| Identification |
|---|
| HMDB Protein ID
| HMDBP13913 |
| Secondary Accession Numbers
| None |
| Name
| Glucose-dependent insulinotropic receptor |
| Synonyms
|
- G-protein coupled receptor 119
|
| Gene Name
| GPR119 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. |
| Pathways
|
- cAMP signaling pathway
- Insulin secretion
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| insulin secretion |
| regulation of metabolic process |
| Cellular Component |
| integral to membrane |
| cytoplasm |
| plasma membrane |
| receptor complex |
| Molecular Function |
| phosphatidylcholine binding |
| G protein-coupled receptor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 468 |
| Molecular Weight
| 51685.525 |
| Theoretical pI
| 6.832 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 7-27;38-58;82-102;126-146;165-185;227-247;263-283;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q7TQN8 |
| UniProtKB/Swiss-Prot Entry Name
| GP119_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB: Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 2003 Nov 20;554(3):381-8. [PubMed:14623098 ]
- Soga T, Ohishi T, Matsui T, Saito T, Matsumoto M, Takasaki J, Matsumoto S, Kamohara M, Hiyama H, Yoshida S, Momose K, Ueda Y, Matsushime H, Kobori M, Furuichi K: Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51. doi: 10.1016/j.bbrc.2004.11.120. [PubMed:15607732 ]
- Chu ZL, Jones RM, He H, Carroll C, Gutierrez V, Lucman A, Moloney M, Gao H, Mondala H, Bagnol D, Unett D, Liang Y, Demarest K, Semple G, Behan DP, Leonard J: A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9. doi: 10.1210/en.2006-1608. Epub 2007 Feb 8. [PubMed:17289847 ]
|
