAAACAGTTTCAGCACCTCAGTGTCTCTGCAGAACAGTGGCTTCCTCTAGTGGAG
GTAAAACCACCTCAGCTAATTGATTATCTGCAGCAGAAGAAAACAGAAGGTTATACCATC
ATTGGAGTGGAACAAACTGCCAAAAGTTTAGACCTAACCCAATATTGCTTTCCTGAGAAA
TCTCTGCTCTTGTTGGGAAATGAACGTGAGGGAATTCCAGCAAATCTGATCCAACAGTTG
GACGTTTGTGTGGAAATTCCTCAACAGGGCATTATCCGCTCCCTGAATGTCCATGTGAGT
GGAGCCCTGCTGATCTGGGAGTACACCAGGCAGCAGCTGCTCTCGCACGGAGATACCAAG
CCATGA
Protein Properties
Number of Residues 1621
Molecular Weight 181672.8
Theoretical pI 7.05
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Probable methyltransferase TARBP1
MEWVLAEALLSQSRDPRALLGALCQGEASAERVETLRFLLQRLEDEEARGSGGAGALPEA
AREVAAGYLVPLLRSLRGRPAGGPDPSLQPRHRRRVLRAAGAALRSCVRLAGRPQLAAAL
AEEALRDLLAGWRAPGAEAAVEVLAAVGPCLRPREDGPLLERVAGTAVALALGGGGDGDE
AGPAEDAAALVAGRLLPVLVQCGGAALRAVWGGLAAPGASLGSGRVEEKLLVLSALAEKL
LPEPGGDRARGAREAGPDARRCWRFWRTVQAGLGQADALTRKRARYLLQRAVEVSAELGA
DCTCGPQEGNGPSLFWWSERKKDELLKFWENYILIMETLEGNQIHVIKPVLPKLNNLFEY
AVSEENGCWLFHPSWHMCIYKRMFESENKILSKEGVIHFLELYETKILPFSPEFSEFIIG
PLMDALSESSLYSRSPGQPIGSCSPLGLKLQKFLVTYISLLPEEIKSSFLLKFIRKMTSR
HWCAVPILFLSKALANVPRHKALGIDGLLALRDVIHCTMITHQILLRGAAQCYLLQTAMN
LLDVEKVSLSDVSTFLMSLRQEESLGRGTSLWTELCDWLRVNESYFKPSPTCSSIGLHKT
SLNAYVKSIVQEYVKSSAWETGENCFMPDWFEAKLVSLMVLLAVDVEGMKTQYSGKQRTE
NVLRIFLDPLLDVLMKFSTNAYMPLLKTDRCLQLLLKLLNTCRLKGSSAQDDEVSTVLQN
FFMSTTESISEFILRRLTMNELNSVSDLDRCHLYLMVLTELINLHLKVGWKRGNPIWRVI
SLLKNASIQHLQEMDSGQEPTVGSQIQRVVSMAALAMVCEAIDQKPELQLDSLHAGPLES
FLSSLQLNQTLQKPHAEEQSSYAHPLECSSVLEESSSSQGWGKIVAQYIHDQWVCLSFLL
KKYHTLIPTTGSEILEPFLPAVQMPIRTLQSALEALTVLSSDQVLPVFHCLKVLVPKLLT
SSESLCIESFDMAWKIISSLSNTQLIFWANLKAFVQFVFDNKVLTIAAKIKGQAYFKIKE
IMYKIIEMSAIKTGVFNTLISYCCQSWIVSASNVSQGSLSSAKNYSELILEACIFGTVFR
RDQRLVQDVQTFIENLGHDCAANIVMENTKREDHYVRICAVKFLCLLDGSNMSHKLFIED
LAIKLLDKDELVSKSKKRYYVNSLQHRVKNRVWQTLLVLFPRLDQNFLNGIIDRIFQAGF
TNNQASIKYFIEWIIILILHKFPQFLPKFWDCFSYGEENLKTSICTFLAVLSHLDIITQN
IPEKKLILKQALIVVLQWCFNHNFSVRLYALVALKKLWTVCKVLSVEEFDALTPVIESSL
HQVESMHGAGNAKKNWQRIQEHFFFATFHPLKDYCLETIFYILPRLSGLIEDEWITIDKF
TRFTDVPLAAGFQWYLSQTQLSKLKPGDWSQQDIGTNLVEADNQAEWTDVQKKIIPWNSR
VSDLDLELLFQDRAARLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCI
SDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGVEQTAKSLDLTQYCFPEK
SLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQLLSHGDTK
P
GenBank ID Protein 56204383
UniProtKB/Swiss-Prot ID Q13395
UniProtKB/Swiss-Prot Entry Name TARB1_HUMAN
PDB IDs Not Available
GenBank Gene ID AL136124
GeneCard ID TARBP1
GenAtlas ID TARBP1
HGNC ID HGNC:11568
References
General References
  1. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [PubMed:16710414 ]
  2. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  3. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  4. Wu-Baer F, Lane WS, Gaynor RB: The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. EMBO J. 1995 Dec 1;14(23):5995-6009. [PubMed:8846792 ]
  5. Wu-Baer F, Sigman D, Gaynor RB: Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7153-7. [PubMed:7638159 ]
  6. Wu-Baer F, Lane WS, Gaynor RB: Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. J Biol Chem. 1996 Feb 23;271(8):4201-8. [PubMed:8626763 ]